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4 Genes and Obesity
I. Sadaf Farooqi
Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK
Introduction
Obesity arises from the interaction between genetic, environmental, and behavioral factors acting through the physiologic mediators of energy intake and energy expenditure. Body weight is the archetypal polygenic trait, a quantitative phenotype that usually fails to display a Mendelian pattern of inheritance because it is influenced by many different regions
