and among the exposed.Figure 3.4 Classification of observational analytical studies.Figure 3.5 Schema of an uncontrolled cross‐sectional analytical study. Black...Figure 3.6 Schema of an uncontrolled analytical cohort study. Black subjects...Figure 3.7 Models of the relationship between exposure and outcome. In (a), ...Figure 3.8 Schema of a case–control study. Black subjects are the exposed.Figure 3.9 Schema of a cohort study. Black subjects are the cases.Figure 3.10 Steps in the construction of 95% confidence intervals for the di...Figure 3.11 Steps in the construction of 95% confidence intervals for the di...Figure 3.12 Steps in the construction of 95% confidence intervals for the di...4 Chapter 4Figure 4.1 Rationale of the z‐test for large samples.Figure 4.2 Finding the exact p‐value using a statistical table of the normal...Figure 4.3 The rationale of Student’s t‐test in the case of small samples.Figure 4.4 Using the table of the t distribution to find exact p‐values.Figure 4.5 Observed and expected frequencies under H0.Figure 4.6 The chi‐square distribution under the null hypothesis for a 2 × 2...Figure 4.7 The chi‐square distribution with 1 to 10 degrees of freedom. The ...Figure 4.8 Statistical table of the chi‐square distribution.Figure 4.9 Observations in three samples of distinct populations (left panel...Figure 4.10 Procedure of ANOVA.Figure 4.11 Procedure of ANOVA with unequal sample sizes.Figure 4.12 Left ventricular ejection fraction in three groups classified ac...Figure 4.13 The F distribution with 2 and 90 degrees of freedom. The dark ar...Figure 4.14 Section of a statistical table of the F distribution.Figure 4.15 ANOVA table of the data of Figure 4.12.
5 Chapter 5Figure 5.1 Difference between two‐sided and one‐sided tests.Figure 5.2 Distribution of differences between sample means under a one‐side...Figure 5.3 The alpha and beta errors of a statistical test.Figure 5.4 Distribution of the differences between sample means under the nu...Figure 5.5 Effect of increasing sample size ratios on the statistical power ...Figure 5.6 Comparison of the distribution of the differences between means u...Figure 5.7 Commonly used transformations to the normal distribution.Figure 5.8 Rationale of a non‐parametric test for comparing two independent ...
6 Chapter 6Figure 6.1 Representation of the relationship between two interval variables...Figure 6.2 Rationale of the least squares method I.Figure 6.3 Rationale of the least squares method II.Figure 6.4 Rationale of the least‐squares method III.Figure 6.5 Sampling variation of the intercepts and slopes of regression lin...Figure 6.6 The slope m of a line connecting
7 Chapter 7Figure 7.1 Illustration of the problems of fitting a least‐squares line when...Figure 7.2 The least‐squares line fitted to the data of Figure 7.1 but with ...Figure 7.3 Transformation of the dependent variable back into proportions af...Figure 7.4 Likelihood function. The plotted values p are binomial probabilit...Figure 7.5 Illustration of the maximum likelihood estimation of regression c...Figure 7.6 Logistic regression line obtained with the method of maximum like...Figure 7.7 Results of logistic regression analysis of sex on height.Figure 7.8 Classification table of observed to predicted.Figure 7.9 The ROC curve.Figure 7.10 Development of a risk stratification system.Figure 7.11 ROC curves on the testing set and validation set.Figure 7.12 Illustration of the Hosmer–Lemeshow goodness‐of‐fit test.
8 Chapter 8Figure 8.1 Rationale and procedure of the paired t‐test.Figure 8.2 Most commonly used non‐parametric statistical tests.Figure 8.3 Overall regression line fit over clustered observations (left) an...Figure 8.4 The logrank test is used to compare two or more Kaplan–Meier curv...Figure 8.5 Illustration of the logrank test for the comparison of Kaplan–Mei...Figure 8.6 Illustration of the adjusted logrank test.Figure 8.7 Hazard rate in women diagnosed with breast cancer.Figure 8.8 Illustration of the proportionality assumption.Figure 8.9 Visual assessment of the proportionality assumption with log–log ...Figure 8.10 Example of the result of a Cox regression.
9 Chapter 9Figure 9.1 Dataset and correlation matrix of the factor analysis example.Figure 9.2 Data points representing the value of the questionnaire items def...Figure 9.3 Factor analysis. The first factor is positioned through the cente...Figure 9.4 Factor analysis. The second factor is positioned at a right angle...Figure 9.5 Factor analysis. Eigenvalues for the five factors. The eigenvalue...Figure 9.6 Scree plot.Figure 9.7 Factor loadings of the item questionnaires on the two retained fa...Figure 9.8 Orthogonal rotation of the factors shown in Figure 9.4.Figure 9.9 Oblique rotation of the factors shown in Figure 9.4.Figure 9.10 Factor loadings after orthogonal (left) and oblique rotation (ri...Figure 9.11 Covariance matrix. The diagonal elements are shaded.Figure 9.12 Relationship of Cronbach’s alpha with the number of k uncorrelat...Figure 9.13 Item analysis.Figure 9.14 Three situations with equal correlation coefficients but differe...Figure 9.15 Illustration of the results of a test–retest study with ANOVA ta...Figure 9.16 Cohen’s kappa.Figure 9.17 Weighted kappa.Figure 9.18 Bland–Altman diagram.
10 Chapter 10Figure 10.1 Conditions for the presumption of causality.Figure 10.2 Control groups of typical experimental designs and clinical tria...Figure 10.3 Pseudo‐replicates and replicates: sacrifice replication.Figure 10.4 Simple pseudo‐replication.Figure 10.5 Randomization scheme in a completely randomized design.Figure 10.6 Effect of two different treatments A and B on the same interval ...Figure 10.7 Alternative experimental design that requires only half the numb...Figure 10.8 Procedure of a two‐way ANOVA.Figure 10.9 Two‐way ANOVA table.Figure 10.10 Comparison of results in the absence of interaction between two...Figure 10.11 Procedure of ANOVA for a full factorial design.Figure 10.12 Full factorial design for the data of an experiment with two tr...Figure 10.13 ANOVA table of the data in Figure 10.12.Figure 10.14 Multiple regression analysis of the data in Figure 10.12. These...Figure 10.15 Interaction between two treatments: the difference between leve...Figure 10.16 ANOVA model II.Figure 10.17 ANOVA table for model I and model II.Figure 10.18 Full factorial ANOVA.Figure 10.19 Components of variance of a fixed effects factorial ANOVA model...Figure 10.20 Components of variance of a random effects factorial ANOVA (mod...Figure 10.21 Components of variance of a mixed effects factorial ANOVA (mode...Figure 10.22 Steps to define the expected mean squares in a mixed model ANOV...
11 Chapter 11Figure 11.1 Schematic representation of the process of allocation of experim...Figure 11.2 Procedure of a factorial ANOVA without replication for the analy...Figure 11.3 Example of an experiment with a randomized complete block design...Figure 11.4 ANOVA table from an experiment with a randomized complete block ...Figure 11.5 Experiment with a generalized randomized block design, that is, ...Figure 11.6 ANOVA table of the data in Figure 11.5.Figure 11.7 Treatment × block interaction. The differences between treatment...Figure 11.8 Examples of balanced incomplete block designs. To the left, four...Figure 11.9 Layout of an experiment based on a factorial design with randomi...Figure 11.10 Expected mean squares (left) and ANOVA table of the model and d...Figure 11.11 Latin square. On the left, the table with which the planning of...Figure 11.12 Matrix representation of the square in Figure 11.11, on the lef...Figure 11.13 Data of the experiment with a Latin square
