joint synovial fluid in response to the injection of two local anesthetic agents. Cornell Vet. 79: 25–38.50 50 Dogan, N., Erdem, A.F., Erman, Z. et al. (2004). The effects of bupivacaine and neostigmine on articular cartilage and synovium in the rabbit knee joint. J. Int. Med. Res. 32: 513–519.
51 51 Chu, C.R., Coyle, C.H., Chu, C.T. et al. (2010). In vivo effects of single intra‐articular injection of 0.5% bupivacaine on articular cartilage. J. Bone Jnt. Surg. Am. 92: 599–608.
52 52 Webb, S.T. and Ghosh, S. (2009). Intra‐articular bupivacaine: potentially chondrotoxic? Br. J. Anaesth. 102 (4): 439–441.
53 53 Piat, P., Richard, H., Beauchamp, G. et al. (2012). In vivo effects of a single intra‐articular injection of 2% Lidocaine or 0.5% Bupivacaine on articular cartilage of normal horses. Vet. Surg. 41 (8): 1002–1010.
54 54 Matsen, III F.A. and Papadonikolakis, A. (2013). Published evidence demonstrating the causation of glenohumeral chondrolysis by postoperative infusion of local anesthetic via a pain pump. J.B.J.S. 95 (12): 1126–1134.
55 55 Gulihar, A., Robati, S., Twaij, H. et al. (2015). Articular cartilage and local anaesthetic: a systematic review of the current literature. J. Ortho. 12: S200–S210.
56 56 Bailie, D.S. and Ellenbecker, T.S. (2009). Severe chondrolysis after shoulder arthroscopy: a case series. J. Shoulder Elbow Surg. 18 (5): 742–747.
57 57 Baker, J.F., Byrne, D.P., Walsh, P.M. et al. (2011). Human chondrocyte viability after treatment with local anesthetic and/or magnesium: results from an in vitro study. J. Arthro. Rel. Surg. 27 (2): 213–217.
58 58 Rubio‐Martínez, L.M., Rioja, E., Castro Martins, M. et al. (2017). Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro. B.M.C. Vet. Res. 13 (1): 318.
59 59 Lee, C.H., Wen, Z.H., Chang, Y.C. et al. (2009). Intra‐articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N‐methyl‐D‐aspartate (NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes. Osteoarth. Cart. 17 (11): 1485–1493.
60 60 Saritas, T.B., Borazan, H., Okesli, S., et al. (2015). Is intra‐articular magnesium effective for postoperative analgesia in arthroscopic shoulder surgery? Pain Res. Man. 20 (1): 35–38.
61 61 Lindegaard, C., Thomsen, M.H., Larsen, S. et al. (2010a). Analgesic efficacy of intra‐articular morphine in experimentally induced radiocarpal synovitis in horses. Vet. Anaesth. Anal. 37 (2): 171–185.
62 62 Santos, L.C.P., De Moraes, A.N., and Saito, M.E. (2009). Effects of intraarticular ropivacaine and morphine on lipopolysaccharide induced synovitis in horses. Vet. Anaesth. Anal. 36 (3): 280–286.
63 63 Lindegaard, C., Gleerup, K.B., Thomsen, M.H. et al. (2010b). Anti‐inflammatory effects of intra‐articular administration of morphine in horses with experimentally induced synovitis. Am. J. Vet. Res. 71 (1): 69–75.
64 64 Anz, A., Smith, M.J., Stoker, A. et al. (2009). The effect of bupivacaine and morphine in a coculture model of diarthrodial joints. J. Arthros. Rel. Surg. 25 (3): 225–231.
65 65 Liu, S., Zhang, Q.S., Hester, W. et al. (2012). Hyaluronan protects bovine articular chondrocytes against cell death induced by bupivacaine at supraphysiologic temperatures. Am. J. Sports Med. 40 (6): 1375–1383.
66 66 Eggleston, S.T. and Lush, L.W. (1996). Understanding allergic reactions to local anesthetics. Ann. Pharmacother. 30 (7–8): 851–857.
67 67 Malinovsky, J.M., Chiriac, A.M., Tacquard, C. et al. (2016). Allergy to local anesthetics: Reality or myth? La Presse Médicale. 45 (9): 753–757.
68 68 Saito, M., Abe, M., Furukawa, T. et al. (2014). Study on patients who underwent suspected diagnosis of allergy to amide‐type local anesthetic agents by the leukocyte migration test. Allerg. Int. 63 (2): 267–277.
69 69 Matthews, N.S., Light, G.S., Sanders, E.A. et al. (1993). Urticarial response during anesthesia in a horse. Equine Vet. J. 25 (6): 555–556.
70 70 Goldberg, G.P. and Short, C.E. (1988). Challenge in equine anesthesia: a suspected allergic reaction during acetylpromazine, guaifenesin, thiamylal, and halothane anesthesia. Equine Pract. 10: 5–10.
71 71 Choo, K.J., Simons, F.E., and Sheikh, A. (2013). Glucocorticoids for the treatment of anaphylaxis. Evidence‐Based Child Health. A Cochrane Review Journal. 1276–1294.
72 72 Dória, R.G., Valadão, C.A., Duque, J.C. et al. (2008). Comparative study of epidural xylazine or clonidine in horses. Vet. Anaesth. Anal. 35 (2): 166–172.
73 73 Skarda, R.T.and Muir, W.W. 3rd. (1996). Comparison of antinociceptive, cardiovascular, and respiratory effects, head ptosis, and position of pelvic limbs in mares after caudal epidural administration of xylazine and detomidine hydrochloride solution. Am. J. Vet. Res. 57 (9): 1338–1345.
74 74 Skarda, R.T. and Muir, W.W. 3rd. (1999). Effects of intravenously administered yohimbine on antinociceptive, cardiorespiratory, and postural changes induced by epidural administration of detomidine hydrochloride solution to healthy mares. Am. J. Vet. Res. 60 (10): 1262–1270.
75 75 Wittern, C., Hendrickson, D.A., Trumble, T. et al. (1998). Complications associated with administration of detomidine into the caudal epidural space in a horse. J. Am. Vet. Med. Assoc. 213 (4): 516–518.
76 76 Olbrich, V.H. and Mosing, M. (2003). A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse. Vet. Anaesth. Anal. 30 (3): 156–164.
77 77 Gomez de Segura, I.A, Rossi, R.D., Santos, M. et al. (1998). Epidural injection of ketamine for perineal analgesia in the horse. Vet. Surg. 27 (4): 384–391.
78 78 Natalini, C.C. and Robinson, E.P. (2000). Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am. J. Vet. Res. 61 (12): 1579–1586.
79 79 Hendrickson, D.A., Southwood, L.L., Lopez, M.J. et al. (1998). Cranial migration of different volumes of new‐methylene blue after caudal epidural injection in the horse. Equine Pract. 20: 12–14.
80 80 Valverde, A., Little, C.B., Dyson, D.H. et al. (1990). Use of epidural morphine to relieve pain in a horse. Can, Vet, J. 31 (3): 211.
81 81 Natalini, C.C. (2010). Spinal anesthetics and analgesics in the horse. Vet. Clin.: Equine Pract. 26 (3): 551–564.
82 82 Chladek, D.W. and Ruth, G.R. (1976). Isolation of Actinobacillus lignieresi from an epidural abscess in a horse with progressive paralysis. J. Am. Vet. Med. Assoc. 168 (1): 64–66.
83 83 Moudgal, V., Singal, B., Kauffman, C.A. et al. (2014). Spinal and paraspinal fungal infections associated with contaminated methylprednisolone injections. Open Forum Infect. Dis. 1 (1).
84 84 Knight, J.W., Cordingley, J.J., and Palazzo, M.G. (1997). Epidural abscess following epidural steroid and local anaesthetic injection. Anaesthesia. 52 (6): 576–578.
85 85 Yue, W.M. and Tan, S.B. (2003). Distant skip level discitis and vertebral osteomyelitis after caudal epidural injection: a case report of a rare complication of epidural injections. Spine. 28 (11): E209–211.
86 86 Simopoulos, T.T., Kraemer, J.J., Glazer, P. et al. (2008). Vertebral osteomyelitis: a potentially catastrophic outcome after lumbar epidural
