17Table 17.1 Selected hereditary human endocrine cancer syndromes and GEMa ph...16 Chapter 18Table 18.1 Examples of strain‐specific lesions and phenotypes of the renal ...Table 18.2 Common laboratory mouse strains: degree of susceptibility to exp...Table 18.3 Clinical chemistry testing in evaluation of mice for kidney dise...Table 18.4 Selected pathology stains and methods.Table 18.5 Mean glomerular numbers per kidney in adult mice.aTable 18.6 Major causes of nephrotic and nephritic syndromes in humans.aTable 18.7 Nephrotic and other proteinuric glomerular diseases modeled in t...Table 18.9 Examples of mouse models of human glomerular nephritic diseases.Table 18.10 Spontaneous tubular lesions in mice.aTable 18.11 Selected genetic tubular diseases, including cystic diseases, m...Table 18.12 Phenotypes of selected human kidney cancer genes and of genetic...
17 Chapter 19Table 19.1 Common immunohistochemical markers.Table 19.2 Major genetic alterations affecting gonadal structure or functio...Table 19.3 Some major models for studying human female reproductive tract d...
18 Chapter 20Table 20.1 Classification of lesions of the prostate in genetically enginee...Table 20.2 Select GEM models of prostate cancer.Table 20.3 Selected immunohistochemical markers to identify different cell ...Table 20.4 Examples of GEM models of male infertility/subfertility with cor...Table 20.5 Examples of GEM models of male infertility/subfertility with cor...
19 Chapter 21Table 21.1 Functional regions of the central nervous system.Table 21.2 Main cell types of the central nervous system.Table 21.3 Examples of spontaneous strain‐specific lesions in the mouse.Table 21.4 Examples of age‐related lesions in the mouse.Table 21.5 Quick guide to the pros and cons of commonly used AD mouse model...Table 21.6 Commonly used mouse models of amyotrophic lateral sclerosis and ...Table 21.7 Mouse models of spinocerebellar ataxia and cerebellar mutants.Table 21.8 Selected mouse models for study of EAE.Table 21.9 Selected mouse models of lysosomal storage diseases.Table 21.10 Spontaneous and genetically engineered mouse models of epilepsy...
20 Chapter 22Table 22.1 Select list of inbred mouse strains with aPde6brd1 mutation.Table 22.2 Genes and spontaneous mutations of the laboratory mouse eye that...Table 22.3 Selected genetically engineered and mutant mice for glaucoma and...Table 22.4 Select genetically engineered and mutant mice for with hearing a...
List of Illustrations
1 Chapter 1Figure 1.1 Classes of proteins associated with human genetic diseases.
2 Chapter 2Figure 2.1 Data integration strategy for Monarch. Data, mainly “genotype‐to‐...Figure 2.2 The Mouse Models of Human Cancer Database (MMHC), formerly Mouse ...Figure 2.3 IMPC phenotyping pipelines for adult mice (17 weeks) and embryos...Figure 2.4 The histopathology browser for the IMPC database. Data can be sea...
3 Chapter 3Figure 3.1 Top, searching p53 SNPs reveals “The gene you selected is not in ...Figure 3.2 Finding the gene and allele symbol on Mouse Genome Informatics. O...Figure 3.3 Current symbols assigned to a variety of unrelated genes original...Figure 3.4 Nomenclature for hybrid stocks.Figure 3.5 Setting up a mapping cross using F1 and F2 hybrids.Figure 3.6 Crossing AKR/J mice with more than one inbred strain to map the m...Figure 3.7 Using recombinant inbred lines to narrow candidate gene intervals...
4 Chapter 4Figure 4.1 Nonhuman (including mouse) models were historically compared empi...Figure 4.2 Human population response to disease is often highly variable bet...Figure 4.3 Effect of strain on phenotype for a single gene mutation. A class...Figure 4.4 Mouse models identify subtypes of junctional epidermolysis bullos...Figure 4.5 Fitting mouse models to the concepts of human disease. The mouse ...Figure 4.6 Validation of mouse models over time. In 1989 few mouse models ac...
5 Chapter 5Figure 5.1 Composite image of embryonic mouse developmental stages from just...Figure 5.2 Mouse embryo littermates with a shared chronological age at gesta...Figure 5.3 The early placenta (shown here at GD8.5) consists chiefly of mate...Figure 5.4 The definitive placenta forms fully by GD12.5 (Panel (a)), appear...Figure 5.5 The labyrinth of the placenta (shown here for wild‐type CD‐1 mice...Figure 5.6 The nascent metrial gland (also designated the mesometrial lympho...Figure 5.7 Noninvasive imaging modalities are useful means for characterizin...Figure 5.8 Sex differentiation of neonatal (PND1) mice using anogenital dist...Figure 5.9 Schematic diagram showing necropsy approach for neonatal and juve...Figure 5.10 Sectioning (Wilson's) technique to allow macroscopic evaluation ...Figure 5.11 Sectioning (Wilson's) technique to allow macroscopic evaluation ...Figure 5.12 Skeletal double staining may be used to characterize axial patte...Figure 5.13 Developmental anatomy of a wild‐type GD16.0 mouse embryo demonst...Figure 5.14 Missing structures represent a special situation in developmenta...Figure 5.15 Comparison of variable lesion progression in three litters of wi...Figure 5.16 Developmental phenotypes resulting from circulatory disturbances...Figure 5.17 Embryonic death is demonstrated by a spectrum of macroscopic and...Figure 5.18 A common cause of neonatal lethality is inability to suckle, whi...Figure 5.19 An outcome‐oriented decision tree for evaluating embryonic letha...Figure
