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Table of Contents
1 Cover
5 Preface to the fifth edition
7 Part 1: Concepts 1 Microbial pathogens, classification and concepts Characteristics of bacteria Bacterial structural components Bacterial classification Medically important groups of bacteria 2 Innate and acquired immunity Phagocytes Complement and other plasma proteins The adaptive (specific) immune response Damaging immunity 3 The ‘normal’ flora in health and disease Normal flora Physical and chemical barriers 4 Pathogenicity and pathogenesis of infectious disease Definitions Types of pathogen Mechanisms of pathogenicity Damaging the host 5 Making a microbiological diagnosis of infection Specimens Laboratory examination Culture Identification Susceptibility testing Serology Molecular techniques 6 Antimicrobial therapy – principals and concepts Adverse events Acute allergy and intolerance Targeting treatment Monitoring therapy 7 Antibacterial agents – pharmacology and modes of action Beta‐lactam antibiotics Penicillins Cephalosporins Monobactams Carbapenems Aminoglycosides Glycopeptides Daptomycin Quinolones Macrolides Streptogramins Oxazolidinones Metronidazole Tetracyclines Sulphonamides and trimethoprim 8 Antimicrobial use and stewardship A holistic approach in antibiotic therapy Antibiotic prescribing policies Choice of therapy Routes of administration Choosing an antibiotic 9 Emergence and detection of resistance Transmission of resistance determinants between bacteria Mechanisms of resistance 10 Sources and transmission of infection Sources of infection Survival and transmission 11 Principles of infection control Identifying an outbreak Infection control Isolation 12 Infection in the healthcare environment The environment The host Medical activities 13 Immunization
