Poisonous Plants and Phytochemicals in Drug Discovery. Группа авторов

Чтение книги онлайн.

Читать онлайн книгу Poisonous Plants and Phytochemicals in Drug Discovery - Группа авторов страница 20

Poisonous Plants and Phytochemicals in Drug Discovery - Группа авторов

Скачать книгу

However, there is need to extend the reach to phytotoxins which currently aren’t been exhaustively studied. Security services need to be made aware of the potential dangers that they can pose and the challenges in their remediation. In this way, it will be much easier for scientists, working alongside security service guidelines and policy, to develop appropriate remedial interventions.

      The accumulation of NHST phytotoxins in some plants may be dangerous to other plants [1]. This can be useful in selectively and strategically growing these plants to protect intended plants from invasive weeds. However, this can only be done if the intended plant–weed relationship has been studied and is well understood. If need be, biotechnology approaches to customize the relationship can be introduced. Some phytotoxins have already been reported to be significant in the management of weeds in farming [29].

      Phytotoxins have various mechanistic activities on the physiological processes of the organisms they are affecting. These include, but are not limited to, lipid biosynthesis (cyperine: Ascochyta cypericola), energy production (tentoxin: Alternaria spp.), the polymerization of actin (cytochalasins: many fungal species), and reactive oxygen species production (cercosporin: Cercospora spp.) [1]. Generally, their mechanism of action is to interact with body cells and possibly cause slow degeneration or other long‐lasting complications. Interventions against such adverse mechanisms involve blocking the mechanistic processes or introducing entirely new agents, such as known drugs, to undo or redirect the mechanisms.

      Phytotoxins are a very significant group of compounds in all sectors of society, including health, security, agriculture, and drug discovery, among others. Although many studies have been carried out, it is imperative to consider the categorization of these compounds in terms of their sources, mechanisms of action, hazards, and their benefits. In this way, there will be a very important multidisciplinary contribution to science in a way that is more meaningful to the general public.

      1 1 Berestetskiy, A.O. (2008). A review of fungal phytotoxins: from basic studies to practical use. Applied Biochemistry and Microbiology 44 (5): 453.

      2 2 Turkkan, M. and Dolar, F.S. (2008). Role of phytotoxins in plant diseases. Tarim Bilimleri Dergis 14 (1): 87–94.

      3 3 Stierle, A.A. and Stierle, D.B. (2015). Bioactive secondary metabolites produced by the fungal endophytes of conifers. Natural Product Communications 10 (10): 1671–1682.

      4 4 Yoder, O.C. (1980). Toxins in pathogenesis. Annual Review of Phytopathology 18 (1): 103–129.

      5 5 Tsuge, T., Harimoto, Y., Akimitsu, K. et al. (2013). Host‐selective toxins produced by the plant pathogenic fungus Alternaria alternata. FEMS Microbiology Reviews 37 (1): 44–66.

      6 6 Howlett, B.J. (2006). Secondary metabolite toxins and nutrition of plant pathogenic fungi. Current Opinion in Plant Biology 9 (4): 371–375.

      7 7 Wolpert, T.J., Dunkle, L.D., and Ciuffetti, L.M. (2002). Host‐selective toxins and avirulence determinants: what's in a name? Annual Review of Phytopathology 40 (1): 251–285.

      8 8 Stergiopoulos, I., Collemare, J., Mehrabi, R., and De Wit, P.J.G.M. (2013). Phytotoxic secondary metabolites and peptides produced by plant pathogenic Dothideomycete fungi. FEMS Microbiology Reviews 37 (1): 67–93.

      9 9 Rai, M., Rathod, D., Agarkar, G. et al. (2014). Fungal growth promotor endophytes: a pragmatic approach towards sustainable food and agriculture. Symbiosis 62 (2): 63–79.

      10 10 Shurigin, V., Davranov, K., Wirth, S. et al. (2018). Medicinal plants with phytotoxic activity harbour endophytic bacteria with plant growth inhibitory properties. Environmental Sustainability 1 (2): 209–215.

      11 11 Kodama, M., Akagi, Y., Takao, K., and Tsuge, T. (2015). Mycotoxins vs. phytotoxins: are they the same, or just similar? JSM Mycotoxins 65 (1): 57–62.

      12 12 Friesen, T.L., Faris, J.D., Solomon, P.S., and Oliver, R.P. (2008). Host‐specific toxins: effectors of necrotrophic pathogenicity. Cellular Microbiology 10 (7): 1421–1428.

      13 13 WHO (2019). Natural Toxins in Food. Geneva, Switzerland: World Health Organization.

      14 14 Burrows, G.E. and Tyrl, R.J. (2012). Toxic Plants of North America. Wiley.

      15 15 Quattrocchi, U. (2016). CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology (5 Volume Set). CRC Press.

      16 16 Judson, R., Richard, A., Dix, D. et al. (2008). ACToR – aggregated computational toxicology resource. Toxicology and Applied Pharmacology 233 (1): 7–13.

      17 17 Kupper, J., Waidyasekera, D., Schonenberger, W. et al. (2004). CliniTox: the computer‐based information system for poisoning in farm animals. DTW. Deutsche Tierarztliche Wochenschrift 111 (11): 433–438.

      18 18 CliniTox. 2004). www.vetpharm.uzh.ch/perldocs/toxsyqry.htm (accessed 14 October 2019).

      19 19 Günthardt, B.F., Hollender, J., Hungerbühler, K. et al. (2018). Comprehensive toxic plants – phytotoxins database and its application in assessing aquatic micropollution potential. Journal of Agricultural and Food Chemistry 66 (29): 7577–7588.

      20 20 Schmidt, U., Struck, S., Gruening, B. et al. (2009). SuperToxic: a comprehensive database of toxic compounds. Nucleic Acids Research 37(Database issue): D295–D299.

      21 21 European Food Safety Authority (2012). Compendium of botanicals reported to contain naturally occurring substances of possible concern for human health when used in food and food supplements. EFSA Journal 10 (5): 2663.

      22 22 Banerjee, P., Erehman, J., Gohlke, B.O. et al. (2015). Super natural II – a database of natural products. Nucleic Acids Research 43(Database issue): D935–D939.

      23 23 Nakamura, K., Shimura, N., Otabe, Y. et al. (2013). KNApSAcK‐3D: a three‐dimensional structure database of plant metabolites. Plant and Cell Physiology 54 (2): e4–e4.

      24 24 Afendi, F.M., Okada, T., Yamazaki, M. et al. (2011). KNApSAcK family databases: integrated metabolite–plant species databases for multifaceted plant research. Plant and Cell Physiology 53 (2): e1–e1.

      25 25 Takahashi, H., Hirai, A., Shojo, M. et al. (2011). Species metabolites relation database KNApSAcK and its multifaceted retrieval system, KNApSAcK family in general. In: Handbook of Applied Systems Toxicology (eds. D.A. Casciano and S.C. Sahu). 291‐298. Chichester, UK: Wiley.

      26 26 Najberek, K., Pusz, W., Solarz, W., and Olejniczak, P. (2018). The seeds of success: release from fungal attack on seeds may influence the invasiveness of alien impatiens. Plant Ecology 219 (10): 1197–1207.

      27 27 Oku, H. and Nakanishi, T. (1963). A toxic metabolite from Ascochyta fabae having antibiotic activity. Phytopathology 53 (10): 1321–1325.

      28 28 Berestetskiĭ, O.A. and Borovkov, A.V. (1979). Phytotoxic metabolites of soil penicillia. Mikrobiologicheskiĭ Zhurnal 41: 291–302.

      29 29 Duke, S.O., Dayan, F.E., Rimando, A.M. et al.

Скачать книгу