target="_blank" rel="nofollow" href="#u22e7ee87-8b1a-586e-b328-7349161625ae">15 Immunopharmacology
Introduction
Drugs that suppress immune responses
Corticosteroids
16 Travel medicine
Introduction
Principles of immunisation
Vaccines used for preventing infection in travellers
Malaria prevention and treatment
Treatment of other common imported parasitic infections
17 Analgesia and anaesthesia
Introduction
Pathophysiology of pain
Management of pain
Opioids
Adjunctive agents
Anaesthesia
Critical care considerations
18 Poisoning and drug overdose
Introduction
General approach to the poisoned patient
The management of specific complications
Features of common drug overdose
Summary
8 Index
List of Tables
1 Chapter 1Table 1.1 P450 inhibitors involved in drug interactions.Table 1.2 Major enzymes displaying genetic polymorphism.Table 1.3 Examples of target ranges.Table 1.4 Factors influencing theophylline clearance and therefore dose requireme...Table 1.5 Predicted steady‐state digoxin concentrations for clinical scenario...Table 1.6 Predicted steady‐state phenytoin concentrations for clinical scenar...Table 1.7 Drugs that can cause liver damage.Table 1.8 Drugs that are known to be teratogenic.Table 1.9 Data from UK epilepsy and pregnancy register 2005.Table 1.10 Influence of anti‐epileptic drug treatment on rates of congenital malf...Table 1.11 Special considerations to be made when prescribing in pregnancy.Table 1.12 Drugs safe for breastfeeding mothers.Table 1.13 Commonly used drugs that should be avoided in women who are breastfeed...
2 Chapter 3Table 3.1 Utility values from selected published studies.Table 3.2 Cost per QALY gained figures from selected published studies (refer...Table 3.3 An example of how QALYs are calculated.
3 Chapter 4Table 4.1 Examples of different types of drug reaction.Table 4.2 Examples of pharmacokinetic interactions.
4 Chapter 5Table 5.1 Drugs that may adversely affect gastrointestinal function.Table 5.2 Common drug‐related gastrointestinal symptoms.
5 Chapter 6Table 6.1 Examples of the pharmacological properties and route of elimination...Table 6.2 Classification of anti‐arrhythmic drug actions.Table 6.3 Aetiology/management of heart failure.Table 6.4 Drugs used to treat heart failure.Table 6.5 Indications and contraindications for the major classes of antihype...Table 6.6 Clinical classification of calcium antagonist drugs.Table 6.7 Drugs acting on the renin–angiotensin system.Table 6.8 Angiotensin II (AT1) receptor antagonists used in hypertension.Table 6.9 Classification and site of action of diuretics.Table 6.10 Summary of the actions of lipid‐lowering drugs.Table 6.11 Clinical conditions in which low‐dose aspirin is of proven benefit...
6 Chapter 7Table 7.1 Inhaled agents used in airways disease.Table 7.2 Main groups of drugs used to treat airflow obstruction.
7 Chapter 8Table 8.1 Therapy for convulsive status epilepticus.Table 8.2 Anti‐epileptic drugs.Table 8.3 Drug‐induced neurological disorders.Table 8.4 Neuroinflammatory disorders.Table 8.5 Symptomatic treatment of chronic neurological disability.Table 8.6 Commonly used antiparkinsonian drug therapy.Table 8.7 Anxiolytic drugs and dose range used.Table 8.8 Benzodiazepine hypnotic drugs.Table 8.9 Drug‐induced psychiatric disorder.
8 Chapter 9Table 9.1 Examples of antimicrobials for which dose modification or caution i...Table 9.2 Examples of antimicrobials for which therapeutic concentrations are...Table 9.3 Major adverse reactions of antimicrobial drugs.Table 9.4 Examples of empirical antibiotic therapy for adults.Table 9.5 Approved antiretroviral drugs in the UK (2019).Table 9.6 Examples of important drug interactions with NNRTIs and PIs.Table 9.7 Combination tablets available in the UK (2019).Table 9.8 Direct acting antivirals by class.Table 9.9 Fixed dose DAA treatments for HCV.
9 Chapter 10Table 10.1 Aspects for consideration in the management of diabetes.Table 10.2 Common drug treatments for type 2 diabetes mellitus.Table 10.3 Insulin formulations.Table 10.4 Adverse effects of insulin therapy.Table 10.5 Pharmacokinetics of GLP‐1 receptor agonists.Table 10.6 Pharmacokinetics of DPP‐4 inhibitors.Table 10.7 Cardiovascular outcomes trials in type 2 diabetes.Table 10.8 Suggested potassium regimen in patients with diabetic ketoacidosis...Table 10.9 Treatments used in the management of thyrotoxicosis.Table 10.10 Vitamin D preparations and their use.Table 10.11 Bisphosphonates.
10 Chapter 11Table 11.1 Situations where combined hormonal contraception is not recommende...
11 Chapter 12Table 12.1 Examples of some targeted therapies and tumour sites where they ar...
12 Chapter 13Table 13.1 Target international normalised ratios (INR) for warfarin anticoag...Table 13.2
