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thin-layer chromatography
8.4 Summary
References
9 Gas Chromatography
9.1 Introduction
9.2 Instrumentation
9.3 Columns and column packings
9.4 Headspace and ‘purge and trap’ analysis
9.5 Formation of artefacts in gas chromatography
9.6 Derivatization for gas chromatography
9.7 Chiral separations
9.8 Summary
References
10 Liquid Chromatography
10.1 Introduction
10.2 General considerations
10.3 Detection in liquid chromatography
10.4 Columns and column packings
10.5 Modes of liquid chromatography
10.6 Chiral separations
10.7 Derivatives for liquid chromatography
10.8 Use of liquid chromatography in analytical toxicology
10.9 Summary
References
11 Supercritical Fluid Chromatography
11.1 Introduction
11.2 General considerations
11.3 Detection in supercritical fluid chromatography
11.4 Columns and column packings
11.5 Chiral separations
11.6 Toxicological and forensic applications
11.7 Summary
References
12 Capillary Electrophoretic Techniques
12.1 Introduction
12.2 Theoretical aspects
12.3 Sample injection in capillary electrophoresis
12.4 Detection in capillary electrophoresis
12.5 Other capillary electrokinetic modes
12.6 Capillary electrophoretic techniques in analytical toxicology
12.7 Summary
References
13 Mass Spectrometry
13.1 Introduction
13.2 Instrumentation
13.3 Gas chromatography-mass spectrometry
13.4 Liquid chromatography-mass spectrometry
13.5 Supercritical fluid chromatography-mass spectrometry
13.6 Capillary electrophoresis-mass spectrometry
13.7 Direct introduction mass spectrometry
13.8 Presentation of mass spectral data
13.9 Interpretation of mass spectra
13.10 Quantitative mass spectrometry
13.11 Mass spectrometry imaging
13.12 Summary
References
14 Ion Mobility Spectrometry
14.1 Introduction
14.2 Theoretical aspects
14.3 Types of ion mobility spectrometry
14.4 Resolving power
14.5 Interfacing ion mobility spectrometry
14.6 Applications of ion mobility spectrometry in analytical toxicology
14.7 Summary
References
11 Section C: Essential Pharmacokinetics 15 Absorption, Distribution, Metabolism, and Excretion of Xenobiotics 15.1 Introduction 15.2 Movement of drugs and other xenobiotics around the body 15.3 Routes of administration 15.4 Distribution 15.5 Metabolism 15.6 Excretion 15.7 Pharmacogenetics and pharmacogenomics 15.8 Summary References 16 Pharmacokinetics 16.1 Introduction 16.2 Fundamental concepts 16.3 Absorption and elimination 16.4 Drug accumulation 16.5 Sustained-release preparations 16.6 Non-linear pharmacokinetics 16.7
