as demonstrated in PCa cells; b) high levels of both cholesterol and B-Sit can cause lipid peroxidation. For these reasons, B-Sit should always be administered in a composition that includes complementary antioxidants, in order to counter the ROS activity and support its action in the cell membrane and intracellular environment. Regarding the effects on cancer, the practical effects of inadequate or incompatible antioxidants with B-Sit would be a leveling off at a balance between increased apoptosis and increased proliferation.
The B-Sit/AOX Matrix
The B-Sit/AOX Matrix interaction is complex, requiring multi-supplement support. In some ways the relationship is as symbiotic as it is synergistic. For example: B-Sit potentiates antioxidant activity and activates other antioxidant responses. B-Sit and plant-based antioxidants work together to protect cell membranes from lipid peroxidation.19-21 In addition, targeted antioxidants support activities of B-Sit: i.e. Astragalus root and B-Sit work together to increase the activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)21,22
A natural pairing of B-Sit and select antioxidants, forming a supportive nutritional matrix, is fundamental to a wide range of biological processes, so the components of the matrix need to be selected to fit the desired outcome. In this case, the Matrix is comprised of B-Sit and antioxidants that work with it to improve membrane integrity and function, reestablish a healthy intracellular fluid environment, as well as support healthy cell reproduction and the body’s mechanisms for controlling improperly reproduced cells – cancer cells.
A select group of antioxidants that form the B-Sit/AOX Matrix for natural anti-cancer support are: Astragalus, ellagic acid, Gynostemma pentaphyllum, Ligustrum fruit, lutein, lycopene, quercetin, resveratrol, Rhodiola, Rosmarinus officinalis, Schinsandra fruit, trans-e-viniferin, Wasabia japonica, and zinc.
Synergy within the Matrix
Just like the components that make up foods, to be efficient the Matrix needs to be comprised of nutrients that work together, for example:
•Quercetin and resveratrol work together to naturally reduce inducible nitric oxide synthase (iNOS) gene expression and nitric oxide production, providing cardiovascular support and other benefits.23
•Resveratrol and ellagic acid aid the cell’s structural ability to repair efficiently.24
•Ellagic acid and quercetin synergistically support normal reproduction rates and proper apoptosis when balanced at dietary-level concentrations.25,26
•B-Sit and resveratrol combine to provide a balanced ROS1 level, and synergistically inhibit inappropriate cell growth. In addition, the systemic presence of B-Sit enhances resveratrol activity.27
Curcumin and B-Sit/AOX Matrix Synergy
There is growing investigation into the use of curcumin for the treatment of cancer. One of the drawbacks is the diminished effect of curcumin with increased levels of insulin. At the same time, an increased level of insulin and insulin resistance are known risk factors for developing prostate and breast cancer, as well as other cancers, and is often a cofactor with cancer patients. B-Sit reduces insulin resistance (most likely by restoring membrane function, especially selective permeability) and regulates insulin production through several mechanisms, one of which is by supporting normal cholesterol homeostasis. In addition, curcumin inhibits cell membrane cholesterol accumulation, furthering the effects of B-Sit, via a different mechanism.
An ideal curcumin will be naturally absorbed, maintain effective serum levels for at least 12-hours in order to allow for 24-hour effective blood levels without frequent dosing, and store in the liver for release throughout the day. In this way, doses of as little as 1,000 mg to 4,000 mg are recommended.
Coenzyme Q10 and the B-Sit/AOX Matrix
There are a number of key reasons why CoQ10 should always be included in the Matrix. Firstly, it is essential for proper cell reproduction. Secondly, it has been shown that when the circumstances for metastases are set up, the process is not triggered if there is adequate CoQ10 present. CoQ10 has been demonstrated to reduce IL-8 to normal levels. As noted above, IL-8 is the primary inflationary mechanism that drives the formation and survival of tumor cells for all cancers. Reducing IL-8 also works with the other components of the Matrix to reduce angiogenesis. The efficiency of CoQ10’s function in the cell membrane and for overall cell function is restored in cancer cells through the reestablishment of membrane elasticity and permeability by B-Sit.
An ideal CoQ10 is highly absorbable – 100% of what is supplemented needs to be available for absorption. The circulating CoQ10 needs to be readily able to cycle from the ubiquinone to ubiquinol, and be orthomolecular in nature, thus allowing it to be cellularly-bioavailable. Preferably, the CoQ10 used should have a long clinical track record and have demonstrated research efficacy. The recommended dose range is 300 to 800 mg/day.
Using B-Sit/AOX Matrix Nutrition
The above forms the basis for the nutritional support we use. As appropriate for each individual, a more complete program is developed including: vitamin D3 to bring the D3 levels to 65 - 90 ng/ml; mixed tocopherols with high gamma-tocopherol (taken in the morning) and 125 to 500 mgs of a high-delta-tocotrienol supplement taken in the evening; a balanced calcium and magnesium supplement; vitamin K2; vitamin B Complex; and 5 grams of vitamin C.
Given that the basis of the Matrix is to restore essential missing nutrients, it can be used in a general nutrition program, during treatment, and for anyone who has developed cancer as life-long maintenance nutrition.
CONCLUDING REMARKS
Monitoring and Follow-Up
The nutritional program outlined above, the B-Sit/AOX Matrix, has been used for over 5-years, and the results reported in the first section are based on this use. Visually, this can be seen in Figure 1, which shows imaging results of the same prostate, initially diagnosed as a Gleason 7 (image a) and upon a follow-up examine after daily use of the above supplement regime (image b).
The results shown in Figure 1 illustrate both the efficacy of restoring fundamental nutritional support that has been systematically removed from our diets by alterations in the food supply, and the need for a means to monitor, on a regular basis, each individual’s response to treatment. Given the number of factors involved in nutritional support, this is the only way to know that this individual’s body is capable of restoring its anti-cancer functions. The same monitoring approach can be applied to any therapeutic intervention, especially since the 3-D sonogram is not compromised by the treatment itself.
Figure 1. Prostate cancer subject treated with B-Sit/AOX supplement program. a) DCE-MRI of Gleason 7 non-palpable prostate cancer (yellow arrow), (vascular enhancement is red), b) Post treatment scan of same area showing disappearance of vascular enhancement.
When establishing a monitoring schedule for an individual, two additional areas need to be kept in mind, interval cancers and evaluating successful treatment. The concept of fast growing cancers called “interval cancers” has led to routine biannual screening of male and female high risk patients. It is recognized that mammography misses invasive breast cancers with great frequency, so there is a half-year time
