href="#ulink_91ba82b4-fcd5-5805-bccd-a9cbe3a719bb">Cannabis Tincture (Glycerin)
For those who prefer not to use alcohol, food-grade glycerin is an alternative solvent. Using ½ gallon (64 fluid ounces) of food-grade glycerin will be sufficient to process three ounces (84 grams) of quality cannabis buds. Again, the more cannabis you add, the more potent and stronger it will be. Unlike the “cold tincture” method with the alcohol tincture, a glycerin tincture requires some heat to assist the absorption of the cannabinoids. The plant material should be finely ground and placed into a crock pot (slow cooker) on the lowest setting, and left to heat for at least 12 hours with the lid on. Ensure the setting is low enough not to burn the mixture. After the heating process allow the mixture to cool and strain as before.
The most common form of suppository is the rectal suppository, a very effective method of administration for the delivery of cannabinoids. Suppositories are designed to dissolve or melt and this allows the active ingredients (in this case cannabinoids) to enter the bloodstream via the blood vessels lining the rectum. There are many advantages to this method of administration:
Suppositories are very easy to make. Add half a gram of oil to three grams of natural cocoa butter, slowly melt, and mix thoroughly. Professional suppository molds are available online, or alternatively you can create a simple mold by wrapping tin foil round your little finger. If you have made capsules for oral application, these can also be used as a suppository. However, some people may find that they need to apply a small amount of lubricant to aid insertion.
Studies indicate that using THC-HS suppositories for rectal administration offers around twice the bioavailability of oral administration.23 Converting THC into the ester THC-HS makes it water soluble, improving uptake and bioavailability. However, the esterfication of cannabinoids is beyond the scope of this book.
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