Clinical Applications of Optical Coherence Tomography Angiography. Группа авторов
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Ocular imaging is critical in the management of choroidal melanoma. Ultrasonography typically shows an echolucent dome-shaped mass with choroidal excavation, vascular pulsations, and subretinal fluid [13, 14]. It also allows the measurement of tumor size, having less limitation than OCT for large tumors given its greater scan depth, but tends to overestimate tumor dimensions compared to OCT for small melanomas [26]. IVFA and ICGA can show intratumoral vessels, and when superimposed on the overlying normal retinal vessels reveals the classic “double circulation” [15–17]. However, this feature is not always present, and is seen mostly when Bruch’s rupture and retinal invasion are present, as the intratumoral vessels are masked by the retinal pigment epithelium (RPE) when it is still confined within the choroid [17]. Purely choroidal melanomas show patchy or lacy hyperfluorescence/hypercyanescence without a specific fluorescent/cyanescent pattern by IVFA or ICGA, respectively [15–17]. Fundus autofluorescence provides insights into the overall health of RPE and permits greater visualization of orange pigment in choroidal melanoma [19, 20]. OCT, on the other hand, improves the detection of subretinal fluid compared to clinical examination, and consequently provides insight into systemic prognosis, as subretinal fluid is a known risk factor for systemic metastasis [5, 19, 20]. Even if subretinal fluid is seen with choroidal nevi, Espinoza et al. [22] described an active pattern of subretinal fluid in choroidal melanomas, wherein fluid accumulates under retinal tissue with normal thickness, in contrast to a chronic pattern in choroidal nevi, when fluid accumulates under thinned retina and thickened RPE. Using enhanced depth imaging OCT (EDI-OCT) to provide better resolution of the choroid, Shields et al. [24] imaged 37 small (≤3 mm) choroidal melanomas. They reported posterior shadowing (97%) and compression of choriocapillaries (100%) in almost all tumors [24]. More importantly, the presence of shaggy photoreceptors (49 vs. 0%, p < 001), loss of ellipsoid line (65 vs. 6%, p = 0.02), loss of external limiting membrane (43 vs. 2%, p = 0.008), and overlying intraretinal edema (16 vs. 0%, p = 0.003) were features more strongly associated with choroidal melanoma than nevi [24]. Mashayekhi et al. [33] also found a remote subclinical macular edema (central macular thickness [CMT] >10 μm compared to the fellow eye) in 54% of eyes with choroidal melanoma, and even showed subclinical macular edema to be predictive of future cystoid macular edema (CME). Furthermore, subclinical macular edema was associated with larger tumors (diameter and thickness), as well as subretinal fluid [33]. Irrespective of the constellation of known clinical and imaging features of choroidal melanomas, there is no single pathognomonic sign. Hence, accurate diagnosis may require consolidation of findings obtained through history, clinical evaluation, and appropriate imaging.
OCTA Features of Choroidal Melanoma
OCTA is a non-invasive means to perform high-resolution dyeless angiography [29]. Through segmentation of OCT B-scans, OCTA also provides a layer-by-layer analysis of the retinal vasculature [28, 29]. Unlike IVFA, which only visualizes the major arterioles, major venules, and the superficial capillary network, OCTA also allows analysis of the deep capillary plexus and the radial peripapillary capillaries (RPC) in vivo, which were previously not possible [29]. Using OCTA, new metrics to describe and quantify the character of the retinal microvasculature are now available, including measurement of the foveal avascular zone (FAZ), capillary vascular density (CVD), and fractal analysis of vessel branching complexity (fractal dimensions; FD) at the superficial and deep capillary plexus, as well as RPC [34–40].
Although visualization of thin (<2 mm) structures within the scan depth of any OCT machine provides excellent images, lesions or elevated tumors with a thickness approaching or greater than the OCT scan depth can lead to segmentation errors, mirror artifacts, and generally a loss of image quality [41, 42]. Similarly, OCTA is also susceptible to the limitations above, and with a greater length of time required for imaging, it is not surprising that OCTA are more susceptible to artifacts and image degrading [43–45]. In the case of OCTA scans taken over elevated tumors, loss of vascular detail leads to diminished eye tracking capabilities and an overall loss of image quality [45]. Cennamo et al. [46] evaluated 116 patients with various choroidal tumors using EDI-OCT and OCTA imaged