Machine Learning Techniques and Analytics for Cloud Security. Группа авторов

      2.1 Introduction

Influenza A is a widespread infectious disease caused by the influenza virus that can easily spread from one person to another by coughing, sneezing, etc. This virus infects hosts like humans, sea-mammals, and swine. The first reported pandemic from 1918 to 1919 and the other two pandemics occurred in the 20th century [1–3]. Every year, 250,000 to 500,000 deaths occurred worldwide for this virus. In the past few years, there are lots of disasters that occurred, for example, pandemic named “Spanish Flu” caused the global death of 60 to 100 million people in the 1918. In 2009, scientists recognized a particular strain of influenza A virus which is known as H1N1 [4, 5]. H1N1 is normally found in swine. For this reason, it is also called “Swine Flu” or “Pig Flu” or “Swine influenza viruses (SIVs)”. It is a human respiratory infection caused by the H1N1 influenza that is basically started in pigs and contains RNA virus with a segmented genome. It is also called orthomyxovirus because it contains haemagglutinin and neuraminidase glycoproteins. Transmission of swine flu to humans is rare. But, swine flu can be transmitted to humans via contact with infected swine or environments contaminated. Once a human gets infected, humans can then spread this virus to other humans, and in the same way, swine flu is spread (i.e., cough or sneezing). It is a mystery that when and where pandemic reassortments will happen. Lots of reports suggest that this type of reassortments is very frequent between human viruses [6]. Influenza has been found very frequently with co-infections and reassortment of swine and human. Cell surface oligosaccharide receptors of the swine windpipe present a NeuAcalpha2, 6 Gal linkages, and preferred by human viruses. Some glycans with sialic acid α2,6-linked (SA2,6Gal) are detected more immense in the upper airways than the lower airways in the human body [7–10]. According to the “central dogma” biological concept, double-stranded DNA is simulated into RNA and this RNA carries some instructions for making proteins that mean DNA to RNA to protein. Glycosylation and phosphorylation are the post-translational modifications techniques that are required to estimate for the accurate regulation that is required by the living system. Every cell is wrapper up with a coat (solid) of glycans to create interface of molecular between the cells and environment of cells. Glycosylation is basically enzymatic techniques where this technique is the key factors to establish the connection of carbohydrates to proteins through nitrogen and oxygen links. Whole process happens with the Endoplasmic Reticulum (cell) that arranged with different types of glycol-sialyltransferases and glycosidases [9–16]. The immune system is an important component to keep up a hygenic and well balanced system that is very organized by a sequence of stimulatory and restrictive ways. If whole system is broken down, then autoimmunity can occur for loss of immune tolerance and it can also effect in unusual costimulatory signals. The proper growth and function of the immune system confide pair on the glycan-structures (expression) and glycan-binding proteins, and the association between them. Innate immune is responsible to identify the molecular “patterns” that basically find on microbes. Microbes are responsible to bind by pattern recognition receptors that is one kind of protein to identify molecules in pathogen, C-type (calcium-dependent), lectins (types are Dectin-1 and DC-SIGN), and mannose-binding lectin. The glycans that are found on sensors of innate immune system can be classified by two effects they are “direct” and “indirect” effects [11–15] and these are playing important role in influencing microbe-host interactions and T and B cell identification. Glycan-binding proteins known as GBP are very important within the immune

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