Medical Statistics. David Machin

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Medical Statistics - David  Machin

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4 (4) 9 (4.5) Darnall 5 (5) 1 (1) 6 (3.0) Total 101 (100) 101 (100) 202 (100)

      Labelling Binary Outcomes

Bar chart depicting where 202 patients with corns were treated.

      (Source: Farndon et al. 2013).

Pie chart depicting where 202 patients with foot corns were treated.

      (Source: Farndon et al. 2013).

      If the sample is further classified into whether the patient was treated with corn plasters or scalpel then it becomes impossible to present the data as a single pie or bar chart. We could present the data as two separate pie‐charts or bar charts side by side but it is preferably to present the data in one graph with the same scales and axes to make the visual comparisons easier.

      (Source: Farndon et al. 2013).

      If you do use the relative frequency scale as we have, then it is recommended good practice to report the actual total sample sizes for each group in the legend. In this way, given the total sample size and relative frequency (from the height of the bars) we can work out the actual numbers treated in each centre.

      A quantitative measurement contains more information than a categorical one, and so summarising these data is more complex. One chooses summary statistics to condense a large amount of information into a few intelligible numbers, the sort that could be communicated verbally. The two most important pieces of information about a quantitative measurement are ‘what is the average value?’ and ‘what is the spread of the data?’ These are categorised as measures of location (sometimes ‘central tendency’) and measures of spread or variability. A measure of location (average) and variability (spread) provides an informative but brief summary of a set of observations.

      Measures of Location – The Three ‘Ms’ – Mean, Median and Mode

       Mean or Average

      The arithmetic mean or average of n observations images(pronounced x bar) is simply the sum of the observations divided by their number; thus

equation

      In the above equation, xi represents the individual sample values and images their sum. The Greek letter ‘∑’ (sigma) is the Greek capital ‘S’ and stands for ‘sum’ and simply means ‘add up the n observations xi from the first to the last (nth)’.

       Example – Calculation of the Mean – Corn Size Data (mm)

      In the randomised controlled trial that investigated the effectiveness of salicylic acid plasters compared with usual scalpel debridement for treatment of foot corns (Farndon et al. 2013), the baseline size of the index corn (at its widest diameter in mm) was measured by an independent podiatrist (foot specialist) who was not involved in the subsequent treatment of the patients. Consider the following 16 baseline corn sizes in mm, listed in ascending

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