for randomised trials involving molecular ...Figure 18.2 Enrichment Design (BrichD) in which subjects are selected for ra...Figure 18.3 Randomised Biomarker‐Stratified Design (BstraD)Figure 18.4 Schematic overall survival curves from a BstraD in which the bio...Figure 18.5 Strategies for analysis of a Biomarker‐Stratified Design.Figure 18.6 Anticipate T effective in all (B− and B+) patients: strate...Figure 18.7 Anticipate T effective in B− only if shown effective in B+...Figure 18.8 Decreasing value of HR(B+) (implying increasing effect size) req...Figure 18.9 Anticipate T effective in all (B− and B+) patients: strate...Figure 18.10 Anticipate T effective in B− only if shown effective in BFigure 18.11 Number of chemorefractory non‐small‐cell lung cancer patients r...19 Chapter 19Figure 19.1 Flat rule‐of‐thumb for the total sample size of a randomised two...Figure 19.2 Stepped rule‐of‐thumb total sample size, NPilot, for a two‐equal...Figure 19.3 Vital features of, and consequences from, an Internal‐Pilot stud...
20 Chapter 20Figure 20.1 Potential double triangular sequential design to compare two mat...Figure 20.2 Actual group‐sequential (Christmas tree) design to compare press...Figure 20.3 Sequential trial to compare the addition of lithium carbonate wi...Figure 20.4 Extract from the data generated by the adaptive design of Giles,...Figure 20.5 A rolling randomised trial commencing with a Standard and two te...Figure 20.6 Cumulative Kaplan–Meier curves for the event, cardiovascular dea...Figure 20.7 Illustration of how an external prior and the likelihood distrib...Figure 20.8 Three alpha‐spending functions for interim data monitoring descr...Figure 20.9 Futility analysis assuming 3‐year survival of 60% with surgery a...Figure 20.10 The Zelen single randomised consent design.Figure 20.11 The Zelen double randomised consent design.Figure 20.12 Forest plot following an overview and meta‐analysis of 11 rando...Figure 20.13 Postoperative residual refractive astigmatism at 6 months or mo...
21 AppendixFigure T1 The probability density function of a standardised Normal distribu...Figure T2 The probability density function of the Student's t‐distribution t...
Guide
5 Preface
9 Glossary
10 References
11 Index
12 Wiley End User License Agreement
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