Paphangkorakit, J. and Osborn, J.W. (1998). Discrimination of hardness by human teeth apparently not involving periodontal receptors. Arch. Oral Biol. 43 (1): 1–7.5 5 Stanley, H.R. (1989). Pulp capping: conserving the dental pulp – can it be done? Is it worth it? Oral Surg. Oral Med. Oral Pathol. 68 (5): 628–639.
6 6 Elderton, R.J. (1993). Overtreatment with restorative dentistry: when to intervene? Int. Dent. J. 43 (1): 17–24.
7 7 Schwendicke, F. and Stolpe, M. (2014). Direct pulp capping after a carious exposure versus root canal treatment: a cost‐effectiveness analysis. J. Endod. 40 (11): 1764–1770.
8 8 Murray, P.E., Garcia‐Godoy, F., and Hargreaves, K.M. (2007). Regenerative endodontics: a review of current status and a call for action. J. Endod. 33 (4): 377–390.
9 9 Nair, P.N., Duncan, H.F., Pitt Ford, T.R., and Luder, H.U. (2008). Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. Int. Endod. J. 41 (2): 128–150.
10 10 Gronthos, S., Mankani, M., Brahim, J. et al. (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 97 (25): 13625–13630.
11 11 Taha, N.A. and Khazali, M.A. (2017). Partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial. J. Endod. 43 (9): 1417–1421.
12 12 Kakehashi, S., Stanley, H.R., and Fitzgerald, R.J. (1965). The effects of surgical exposures of dental pulps in germ‐free and conventional laboratory rats. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 20: 340–349.
13 13 Bernabe, E. and Sheiham, A. (2014). Age, period and cohort trends in caries of permanent teeth in four developed countries. Am. J. Public Health 104 (7): e115–e121.
14 14 Kassebaum, N.J., Bernabe, E., Dahiya, M. et al. (2015). Global burden of untreated caries: a systematic review and metaregression. J. Dent. Res. 94 (5): 650–658.
15 15 Sengupta, K., Christensen, L.B., Mortensen, L.H. et al. (2017). Trends in socioeconomic inequalities in oral health among 15‐year‐old Danish adolescents during 1995–2013: a nationwide, register‐based, repeated cross‐sectional study. Community Dent. Oral Epidemiol. 45 (5): 458–468.
16 16 Warfvinge, J. and Bergenholtz, G. (1986). Healing capacity of human and monkey dental pulps following experimentally‐induced pulpitis. Endod. Dent. Traumatol. 2 (6): 256–262.
17 17 Brannstrom, M. and Lind, P.O. (1965). Pulpal response to early dental caries. J. Dent. Res. 44 (5): 1045–1050.
18 18 Reeves, R. and Stanley, H.R. (1966). The relationship of bacterial penetration and pulpal pathosis in carious teeth. Oral Surg. Oral Med. Oral Pathol. 22 (1): 59–65.
19 19 Mjor, I.A. and Tronstad, L. (1974). The healing of experimentally induced pulpitis. Oral Surg. Oral Med. Oral Pathol. 38 (1): 115–121.
20 20 Bergenholtz, G., Cox, C.F., Loesche, W.J., and Syed, S.A. (1982). Bacterial leakage around dental restorations: its effect on the dental pulp. J. Oral Pathol. 11 (6): 439–450.
21 21 Schwendicke, F., Frencken, J.E., Bjorndal, L. et al. (2016). Managing carious lesions: consensus recommendations on carious tissue removal. Adv. Dent. Res. 28 (2): 58–67.
22 22 El‐Helali, R., Dowling, A.H., McGinley, E.L. et al. (2013). Influence of resin‐based composite restoration technique and endodontic access on cuspal deflection and cervical microleakage scores. J. Dent. 41 (3): 216–222.
23 23 Browne, R.M., Tobias, R.S., Crombie, I.K., and Plant, C.G. (1983). Bacterial microleakage and pulpal inflammation in experimental cavities. Int. Endod. J. 16 (4): 147–155.
24 24 Cox, C.F., Keall, C.L., Keall, H.J. et al. (1987). Biocompatibility of surface‐sealed dental materials against exposed pulps. J. Prosthet. Dent. 57 (1): 1–8.
25 25 Krifka, S., Seidenader, C., Hiller, K.A. et al. (2012). Oxidative stress and cytotoxicity generated by dental composites in human pulp cells. Clin. Oral Investig. 16 (1): 215–224.
26 26 Paranjpe, A., Cacalano, N.A., Hume, W.R., and Jewett, A. (2008). Mechanisms of N‐acetyl cysteine‐mediated protection from 2‐hydroxyethyl methacrylate‐induced apoptosis. J. Endod. 34 (10): 1191–1197.
27 27 Hashem, D., Mannocci, F., Patel, S. et al. (2015). Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial. J. Dent. Res. 94 (4): 562–568.
28 28 Buchalla, W. and Attin, T. (2007). External bleaching therapy with activation by heat, light or laser – a systematic review. Dent. Mater. 23 (5): 586–596.
29 29 Leonard, R.H. Jr., Smith, L.R., Garland, G.E. et al. (2007). Evaluation of side effects and patients' perceptions during tooth bleaching. J. Esthet. Restor. Dent. 19 (6): 355–364; disc. 65–66.
30 30 Robertson, W.D. and Melfi, R.C. (1980). Pulpal response to vital bleaching procedures. J. Endod. 6 (7): 645–649.
31 31 Simon, S., Copper, P.R., Berdal, A. et al. (2009). Understanding pulp biology for routine clinical practice. ENDO Endodontic Pract. Today 3 (3): 171–184.
32 32 Lesot, H., Smith, A.J., Tziafas, D. et al. (1994). Biologically active molecules and dental tissue repair: a comparative review of reactionary and reparative dentinogenesis with the induction of odontoblast differentiation in vitro. Cells Mater. 4: 199–218.
33 33 Smith, A.J., Cassidy, N., Perry, H. et al. (1995). Reactionary dentinogenesis. Int. J. Dev. Biol. 39 (1): 273–280.
34 34 Ricucci, D., Loghin, S., and Siqueira, J.F. Jr. (2014). Correlation between clinical and histologic pulp diagnoses. J. Endod. 40 (12): 1932–1939.
35 35 Yoshiba, N., Edanami, N., Tohma, A. et al. (2018). Detection of bone marrow‐derived fibrocytes in human dental pulp repair. Int. Endod. J. 51 (11): 1187–1195.
36 36 Cassidy, N., Fahey, M., Prime, S.S., and Smith, A.J. (1997). Comparative analysis of transforming growth factor‐beta isoforms 1–3 in human and rabbit dentine matrices. Arch. Oral Biol. 42 (3): 219–223.
37 37 Smith, A.J. (2003). Vitality of the dentin–pulp complex in health and disease: growth factors as key mediators. J. Dent. Educ. 67 (6): 678–689.
38 38 Smith, A.J., Duncan, H.F., Diogenes, A. et al. (2016). Exploiting the bioactive properties of the dentin–pulp complex in regenerative endodontics. J. Endod. 42 (1): 47–56.
39 39 Cooper, P.R., Takahashi, Y., Graham, L.W. et al. (2010). Inflammation–regeneration interplay in the dentine–pulp complex. J. Dent. 38 (9): 687–697.
40 40 Couve, E., Osorio, R., and Schmachtenberg, O. (2013). The amazing odontoblast: activity, autophagy, and aging. J. Dent. Res. 92 (9): 765–772.
41 41 Huang, T.H., Yang, C.C., Ding, S.J. et al. (2005). Inflammatory cytokines reaction elicited by root‐end filling materials. J. Biomed. Mater. Res. B Appl. Biomater. 73 (1): 123–128.
42 42 Rutherford, R.B., Wahle, J., Tucker, M. et al. (1993). Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein‐1. Arch. Oral Biol. 38 (7): 571–576.
43 43 Tomson, P.L., Grover, L.M.,
