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Table of Contents
1 COVER
6 1 INORGANIC CHEMISTRY AND BIOCHEMISTRY ESSENTIALS 1.1 INTRODUCTION 1.2 ESSENTIAL CHEMICAL ELEMENTS 1.3 INORGANIC CHEMISTRY BASICS 1.4 ELECTRONIC AND GEOMETRIC STRUCTURES OF METALS IN BIOLOGICAL SYSTEMS 1.5 THERMODYNAMICS AND KINETICS 1.6 BIOORGANOMETALLIC CHEMISTRY 1.7 INORGANIC CHEMISTRY CONCLUSIONS 1.8 INTRODUCTION TO BIOCHEMISTRY 1.9 PROTEINS 1.10 DNA AND RNA BUILDING BLOCKS 1.11 A DESCRIPTIVE EXAMPLE: ELECTRON TRANSPORT THROUGH DNA 1.12 SUMMARY AND CONCLUSIONS 1.13 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
7 2 COMPUTER HARDWARE, SOFTWARE, AND COMPUTATIONAL CHEMISTRY METHODS 2.1 INTRODUCTION TO COMPUTER‐BASED METHODS 2.2 COMPUTER HARDWARE 2.3 COMPUTER SOFTWARE FOR CHEMISTRY 2.4 MOLECULAR MECHANICS (MM), MOLECULAR MODELING, AND MOLECULAR DYNAMICS (MD) 2.5 QUANTUM MECHANICS‐BASED COMPUTATIONAL METHODS 2.6 CONCLUSIONS ON HARDWARE, SOFTWARE, AND COMPUTATIONAL CHEMISTRY 2.7 DATABASES, VISUALIZATION TOOLS, NOMENCLATURE, AND OTHER ONLINE RESOURCES 2.8 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
8 3 IMPORTANT METAL CENTERS IN PROTEINS 3.1 IRON CENTERS IN MYOGLOBIN AND HEMOGLOBIN 3.2 IRON CENTERS IN CYTOCHROMES 3.3 IRON–SULFUR CLUSTERS IN NITROGENASE 3.4 COPPER AND ZINC IN SUPEROXIDE DISMUTASE 3.5 METHANE MONOOXYGENASE 3.6 SUMMARY AND CONCLUSIONS 3.7 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
9 4 HYDROGENASES, CARBONIC ANHYDRASES, NITROGEN CYCLE ENZYMES 4.1 INTRODUCTION 4.2 HYDROGENASES 4.3 CARBONIC ANHYDRASES 4.4 NITROGEN CYCLE ENZYMES 4.5 SUMMARY AND CONCLUSIONS 4.6 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
10 5 NANOBIOINORGANIC CHEMISTRY 5.1 INTRODUCTION TO NANOMATERIALS 5.2 ANALYTICAL METHODS 5.3 DNA ORIGAMI 5.4 METALLIZED DNA NANOMATERIALS 5.5 BIOIMAGING WITH NANOMATERIALS, NANOMEDICINE, AND CYTOTOXICITY 5.6 THERANOSTICS 5.7 NANOPARTICLE TOXICITY 5.8 SUMMARY AND CONCLUSIONS 5.9 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
11 6 METALS IN MEDICINE, DISEASE STATES, DRUG DEVELOPMENT 6.1 PLATINUM ANTICANCER AGENTS 6.2 RUTHENIUM COMPOUNDS AS ANTICANCER AGENTS 6.3 IRIDIUM AND OSMIUM ANTITUMOR AGENTS 6.4 OTHER ANTITUMOR AGENTS 6.5 BISMUTH DERIVATIVES AS ANTIBACTERIALS 6.6 DISEASE STATES, DRUG DISCOVERY, AND TREATMENTS 6.7 OTHER DISEASE STATES INVOLVING METALS 6.8 SUMMARY AND CONCLUSIONS 6.9 QUESTIONS AND THOUGHT PROBLEMS REFERENCES
