Biology as well as by Research and Development of the Next-Generation Integrated Simulation of Living Matter, a part of the Development and Use of the Next-Generation Supercomputer Project of MEXT.
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Makoto Suematsu, MD
Department of Biochemistry, School of Medicine, Keio University
35 Shinanomachi, Shinjuku-ku
Tokyo 160-8582 (Japan)
Tel. +81 3 5363 3753, Fax +81 3 5363 3466, E- Mail [email protected]
Yoshikawa T, Naito Y (eds): Gas Biology Research in Clinical Practice.
Basel, Karger, 2011, pp 6–14
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Intraluminal Gas and Gastrointestinal Diseases
Yoshihisa Urita · Toshiyasu Watanabe · Ikutaka Takemoto · Yosuke Sasaki · Tadashi Maeda · Manabu Matsumoto · Yoshiko Honda · Nagato Shimada · Hitoshi Nakajima · Motonobu Sugimoto
Department of General Medicine and Emergency Care, Toho University, School of Medicine, Tokyo, Japan
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Abstract
Gases are also produced while passing through the gastrointestinal tract, possibly resulting in abdominal symptoms although gas is continuously removed by eructation, anal evacuation, absorption through the intestinal mucosa, and bacterial consumption. It seems that 2–8 liters of air may be swallowed and eructated per day. Approximately 5–10 liters of CO2 seems to be produced and released into the lumen by chemical reactions in the upper gut. The pCO2 rises dramatically in the duodenum, resulting in diffusion of CO2 from lumen to blood, whereas CO2 in swallowed air diffuses from the blood into the stomach. The pN2 of swallowed air is slightly higher than that of venous blood in the stomach, possibly resulting in very slow absorption. Since pH2 and pCH4 are always higher in the lumen than in the blood, gases are constantly diffusing from the lumen to the blood. The calculated amount of H2 produced in the colon is 2.7–27 liters per day because H2 gas is produced at a rate of 4 liters for every 12.5 g of undigested carbohydrate. Since CH4 production occurs primarily in the left colon whereas H2 is produced primarily in the right colon, H2 produced in the left colon may be rapidly converted to CH4, possibly resulting in reduced flatus. Greater amount of gases pass through the digestive tract per day than liquid and solid contents, suggesting that impaired gas movement might be more closely associated with abdominal symptoms compared to liquid movement.
Copyright © 2011 S. Karger AG, Basel
The overall function of the digestive system is to transfer the
