the two halves must possess the same qualities. Since one of them is endowed with a potentiality for unending life, and must be so endowed if the species is to persist, it is clear that the other exactly similar half must be endowed with equal potentiality.
Let us now consider how it happened that the multicellular animals and plants, which arose from unicellular forms of life, came to lose this power of living for ever.
The answer to this question is closely bound up with the principle of division of labour which appeared among multicellular organisms at a very early stage, and which has gradually led to the production of greater and greater complexity in their structure.
The first multicellular organism was probably a cluster of similar cells, but these units soon lost their original homogeneity. As the result of mere relative position, some of the cells were especially fitted to provide for the nutrition of the colony, while others undertook the work of reproduction. Hence the single group would come to be divided into two groups of cells, which may be called somatic and reproductive—the cells of the body as opposed to those which are concerned with reproduction. This differentiation was not at first absolute, and indeed it is not always so to-day. Among the lower Metazoa, such as the polypes, the capacity for reproduction still exists to such a degree in the somatic cells, that a small number of them are able to give rise to a new organism,—in fact new individuals are normally produced by means of so-called buds. Furthermore, it is well known that many of the higher animals have retained considerable powers of regeneration; the salamander can replace its lost tail or foot, and the snail can reproduce its horns, eyes, etc.
As the complexity of the Metazoan body increased, the two groups of cells became more sharply separated from each other. Very soon the somatic cells surpassed the reproductive in number, and during this increase they became more and more broken up by the principle of the division of labour into sharply separated systems of tissues. As these changes took place, the power of reproducing large parts of the organism was lost, while the power of reproducing the whole individual became concentrated in the reproductive cells alone.
But it does not therefore follow that the somatic cells were compelled to lose the power of unlimited cell-production, although in accordance with the law of heredity, they could only give rise to cells which resembled themselves, and belonged to the same differentiated histological system. But as the fact of normal death seems to teach us that they have lost even this power, the causes of the loss must be sought outside the organism, that is to say, in the external conditions of life; and we have already seen that death can be very well explained as a secondarily acquired adaptation. The reproductive cells cannot lose the capacity for unlimited reproduction, or the species to which they belong would suffer extinction. But the somatic cells have lost this power to a gradually increasing extent, so that at length they became restricted to a fixed, though perhaps very large number of cell-generations. This restriction, which implies the continual influx of new individuals, has been explained above as a result of the impossibility of entirely protecting the individual from accidents, and from the deterioration which follows them. Normal death could not take place among unicellular organisms, because the individual and the reproductive cell are one and the same: on the other hand, normal death is possible, and as we see, has made its appearance, among multicellular organisms in which the somatic and reproductive cells are distinct.
I have endeavoured to explain death as the result of restriction in the powers of reproduction possessed by the somatic cells, and I have suggested that such restriction may conceivably follow from a limitation in the number of cell-generations possible for the cells of each organ and tissue. I am unable to indicate the molecular and chemical properties of the cell upon which the duration of its power of reproduction depends: to ask this is to demand an explanation of the nature of heredity—a problem the solution of which may still occupy many generations of scientists. At present we can hardly venture to propose any explanation of the real nature of heredity.
But the question must be answered as to whether the kind and degree of reproductive power resides in the nature of the cell itself, or in any way depends upon the quality of its nutriment.
Virchow, in his ‘Cellular Pathology,’ has remarked that the cells are not only nourished, but that they actively supply themselves with food. If therefore the internal condition of the cell decides whether it shall accept or reject the nutriment which is offered, it becomes conceivable that all cells may possess the power of refusing to absorb nutriment, and therefore of ceasing to undergo further division.
Modern embryology affords us many proofs, in the segmentation of the ovum, and in the subsequent developmental changes, that the causes of the different forms of reproductive activity witnessed in cells lie in the essential nature of the cells themselves. Why does the segmentation of one half of certain eggs proceed twice as rapidly as that of the other half? why do the cells of the ectoderm divide so much more quickly than those of the endoderm? Why does not only the rate, but also the number of cells produced (so far as we can follow them) always remain the same? Why does the multiplication of cells in every part of the blastoderm take place with the exact amount of energy and rapidity necessary to produce the various elevations, folds, invaginations, etc., in which the different organs and tissues have their origin, and from which finally the organism itself arises? There can be no doubt that the causes of all these phenomena lie within the cells themselves; that in the ovum and the cells which are immediately derived from it, there exists a tendency towards a certain determined (I might almost say specific) mode and energy of cell-multiplication. And why should we regard this inherited tendency as confined to the building up of the embryo? why should it not also exist in the young, and later in the mature animal? The phenomena of heredity which make their appearance even in old age afford us proofs that a tendency towards a certain mode of cell-multiplication continues to regulate the growth of the organism during the whole of its life.
The above-mentioned considerations show us that the degree of reproductive activity present in the tissues is regulated by internal causes while the natural death of an organism is the termination—the hereditary limitation—of the process of cell-division, which began in the segmentation of the ovum.
Allow me to suggest a further consideration which may be compared with the former. The organism is not only limited in time, but also in space: it not only lives for a limited period, but it can only attain a limited size. Many animals grow to their full size long before their natural end: and although many fishes, reptiles, and lower animals are said to grow during the whole of their life, we do not mean by this that they possess the power of unlimited growth any more than that of unlimited life. There is everywhere a maximum size, which, as far as our experience goes, is never surpassed. The mosquito never reaches the size of an elephant, nor the elephant that of a whale.
Upon what does this depend? Is there any external obstacle to growth? Or is the limitation entirely imposed from within?
Perhaps you may answer, that there is an established relation between the increase of surface and mass, and it cannot be denied that these relations do largely determine the size of the body. A beetle could never reach the size of an elephant, because, constituted as it is, it would be incapable of existence if it attained such dimensions. But nevertheless the relations between surface and mass do not form the only reason why any given individual does not exceed the average size of its species. Each individual does not strive to grow to the largest possible size, until the absorption from its digestive area becomes insufficient for its mass; but it ceases to grow because its cells cannot be sufficiently nourished in consequence of its increased size. The giants which occasionally appear in the human species prove that the plan upon which man is constructed can also be carried out on a scale which is far larger than the normal one. If the size of the body chiefly depends upon amount of nutriment, it would be possible to make giants and dwarfs at will. But we know, on the contrary, that the size of the body is hereditary in families to a very marked extent; in fact so much so that the size of an individual depends chiefly upon heredity, and not upon amount of food.
These observations point to the conclusion that the size of the individual
