for the treatment of these associated pathologies (Figure 2.8). Therefore, it has been established that a major cause of cancer is metabolic imbalance conditions including hypercholesterolemia, diabetes, hypertension, specific drug use. Effective interventions to reduce their prevalence could potentially reduce cancer risk
2.6 Conclusion
The book chapter covered the evidence that changes in the urban lifestyle is one of the major causes leading to obesity and associated chronic diseases including cardiometabolic syndrome, metabolic dysregulations, and also cancer. It is important to formulate strategies on public health based on bearable lifestyle changes and sustainable urbanisation to curb obesity in the population and risk of cardiometabolic syndrome and associated cancer. Lifestyle interventions, weight management, and low‐calorie food intake are crucial to mitigate increasing global burden of obesity, cardiovascular, and metabolic risk factors. Along with this improvement of medical and research facilities to develop anti‐hypertensive and cardio‐protective compounds is a crucial step towards treatment (Kundu et al. 2021a, 2021b). Individual sensitisation and choices are crucial in the case of nutritional intake and the promotion of healthy lifestyle. Government, private, technical, financial, and institutional capacities have to work together for the implementation of adequate land‐use planning, well‐governed cities, and more sustainable infrastructure and environment with open and recreational spaces to mitigate impacts of climate change and unhealthy lifestyles on health. The World Health Organisation has provided a global strategy and action plan to strengthen initiatives for the prevention and control of noncommunicable diseases. Similarly, to curb these life‐threatening disorders individual alertness and population‐based collective approach is the need of the hour.
Paths for bicycling, walking, etc. are also essential. Instead of junk foods, balanced diets can be promoted for regular intake by the children and individuals with genetic backgrounds of developing metabolic syndromes. More research should be commenced urgently to decipher the underlying molecular mechanisms connecting metabolic syndrome with other environmental and societal factors to generate sustainable strategies to develop a better world for the future.
Acknowledgements
All authors of the book chapter would like to acknowledge the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi, India for various help to complete the current work. Sanjay Kumar Dey acknowledges the University of Delhi, Institute of Eminence grant (IoE/2021/12/FRP).
Authors also acknowledge the use of the academic user license of BioRender (https://biorender.com) for preparing few of the figures shown in the current book chapter.
References
1 Altizer, S., Ostfeld, R.S., Johnson, P.T. et al. (2013). Climate change and infectious diseases: from evidence to a predictive framework. Science 341 (6145): 514–519. https://doi.org/10.1126/science.1239401.
2 Arora, N., Gavya, S.L., and Ghosh, S.S. (2018). Multi‐facet implications of PEGylated lysozyme stabilized‐silver nanoclusters loaded recombinant PTEN cargo in cancer theranostics. Biotechnology and Bioengineering 115 (5): 1116–1127. https://doi.org/10.1002/bit.26553.
3 Bahadoran, Z., Mirmiran, P., and Azizi, F. (2016). Fast food pattern and cardiometabolic disorders: a review of current studies. Health Promotion Perspectives 5 (4): 231–240. https://doi.org/10.15171/hpp.2015.028.
4 Bai, X., McPhearson, T., Cleugh, H. et al. (2017). Linking urbanization and the environment: conceptual and empirical advances. Annual Review of Environment and Resources 42 (1): 215–240. https://doi.org/10.1146/annurev‐environ‐102016‐061128.
5 Berger, N.A. (2014). Obesity and cancer pathogenesis. Annals of the New York Academy of Sciences 1311: 57–76. https://doi.org/10.1111/nyas.12416.
6 Bielecka‐Dabrowa, A., Wierzbicka, M., and Goch, J.H. (2007). Proinflammatory cytokines in cardiovascular diseases as potential therapeutic target. Wiadomości Lekarskie 60 (9–10): 433–438. https://europepmc.org/article/med/18350717.
7 Bishayee, A. (2014). The role of inflammation and liver cancer. Advances in Experimental Biology and Medicine 816: 401–435. https://doi.org/10.1007/978‐3‐0348‐0837‐8_16.
8 Bouzid, M., Colón‐González, F.J., Lung, T. et al. (2014). Climate change and the emergence of vector‐borne diseases in Europe: case study of dengue fever. BioMed Central Public Health 14 (1): 781. https://doi.org/10.1186/1471‐2458‐14‐781.
9 Brunzell, J.D., Davidson, M., Furberg, C.D. et al. (2008). Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. Journal of the American College of Cardiology 51 (15): 1512–1524. https://doi.org/10.2337/dc08‐9018.
10 Castro, J.P., El‐Atat, F.A., McFarlane, S.I. et al. (2003). Cardiometabolic syndrome: pathophysiology and treatment. Current Hypertension Reports 5 (5): 393–401. https://doi.org/10.1007/s11906‐003‐0085‐y.
11 Chella Krishnan, K., Mehrabian, M., and Lusis, A.J. (2018). Sex differences in metabolism and cardiometabolic disorders. Current Opinion in Lipidology 29 (5): 404–410. https://doi.org/10.1097/mol.0000000000000536.
12 Congdon, P. (2019). Obesity and urban environments. International Journal of Environmental Research and Public Health 16 (3): 464. https://doi.org/10.3390/ijerph16030464.
13 Corvalán, C., Uauy, R., Kain, J., and Martorell, R. (2010). Obesity indicators and cardiometabolic status in 4‐y‐old children. American Journal of Clinical Nutrition 91 (1): 166–174. https://doi.org/10.3945/ajcn.2009.27547.
14 Costello, A., Abbas, M., Allen, A. et al. (2009). Managing the health effects of climate change: lancet and University College London Institute for Global Health Commission. The Lancet 373 (9676): 1693–1733. https://doi.org/10.1016/s0140‐6736(09)60935‐1.
15 Dara Hope, C. and Derek, L. (2012). Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocrine‐Related Cancer 19 (5): F27–F45. https://doi.org/10.1530/ERC‐11‐0374.
16 De Blois, J., Kjellstrom, T., Agewall, S. et al. (2015). The effects of climate change on cardiac health. Cardiology 131 (4): 209–217. https://doi.org/10.1159/000398787.
17 DeMarco, V.G., Johnson, M.S., Whaley‐Connell, A.T., and Sowers, J.R. (2010). Cytokine abnormalities
