rel="nofollow" href="#uc543bde1-c5a9-5757-9513-dd7dd0ecac87">p 9
Retina Service, Medical University of
South Carolina (MUSC)
167 Ashley Ave, MSC 676
Charleston SC, 29425 (USA)
E-Mail [email protected]
Barbara Scatena, p 123
Ophthalmology Clinic, Department of Medicine
and Science of Ageing
University G. D’Annunzio Chieti-Pescara
Via dei Vestini, 1, IT–66100 Chieti (Italy)
E-Mail [email protected]
Alexandre Sellam, p 116
Université Paris VI
48 Avenue Foch
FR–75116 Paris (France)
E-Mail [email protected]
Carol L. Shields, p 9
Ocular Oncology Service, Wills Eye Hospital
Thomas Jefferson University
840 Walnut Street, Suite 1440
Philadelphia, PA 19107 (USA)
E-Mail [email protected]
Lisa Toto, p 68
Ophthalmology Clinic, Department of Medicine
and Science of Ageing
University G. D’Annunzio Chieti-Pescara
Via dei Vestini, 1, IT–66100 Chieti (Italy)
E-Mail [email protected]
Nadia K. Waheed, p 1
Boston Image Reading Center
New England Eye Center at Tufts Medical Center
260 Tremont Street, Biewend Building, 9–11th Floor
Boston, MA 02116 (USA)
E-Mail [email protected]
Bandello F, Mastropasqua L, Querques G (eds): Clinical Applications of Optical Coherence Tomography Angiography. ESASO Course Series. Basel, Karger, 2020, vol 11, pp X (DOI: 10.1159/000504737)
The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. In addition, OCTA is nowadays often introduced as a routine exam in clinical practice, which has significantly modified the approach to our patients, granting the opportunity to non-invasively investigate the retinal and choroidal circulation.
For sure, OCTA technology is not without limitations and we all are still trying to interpret the information we capture. However, there is no question that this imaging technology has modified our approach to patients.
In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas. We sincerely hope that our efforts will be useful to all of you who are interested in this new technology. In a few years, we are confident that many of the limitations of this technology will be brilliantly overcome by new hardware and software applied to OCTA imaging, thus allowing the technology to be employed widely in the patient care.
We would like to thank Karger Publishers for making this book possible, and we express our sincere gratitude to all the doctors, technicians, and nurses who share their enthusiasm and efforts with us daily.
Enjoy reading!
Francesco Bandello, Milan
Leonardo Mastropasqua, Chieti
Giuseppe Querques, Milan
Bandello F, Mastropasqua L, Querques G (eds): Clinical Applications of Optical Coherence Tomography Angiography. ESASO Course Series. Basel, Karger, 2020, vol 11, pp 1–8 (DOI: 10.1159/000485295)
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Optical Coherence Tomography Angiography in Dry Age-Related Macular Degeneration
Malvika Aryaa Adnan Saifuddina, b Nadia K. Waheeda
a New England Eye Center, Tufts Medical Center, Boston, MA, USA; b The Aga Khan University Hospital, Karachi, Pakistan
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Abstract
Dry age-related macular degeneration (AMD) is characterized by changes in the outer retina, retinal pigment epithelium (RPE), and choroid. Optical coherence tomography angiography (OCTA) has proven instrumental in analyzing these changes and further understanding the pathogenesis of AMD. Early and intermediate AMD have been shown to be associated with choroidal thinning, choriocapillaris (CC) alterations under drusen, and intraretinal vascular depletion. OCTA of geographic atrophy (GA), the late stage of dry AMD, has demonstrated CC loss under the lesion itself and decreased CC flow speeds around the area of atrophy, suggesting a key role of the CC in GA pathogenesis. Much still remains to be understood about dry AMD, with an ongoing debate of whether initial changes occur in the CC, RPE, or photoreceptor layer. By allowing investigation of retinal and choroidal vascular flow changes associated with dry AMD, OCTA may pave the way for improved prediction, detection, and monitoring of dry AMD disease progression.
© 2020 S. Karger AG, Basel
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population in developed countries, and accounts for nearly 8.7% of blindness worldwide [1]. It is estimated that 30–50 million people are affected by AMD around the world, a number only anticipated to increase in the coming years.
The pathogenesis of AMD has been linked to a multitude
