in weakened, diminished medical effect.
How does your body process marijuana?
The effects of marijuana are produced by a cannabinoid receptor system in your body consisting of at least two receptor types: CB1 and CB2. CB1 receptors are found exclusively in the brain. They are concentrated in the hippocampus and cerebral cortex (see illustration on p. 16), which control memory and cognition. CB1 receptors interact with marijuana’s active compounds to produce its psychoactive effects including the euphoric, blissful state that often makes pain more manageable.
CB2 receptors are termed “peripheral receptors” because they are found outside the brain, primarily in the immune system and organs, especially the spleen and in white blood cells. They may be responsible for the cannabinoids’ other effects, including the reduction of inflammation. Some studies indicate beneficial effects from marijuana on neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.
The cannabinoid receptor system is where marijuana becomes medicine.
The cannabinoid receptor system is where marijuana becomes medicine. These receptors enable humans to obtain the beneficial effects of marijuana’s active ingredients. They regulate numerous biological actions within your body including learning, memory, motor skills, pain relief, body temperature, and heart rate. It is used medically to suppress nausea and alleviate pressure in the eye.
What is an endocannabinoid?
Endocannabinoids are substances produced naturally by your body that activate the CB1 and CB2 receptors to regulate body processes and provide relief from stress and discomfort. The principal endocannabinoid is arachidonylethanolamide, or anandamide (AEA). This naturally occurring lipid is a neurotransmitter found in the brains of all animals on the planet except insects. Researchers are working to find the correlation between AEA and human memory, eating habits, sleep patterns, and pain relief. Studies in rats show that it regulates hunger and food intake.
The endocannabinoid system has multiple functions including regulating immunity, inflammation, neurotoxicity, blood pressure, appetite, gastrointestinal function, glaucoma, epilepsy, depression, and stress. It helps regulate the body’s biological responses to maintain health and activity by restoring balance. There is no human physiological system yet investigated that is not modulated by the endocannabinoid system.
The name anandamide is derived from the Sanskrit word for bliss, ananda.
How will marijuana make you feel?
Usually pretty good. Marijuana creates an intense feeling of well-being. But it doesn’t make everyone feel good all of the time; just most people, most of the time. Your tolerance to it, its potency, and method of intake all affect the intensity that marijuana has on your mind and body.
Inhaling marijuana is the quickest route to the brain. It has a much more rapid onset than when ingesting it in food since it must be digested before its effects are felt. When you inhale, your biological responses change almost instantly. You may find that your throat is dry or that you are thirsty. Your eyes become a little red due to dilation of the blood vessels of the eye. You may look drowsy, an effect called “pseudopodia,” when the musculature of your eyes become relaxed. If you’re a glaucoma patient or suffer from tension afflictions, you may find the pressure reduced in and around your eyes. Your heart may begin to race a little bit, increasing blood flow throughout your body. The upper bronchial passages of your lungs may expand. You’ll most likely feel a relaxing sensation come over you and in a short time you will likely become hungry.
Relaxation, reduced tension, thirst, and hunger are the effects experienced by a majority of people. Some report a comparatively minimal effect during their first few experiences with marijuana, so you may want to try it a couple of times to ensure you are experiencing the total effect. It may take your body chemistry some time to adapt to the biological changes. For this reason, it’s best not to rapidly increase your dosage during your first marijuana experiences. It is better to increase the dosage gradually over several experiences if necessary.
Some people don’t react well to marijuana and report a feeling of anxiety, panic, and dizziness. Anxieties induced by marijuana can create an unpleasant experience. A person under this type of duress will not experience marijuana’s therapeutic value. If you experience a response to marijuana intake that induces anxiety, reducing the dosage for your next exposure might be warranted or perhaps marijuana simply isn’t the right medication for you.
Another consideration is that there are many strains of marijuana. Each has its own chemical composition. One may produce a more desirable effect than another. The method of administration can also make a difference. Marijuana can be administered in a number of ways. These are discussed in detail in Chapter 6. If you experience a negative reaction, don’t panic. Marijuana is safe and nontoxic. Depending on how much marijuana you take in, the symptoms will almost always go away within a few hours.
DON’T BELIEVE THE HYPE.
COMMON MYTHS ABOUT MARIJUANA DEBUNKED
Marijuana has a bad rap. Decades of prohibition have left us uneducated, even scared, of marijuana. Unfortunately, this relatively benign plant is demonized and associated with the lazy, derelict, and criminal fringe of society. Here are some common, though erroneous, claims made about the people who use marijuana:
MARIJUANA MAKES YOU STUPID: This is at the core of the language used to describe a “stoner” or marijuana user. The myth that marijuana kills brain cells or causes brain damage has absolutely no basis in fact. The “stupid” theory also covers the claim that marijuana diminishes your memory.
Most of the misinformation came from one often-cited study performed on monkeys that was later fully disproved by studies on humans in Jamaica and Costa Rica by the U.S. National Center for Toxicological Research and SRI International. Studies on humans found almost no perceivable knowledge deficiency from marijuana use in humans, even after very heavy use.
Like other mind-altering medications, marijuana might temporarily affect your ability to recall facts, verbalize thoughts, concentrate, or learn effectively. These effects normally subside as the medicine wears off, but heavy users may experience more lasting
