horses: a retrospective case analysis. Vet. Anaesth. Analg. 30 (3):147–155.13 13 Clutton, R.E. (1987). Unexpected responses following intravenous pethidine injection in two horses. Equine Vet. J. 19 (1): 72–73.
14 14 Santos, M. (2003). Garcia‐Iturralde, P., Herran, R. et al. Effects of alpha‐2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses. Equine Vet. J. 35 (2): 170–175.
15 15 Woodhouse, K.J., Brosnan, R.J., Nguyen, K.Q. et al. (2013). Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. J. Am. Vet. Med. Assoc. 242 (4): 533–539.
16 16 Senior, J.M., Pinchbeck G.L., Allister, R. et al. (2007) Reported morbidities following 861 anaesthetics given at four equine hospitals. Vet. Rec. 160 (12): 407–408.
17 17 Wakuno, A., Aoki, M., Kushiro, A. et al. (2017). Comparison of alfaxalone, ketamine and thiopental for anaesthetic induction and recovery in Thoroughbred horses premedicated with medetomidine and midazolam. Equine Vet. J. 49 (1): 94–98.
18 18 Young, L.E., Bartram, D.H., Diamond, M.J. et al. (1993). Clinical evaluation of an infusion of xylazine, guaifenesin and ketamine for maintenance of anaesthesia in horses. Equine Vet. J. 25 (2): 115–119.
19 19 Bettschart‐Wolfensberger, R. and Larenza, M.P. (2007). Balanced anesthesia in the equine. Clin. Tech. Equine Pract. 6 (2): 104–110.
20 20 Larenza, M.P., Kutter, A.P.N., Kummer, M. et al. (2009). Evaluation of anesthesia recovery quality after low‐dose racemic or S‐ketamine infusions during anesthesia with isoflurane in horses. Am. J. Vet. Res. 70 (6): 710–718.
21 21 Meyer, G.A., Lin, H.C., Hanson, R.R. et al. (2001). Effects of intravenous lidocaine overdose on cardiac electrical activity and blood pressure in the horse. Equine Vet. J. 33 (5): 434–437.
22 22 Dzikiti, T.B., Hellebrekers, L.J., and Dijk, P. (2003). Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress‐related hormones in horses undergoing surgery. J. Vet. Med. Ser. A. 50 (4): 190–195.
23 23 Murrell, J.C., White, K.L., Johnson, C.B. et al. (2005). Investigation of the EEG effects of intravenous lidocaine during halothane anaesthesia in ponies. Vet. Anaesth. Analg. 32 (4): 212–221.
24 24 Valverde, A., Gunkelt, C., Doherty, T.J. et al. (2005). Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses. Equine Vet. J. 37 (6): 559–564.
25 25 Valverde, A., Rickey, E., Sinclair, M. et al. (2010). Comparison of cardiovascular function and quality of recovery in isoflurane‐anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. Equine Vet. J. 42 (3): 192–199.
26 26 Engelking, L.R., Blyden, G.T., Lofstedt, J. et al. (1987). Pharmacokinetics of antipyrine, acetaminophen and lidocaine in fed and fasted horses. J. Vet. Pharmacol. Ther. 10 (1): 73–82.
27 27 Mama, K.R., Pascoe, P.J., and Steffey, E.P. Evaluation of the interaction of Mu and Kappa opioid agonists on locomotor behavior in the horse. Can. J. Vet. Res. 57 (2): 106–109.
28 28 Nolan, A.M., Besley, W., Reid, J. et al. (1994). The effects of butorphanol on locomotor activity in ponies: a preliminary study. J. Vet. Pharmacol. Ther. 17 (4): 323–326.
29 29 Fielding, C.L., Brumbaugh, G.W., Matthews, N.S. et al. (2006). Pharmacokinetics and clinical effects of a subanesthetic continuous rate infusion of ketamine in awake horses. Am. J. Vet. Res. 67 (9): 1484–1490.
30 30 Clutton, R.E. (2010). Opioid analgesia in horses. Vet. Clin. N. Am. Equine Pract. 26 (3): 493–514.
31 31 Combie, J., Shults, T., Nugent, E.C. et al. (1981). Pharmacology of narcotic analgesics in the horse: selective blockade of narcotic‐induced locomotor activity. Am. J. Vet. Res. 42 (5): 716–721.
32 32 Taylor, P.M., Hoare, H.R., de Vries, A. et al. (2016). A multicentre, prospective, randomised, blinded clinical trial to compare some perioperative effects of buprenorphine or butorphanol premedication before equine elective general anaesthesia and surgery. Equine Vet. J. 48 (4): 442–450.
33 33 Zadori, Z., Shujaa, N., Fulop, K. et al. (2007). Pre‐ and postsynaptic mechanisms in the clonidine‐ and oxymetazoline‐induced inhibition of gastric motility in the rat. Neurochem. Int. 51 (5): 297–305.
34 34 Rutkowski, J.A., Eades, S.C., and Moore, J.N. (1991). Effects of xylazine butorphanol on cecal arterial blood flow, cecal mechanical activity, and systemic hemodynamics in horses. Am. J. Vet. Res. 52 (7): 1153–1158.
35 35 Lassen, K., Soop, M., Nygren, J. et al. (2009).Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery (ERAS) Group recommendations. Arch. Surg. Chic. Ill. 144 (10): 961–969.
36 36 Wang, S., Shah, N., Philip, J. et al. (2012). Role of alvimopan (entereg) in gastrointestinal recovery and hospital length of stay after bowel resection. P T Peer‐Rev J. Formul. Manag. 37 (9): 518–525.
37 37 Boscan, P., Van Hoogmoed, L.M., Farver, T.B. et al. (2006). Evaluation of the effects of the opioid agonist morphine on gastrointestinal tract function in horses. Am. J. Vet. Res. 67 (6): 992–997.
38 38 Roger, T,. Bardon, T., and Ruckebusch, Y. (1985). Colonic motor responses in the pony: relevance of colonic stimulation by opiate antagonists. Am. J. Vet. Res. 46 (1): 31–35.
39 39 Figueiredo, J.P., Muir, W.W., and Sams, R. (2012). Cardiorespiratory, gastrointestinal, and analgesic effects of morphine sulfate in conscious healthy horses. Am. J. Vet. Res. 73 (6): 799–808.
40 40 Martin‐Flores, M., Campoy, L., Kinsley, M.A. et al. (2014). Analgesic and gastrointestinal effects of epidural morphine in horses after laparoscopic cryptorchidectomy under general anesthesia. Vet. Anaesth. Analg. 41 (4): 430–437.
41 41 Sellon, D.C., Monroe, V.L., Roberts, M.C. et al. (2001). Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses. Am. J. Vet. Res. 62 (2): 183–189.
42 42 Kamerling, S.G., Hamra, J.G., and Bagwell, C.A. (1990). Naloxone‐induced abdominal distress in the horse. Equine Vet. J. 22 (4): 241–243.
43 43 Ruckebusch, Y. and Roger, T. (1988). Prokinetic effects of cisapride, naloxone and parasympathetic stimulation at the equine ileo‐caeco‐colonic junction. J. Vet. Pharmacol. Ther. 11 (4): 322–329.
44 44 Boscan, P., Van Hoogmoed, L.M., Pypendop, B.H. et al. (2006). Pharmacokinetics of the opioid antagonist N‐methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine. Am. J. Vet. Res. 67 (6): 998–1004.
14 Complications of Loco‐Regional Anesthesia
Eva Rioja Garcia DVM, DVSc, PhD, DACVAA, DECVAA, MRCVS
Optivet Referrals, Havant, Hampshire, UK
Overview
All pain management techniques and drugs have the potential to produce complications related to the technique itself or due to the drugs’ side effects; however,
