Drug Transporters. Группа авторов

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1.0 3.5 mg h/l Imatinib 8–14 l/h 0.72–1.26 l/h 0.05–0.13 400 0.98 36 mg h/l Mesna/dimesna 1.23 l/h/kg 0.41 l/h/kg 0.33 5,000 0.89 3,618 mg h/l/kg Cardiovascular Procainamide 705 391 0.3–0.6 500 1.0 709 μg min/ml Amiodarone 87.5 0 <1% 400 0.5 2.3 mg min/ml Quinidine 2.8 0.7 0.05–0.20 200 0.7 50 mg min/ml Depression Imipramine 1 l/h/kg 0.001 l/h/kg 0.001 100 mg 0.95 95 mg h/l/kg Diabetes Metformin 542–642 542–642 1 850 0.55 779 μg min/ml Hypertension Captopril 0.8 l/h/kg 0.4 l/kg/h 0.95 25 0.75 23.4 mg h/l/kg Diltiazem 11.8 ml/min/kg 4.13 ml/min/kg 0.35 120 0.95 9.7 mg min/ml/kg Verapamil 10.4–12.4 ml/h/kg 7.3–8.7 ml/h/kg 0.70 120 0.20–0.35 2.9 mg h/l/kg Clonidine 180–390 133 0.40–0.60 0.1 0.90 0.3 μg min/ml Atenolol 100–176 95–168 0.40–0.50 50 0.50 17.8 μg min/ml Nadolol 2.78–3.22 ml/min/kg 0.9–1.92 ml/min/kg 0.25 40 0.30 4.0 mg min/ml/kg Leg cramps Quinine 0.17 l/h/kg 0.034 l/h/kg 0.20 650 0.76–0.88 3,058 mg h/l/kg Reflux disease Cimetidine 30–48 l/h 13.8–30 l/h 0.48 400 0.73 7.3 mg h/l

      ^a Units reported other than ml/min are delineated.

      ^b Units reported other than mg are delineated.

TABLE 3.4 MATE1 and MATE2‐K inhibitors identified in human studies

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Indication	Druga	Dose
Asthma	Zafirlukast	20 mg
Cancer	Imatinib	400 mg
Cardiovascular	Ranolazine	1,000 mg
Emesis	Ondansetron	8 mg
Infections	Pyrimethamine	50 mg
	Trimethoprim	200 mg
	Dolutegravir	50 mg
	Isavuconazole	200 mg
	Levofloxacin	750 mg
	Ciprofloxacin	500 mg
	Cetirizine	10 mg
	Cephalexin	500 mg
	Cephradine	500 mg
	Cobicistat	150 mg
	Indinavir	800 mg
	Ritonavir	100 mg
Reflux disease	Cimetidine	400 mg
	Ranitidine	300 mg
	Famotidine	200 mg