Applied Biostatistics for the Health Sciences. Richard J. Rossi

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to the corresponding probability, P(−1.29≤Z≤0.86), for the standard normal shown in Figure 2.31.

      Figure 2.31 The Z region corresponding to 700≤X≤1000.

       Example 2.39

      The distribution of IQ scores is approximately normal with µ = 100 and σ = 15. Using this normal distribution to model the distribution of IQ scores,

      1 an IQ score of 112 corresponds to a Z-value of

      2 the probability of having an IQ score of 112 or less is

      3 the probability of having an IQ score between 90 and 120 is

      4 the probability of having an IQ score of 150 or higher is

      The distribution of peak particle was reported to be approximately normal with mean particle size µ = 262 Å and standard deviation σ = 4 Å. Based on this study, the probability that a child or adolescent will have a peak particle size of less than 255 Å is

upper P left-parenthesis upper X less-than-or-equal-to 255 right-parenthesis equals upper P left-parenthesis StartFraction 255 minus 262 Over 4 EndFraction right-parenthesis equals upper P left-parenthesis upper Z less-than-or-equal-to negative 1.75 right-parenthesis equals 0.0401

      Thus, there is only a 4% chance that a child or adolescent will have peak particle size less than 255 Å.

      2.4.3 Z Scores

      The result of converting a non-standard normal value, a raw value, to a Z-value is a Z score. A Z score is a measure of the relative position a value has within its distribution. In particular, a Z score simply measures how many standard deviations a point is above or below the mean. When a Z score is negative the raw value lies below the mean of its distribution, and when a Z score is positive the raw value lies above the mean. Z scores are unitless measures of relative standing and provide a meaningful measure of relative standing only for mound-shaped distributions. Furthermore, Z scores can be used to compare the relative standing of individuals in two mound-shaped distributions.

       Example 2.41

      The weights of men and women both follow mound-shaped distributions with different means and standard deviations. In fact, the weight of a male adult in the United States is approximately normal with mean µ = 180 and standard deviation σ = 30, and the weight of a female adult in the United States is approximately normal with mean µ = 145 and standard deviation σ = 15. Given a male weighing 215 lb and a female weighing 170 lb, which individual weighs more relative to their respective population?

      The answer to this question can be found by computing the Z scores associated with each of these weights to measure their relative standing. In this case,

z Subscript male Baseline equals StartFraction 215 minus 180 Over 30 EndFraction equals 1.17

      and

z Subscript female Baseline equals StartFraction 170 minus 145 Over 15 EndFraction equals 1.67

      Since the female’s weight is 1.67 standard deviations from the mean weight of a female and the male’s weight is 1.17 standard deviations from the mean weight of a male, relative to their respective populations a female weighing 170 lb is heavier than a male weighing 215 lb.

      Glossary

upper P left-parenthesis upper A Math bar pipe bar symblom upper B right-parenthesis equals StartFraction upper P left-parenthesis upper A intersection upper B right-parenthesis Over upper P left-parenthesis upper B right-parenthesis EndFraction

      Continuous VariableA quantitative variable is a continuous variable when the variable can take on any value in one or more intervals.Discrete VariableA quantitative variable is a discrete variable when there are either a finite or a countable number of possible values for the variable.DistributionThe distribution of a variable explicitly describes how the values of the variable are distributed in terms of percentages.EventAn event is a subcollection of the outcomes in the sample space is associated with a chance experiment.Explanatory VariableAn explanatory variable is a variable that is believed to cause changes in the response variable.Independent EventsTwo events A and B are independent when P(A|B)=P(A) or P(B|A)=P(B).Interquartile RangeThe Interquartile range of a population is the distance between the 25th and 75th percentiles and will be denoted by IQR.MeanThe mean of a variable X measured on a population consisting of N units is

mu equals StartFraction sum of the values of upper X Over upper N EndFraction equals StartFraction sigma-summation upper X Over upper N EndFraction

      MedianThe median of a population is the 50th percentile of the possible values of the variable X and will be denoted by μ~.ModeThe mode of a population is the most frequent value of the variable X in the population and will be denoted by M.Multivariate VariableA collection of variables that will be measured on each unit is called a multivariate variable.Negative Predictive ValueIn a diagnostic test, the negative predictive value (NPV) is the probability of a correct negative test result, P(−|not D).Nominal VariableA qualitative variable is called a nominal variable when the values of the variable have no intrinsic ordering.Non-standard NormalA non-standard normal is any normal distribution that does not have a standard normal distribution (i.e., either μ≠ or σ≠1).OddsThe odds of an event A is odds(A)=P(A)1−P(A).Odds RatioThe odds ratio for a disease is the ratio of the odds of the disease when the risk factor is present to the odds when the risk factor is absent.

upper O upper R equals StartFraction o d d s left-parenthesis DiseaseMath bar pipe bar symblomRisk Factor Present right-parenthesis Over o d d s left-parenthesis DiseaseMath bar pipe bar symblomRisk Factor Absent right-parenthesis EndFraction

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