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ridiculous experiments of the ‘projectors’ – experiments that may have been invented by Swift with the aid of some insider hints from Dr Arbuthnot – inoculation seemed actually to work, most of the time.

      It isn’t experimentation as such that’s the target of Book Three, but experiments that backfire. Moreover, it’s the obsessive nature of the projectors: no matter how many dogs they explode, they keep at it, certain that the next time they inflate a dog they’ll achieve the proposed result. Although they appear to be acting according to the scientific method, they’ve got it backwards. They think that because their reasoning tells them the experiment ought to work, they’re on the right path; thus they ignore observed experience. Although they don’t display the full-blown madness of the truly mad fictional scientists of the mid-twentieth century, they’re a definitive step along the way: the Lagadan Grand Academy was the literary mutation that led to the crazed white-coats of those B movies.

      There were many intermediary forms. Foremost among them was, of course, Mary Shelley’s Dr Frankenstein, he of the man-made monster – a good example of an obsessive scientist blind to all else as he seeks to prove his theories by creating a perfect man out of dead bodies. The first to suffer from his blindness and single-mindedness is his fiancée, murdered by the creature on Dr Frankenstein’s wedding night in revenge for Frankenstein’s refusal to love and acknowledge the living being he himself has created. Next came Hawthorne’s various obsessed experimenters. There’s Dr Rappacini, who feeds poison in small amounts to his daughter, thus making her immune to it though she is poisonous to others, and is thus cut off from life and love. There’s also the ‘man of science’ in ‘The Birthmark’, who becomes fixated on the blood-coloured, hand-shaped birthmark of his beautiful wife. In an attempt to remove it through his science – thus rendering her perfect – he takes her to his mysterious laboratory and administers a potion that undoes the bonds holding spirit and flesh together, which kills her.

      Both of these men – like Dr Frankenstein – prefer their own arcane knowledge and the demonstration of their power to the safety and happiness of those whom they ought to love and cherish. In this way they are selfish and cold, much like the Lagadan projectors who stick to their theories no matter how much destruction and misery they may cause. And both, like Dr Frankenstein, cross the boundaries set for human beings, and dabble in matters that are either a) better left to God, or b) none of their business.

      The Lagadan projectors were both ridiculous and destructive, but in the middle of the nineteenth century the mad scientist line splits in two, with the ridiculous branch culminating in the Jerry Lewis ‘nutty professor’ comic version, and the other leading in a more tragic direction. Even in ‘alchemist’ tales like the Faustus story, the comic potential was there – Faustus on the stage was a great practical joker – but in darker sagas like Frankenstein this vein is not exploited.

      In modern times the ‘nutty professor’ trope can probably trace its origins to Thomas Hughes’ extraordinarily popular 1857 novel, Tom Brown’s School Days. There we meet a boy called Martin, whose nickname is ‘Madman’. Madman would rather do chemical experiments and explore biology than parse Latin sentences – a bent the author rather approves than not, as he sees in Madman the coming age:

      If we knew how to use our boys, Martin would have been seized upon and educated as a natural philosopher. He had a passion for birds, beasts, and insects, and knew more of them and their habits than any one in Rugby…He was also an experimental chemist on a small scale, and had made unto himself an electric machine, from which it was his greatest pleasure and glory to administer small shocks to any small boys who were rash enough to venture into his study. And this was by no means an adventure free from excitement; for besides the probability of a snake dropping on to your head or twining lovingly up your leg, or a rat getting into your breeches-pocket in search of food, there was the animal and chemical odour to be faced, which always hung about the den, and the chance of being blown up in some of the many experiments which Martin was always trying, with the most wondrous results in the shape of explosions and smells that mortal boy ever heard of.

      Despite the indulgent tone, the Lagadan comic aspects are in evidence: the chemical experiments that blow up, the stinky substances, the mess, the animal excrement, the obsession.

      The tragic or sinister mad scientist evolutionary line runs through R.L. Stevenson’s 1886 novel, Dr Jekyll and Mr Hyde, in which Dr Jekyll – another of those cross-the-forbidden-liners, with another of those mysterious laboratories – stumbles upon, or possibly inherits from Hawthorne, another of those potions that dissolve the bonds holding spirit and flesh together. But this time the potion doesn’t kill the drinker, or not at first. It does dissolve his flesh, but then it alters and re-forms both body and soul. There are now two selves, which share memory, but nothing else except the house keys. Jekyll’s potion-induced second self, Hyde, is morally worse but physically stronger, with more pronounced ‘instincts’. As this is a post-Darwinian fable, he is also hairier.

      Dr Jekyll is then betrayed by the very scientific method he has relied upon. Time after time, the mixing up of the potion and the drinking of it produce the same results; so far, so good-and-bad. But then the original supply of chemicals runs out, and the new batch doesn’t work. The boundary-dissolving element is missing, and Dr Jekyll is fatally trapped inside his furry, low-browed, murderous double. There were earlier ‘sinister double’ stories, but this one – to my knowledge – is the first in which the doubling is produced by a ‘scientific’ chemical catalyst. As with much else, this kind of transmutation has become a much-used comic book and filmic device. (The Hulk, for instance – the raging, berserk alter ego of reserved physicist Bruce Banner – came by his greenness and bulkiness through exposure to the rays from a ‘gamma bomb’ trial supervised by Dr Banner himself.)

      Next in the line comes H.G. Wells’ 1896 Dr Moreau – he of the Island, upon which he attempts, through cruel vivisection experiments, to sculpt animals into people, with appalling and eventually lethal results. Moreau has lost the well-meaning but misguided quality of the projectors: he’s possessed by a ‘passion for research’ that exists for its own sake, simply to satisfy Moreau’s own desire to explore the secrets of physiology. Like Frankenstein, he plays God – creating new beings – but like Frankenstein, the results are monstrous. And like so many of the sinister scientists who come after him, he is ‘irresponsible, so utterly careless! His curiosity, his mad, aimless investigations, drove him on…’

      From Moreau, it’s a short step to the Golden Age of mad scientists, who became so numerous in both fiction and film by the mid-twentieth century that everyone recognised the stereotype as soon as it made its appearance.

      Its lowest point is reached, quite possibly, in the B-movie called variously The Head That Wouldn’t Die or The Brain That Wouldn’t Die. The scientist in it is even more seriously depraved than usual. The head in question is that of his girlfriend; it comes off in a car accident, after which incident most men might have cried. But the mad scientist is building a Frankenstein monster out of body parts filched from a hospital, underestimating as usual the monster’s clothing size – why do those monsters’ sleeves always end halfway down their arms? – so he wraps the girl’s head in his coat and scampers off with it across the fields. Once under a glass bell with wires attached to its neck and its hair in a Bride of Frankenstein frizzle, the head gives itself to thoughts of revenge while the scientist himself haunts strip clubs in search of the perfect body to attach to it.

      There’s another element in Book Three of Gulliver’s Travels that bears mention here because it so often gets mixed into the alchemist/mad scientist sorts of tales: the theme of immortality. On the island of Luggnagg, the third in Swift’s trio of capital-L islands, Gulliver encounters the immortals – children born with a spot on their foreheads that means they will never die. At first, Gulliver longs to meet these ‘Struldbrugs’, whom he pictures as blessed: surely they will be repositories of knowledge and wisdom. But he soon finds that they are on the contrary cursed, because, like

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