Successful Drug Discovery, Volume 5. Группа авторов

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placebo‐controlled, phase 3 trial. Lancet Oncol. 20: 806–815.(c) Yang, F., Zhao, N., Hu, Y. et al. (2020). The development process: from SAHA to hydroxamate HDAC inhibitors with branched CAP region and linear linker. Chem. Biodivers. 17: e1900427.(d) Zhang, Q., Wang, S., Chen, J., and Yu, Z. (2019). Histone deacetylases (HDACs) guided novel therapies for T‐cell lymphomas. Int. J. Med. Sci. 16: 424–442.

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      110 110 Prusoff, W.H. (1959). Synthesis and biological activities of iododeoxyuridine, an analog of thymidine. Biochim. Biophys. Acta 32: 295–296.

      111 111 Clercq, E.D. and Holý, A. (2005). Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nat. Rev. Drug Discovery 4: 928–940.

      112 112 De Clercq, E., Descamps, J., De Somer, P., and Holy, A. (1978). (S)‐9‐(2,3‐Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad‐spectrum antiviral activity. Science 200: 563–565.

      113 113 Declercq, E., Holy, A., Rosenberg, I. et al. (1986). A novel selective broad‐spectrum anti‐DNA virus agent. Nature 323: 464–467.

      114 114 De Clercq, E., Sakuma, T., Baba, M. et al. (1987). Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res. 8: 261–272.

      115 115 Pradere, U., Garnier‐Amblard, E.C., Coats, S.J. et al. (2014). Synthesis of nucleoside phosphate and phosphonate prodrugs. Chem. Rev. 114: 9154–9218.

      116 116 Wittayanarakul, K., Aruksakunwong, O., Saen‐Oon, S. et al. (2005). Insights into saquinavir resistance in the G48V HIV‐1 protease: quantum calculations and molecular dynamic simulations. Biophys. J. 88: 867–879.

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      118 118 (a) Ghosh, A.K., Anderson, D.D., Weber, I.T., and Mitsuya, H. (2012). Enhancing protein backbone binding – a fruitful concept for combating drug‐resistant HIV. Angew. Chem. Int. Ed. 51: 1778–1802.(b) Ghosh, A.K., Chapsal, B.D., Weber, I.T., and Mitsuya, H. (2008). Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Acc. Chem. Res. 41: 78–86.

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      123 123 Union, O.E. (2018). Health at a Glance: Europe 2018: State of Health in the EU Cycle, vol. 2020. Paris/Brussels: OECD Publishing/European Union.

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Photograph of Oliver Plettenburg.

      Oliver Plettenburg studied chemistry at the University of Wuppertal and obtained his PhD under the supervision of Prof. Hans‐Josef Altenbach in 2000. He then moved to The Scripps Research Institute, La Jolla, to work under the guidance of Prof. Chi‐Huey Wong, where he focused on the synthesis of glycolipids. After this he joined the pharmaceutical industry at Aventis Pharma, working first in classical medicinal chemistry and developing projects from hit and lead optimization phase all the way to early clinical trials. Later he was more and more involved in establishing alternative concepts in pharmaceutical research, and lastly he held positions as “Head of Chemical Biology” and “Head of Biosensors and Chemical Probes” at Sanofi‐Aventis, Frankfurt, Germany. From 2016, Dr. Plettenburg serves as founding director of the Institute of Medicinal Chemistry of the Helmholtz Center Munich, and he is also a full professor for Medicinal Chemistry at Leibniz Universität Hannover. His research focuses on hit and lead optimization to open up new treatment options for severe diseases like diabetes, lung, inflammatory, or infectious diseases. Furthermore, he develops innovative targeted and smart drug delivery methods and works on the synthesis of novel imaging agents for in vivo monitoring of pathogenesis.

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