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Table of Contents
1 Cover
7 1 Individual Participant Data Meta‐Analysis for Healthcare Research 1.1 Introduction 1.2 What Is IPD and How Does It Differ from Aggregate Data? 1.3 IPD Meta‐Analysis: A New Era for Evidence Synthesis 1.4 Scope of This Book and Intended Audience
8 Part I: Rationale, Planning, and Conduct 2 Rationale for Embarking on an IPD Meta‐Analysis Project 2.1 Introduction 2.2 How Does the Research Process Differ for IPD and Aggregate Data Meta‐Analysis Projects? 2.3 What Are the Potential Advantages of an IPD Meta‐Analysis Project? 2.4 What Are the Potential Challenges of an IPD Meta‐Analysis Project? 2.5 Empirical Evidence of Differences Between Results of IPD and Aggregate Data Meta‐Analysis Projects 2.6 Guidance for Deciding When IPD Meta‐Analysis Projects Are Needed to Evaluate Treatment Effects from Randomised Trials 2.7 Concluding Remarks 3 Planning and Initiating an IPD Meta‐Analysis Project 3.1 Introduction 3.2 Organisational Approach 3.3 Developing a Project Scope 3.4 Assessing Feasibility and ‘In Principle’ Support and Collaboration 3.5 Establishing a Team with the Right Skills 3.6 Advisory and Governance Functions 3.7 Estimating How Long the Project Will Take 3.8 Estimating the Resources Required 3.9 Obtaining Funding 3.10 Obtaining Ethical Approval 3.11 Data‐sharing Agreement 3.12 Additional Planning for Prospective Meta‐Analysis Projects 3.13 Concluding Remarks 4 Running an IPD Meta‐Analysis Project 4.1 Introduction 4.2 Preparing to Collect IPD 4.3 Initiating and Maintaining Collaboration 4.4 Obtaining IPD 4.5 Checking and Harmonising Incoming IPD 4.6 Checking the IPD to Inform Risk of Bias Assessments 4.7 Assessing and Presenting the Overall Quality of a Trial 4.8 Verification of Finalised Trial IPD 4.9 Merging IPD Ready for Meta‐Analysis 4.10 Concluding Remarks
10 Part II: Fundamental Statistical Methods and Principles 5 The Two‐stage Approach to IPD Meta‐Analysis 5.1 Introduction 5.2 First Stage of a Two‐stage IPD Meta‐Analysis 5.3 Second Stage of a Two‐stage IPD Meta‐Analysis 5.4 Meta‐regression and Subgroup Analyses 5.5 The ipdmetan Software Package 5.6 Combining IPD with Aggregate Data from non‐IPD Trials 5.7 Concluding Remarks 6 The One‐stage Approach to IPD Meta‐Analysis 6.1 Introduction 6.2 One‐stage IPD Meta‐Analysis Models Using Generalised Linear Mixed Models 6.3 One‐stage Models for Time‐to‐event Outcomes 6.4 One‐stage Models Combining Different Sources of Evidence 6.5 Reporting of One‐stage Models in Protocols and Publications 6.6 Concluding Remarks 7 Using IPD Meta‐Analysis to Examine Interactions between Treatment
