Fundamentals of Pharmacology. Группа авторов

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system chapter. It starts with a clear contents section indicating what can be found in the chapter and is followed by information on the associated diseases, conditions and disorders, treatment summaries and individual medication information. Focusing on constipation, find and read the description of the condition and its associated overview and management.

      The classification of the individual drug is indicated in blue (e.g. Laxatives: Bulk‐forming laxatives) with the drug name and drug monograph sited below. The drug monograph provides comprehensive information on the drug all in one concise section. Pertinent guidance is offered relating to drug action, indications and dose, adjustments and interactions, safety information, contraindications, signposting to the correct section of interactions, side effects and medicinal forms.

      In the example in Figure 2.1, the monograph depicted displays a flag, this indicates that the drug class monograph for Beta‐adrenoceptor blocker (systemic) should be consulted in tandem.

      Within the drug monograph the following are also highlighted:

       Drug classification: may be based on pharmaceutical class – for example, opioids – but may also be related to the use of the drug, such as for a cough suppressant.

       Indication and dose: all the information that relates to an individual drug; for example, drug action, indication and dose, contraindications, cautions, interactions, side effects, allergies and so on.

       Specific preparation name: if the dose varies with a specific preparation or formulation, it appears under the heading of the preparation name.

       Evidence grading: this reflects the strength of recommendation applied.

       Legal categories: applied to those preparations that are available only on a prescription issued by an appropriate practitioner and preparations that are subject to the prescription requirements of the Misuse of Drugs Act.

image
Category Description
P – pharmacy‐only medicine image A product that may only be sold in a registered pharmacy under the supervision of a registered pharmacist, e.g. bisacodyl suppositories
PoM – prescription‐only medicine image A product that may only be sold or supplied to the public on a practitioner's prescription, e.g. warfarin tablets
GSL – general sales list image A product that may be sold from a retail outlet without the supervision of a registered pharmacist, e.g. NiQuitin 2 mg medicated chewing gum
CD – controlled drug image A product that is controlled by the Misuse of Drugs Act 1971 and is listed in Schedule 2 or 3 of the Misuse of Drugs Regulations 2001 as amended, which may be subject to specific restrictions relating to supply, prescription, storage, record‐keeping, labelling, and destruction; e.g. morphine sulphate (modified release tablets) 60 mg oral tablet
ACBS – Advisory Committee on Borderline Substances A product that may be prescribed for the treatment of certain conditions. Prescriptions for these products must be endorsed ‘ACBS’. e.g. gluten‐free bread

      Paracetamol 500 mg tablets in 16 tablet packs are available as GSL and can be purchased without supervision of a pharmacist. Pharmacists may sell packs of a maximum of 32 tablets as pharmacy only (P) drugs: requiring supervision of a pharmacist. Over 32 tablets per pack are prescription only medication (PoM). This example shows that while the drug itself remains the same, other factors (in this instance, quantity) may impact on the classification of a medication. Other licensing considerations may change the legal status of the medication as well, even if the drug remains the same (Joint Formulary Committee, 2019b).

      Skills in practice

      Using the BNF index, locate docusate sodium.

       What is the drug classification?

       What are the cautions associated with this drug?

       Is this drug harmful in pregnancy?

       Is the drug available as an enema?

      Back matter

      The back matter of the BNF contains a number of appendices which offer detailed supplementary information on drug interactions, borderline substances, cautionary and advisory labels, and wound management products and elasticated garments. It also includes specific formularies for dental practitioners and the nurse prescribers formulary (for registered and qualified community practitioner prescribers).

      Interactions

      As a practitioner and professionally accountable for your actions, you must ensure that you know how to review and find out information on potential interactions. A comprehensive list of drugs with known interactions is found in Appendix 1 (as signposted to in the drug monograph). Appendix

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