style="font-size:15px;"> 300 298301 299
302 300
303 301
304 302
305 303
306 304
307 305
308 306
Clinical Pharmacology and Therapeutics
Lecture Notes
Edited by
Gerard A. McKay
Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde
Glasgow, UK
Matthew R. Walters
College of Medical, Veterinary and Life Sciences
University of Glasgow
Glasgow, UK
Neil D. Ritchie
Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde
Glasgow, UK
Tenth Edition
This edition first published 2021
© 2021 John Wiley & Sons Ltd
Edition History Previous editions 1982, 1985, 1989, 1992, 1996, 2001, 2006, 2010, 2013
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of Gerard A. McKay, Matthew R. Walters, Neil D. Ritchie to be identified as the author of the editorial material in this work has been asserted in accordance with law.
Registered Office(s) John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK
For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.
Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.
Library of Congress Cataloging‐in‐Publication Data
Names: McKay, Gerard A., editor. | Walters, Matthew R., editor. | Ritchie, Neil D., (Of University of Glasgow), editor.
Title: Lecture notes. Clinical pharmacology and therapeutics / edited by Gerard A. McKay, Matthew R. Walters, Neil D. Ritchie.
Other titles: Clinical pharmacology and therapeutics
Description: 10th edition. | Hoboken, NJ : Wiley‐Blackwell, 2021. | Includes bibliographical references and index.
Identifiers: LCCN 2020028787 (print) | LCCN 2020028788 (ebook) | ISBN 9781119599951 (paperback) | ISBN 9781119599968 (adobe pdf) | ISBN 9781119599975 (epub)
Subjects: MESH: Pharmacological Phenomena | Pharmacology, Clinical–methods | Drug Therapy–methods
Classification: LCC RM300 (print) | LCC RM300 (ebook) | NLM QV 37 | DDC 615.1–dc23
LC record available at https://lccn.loc.gov/2020028787 LC ebook record available at https://lccn.loc.gov/2020028788
Cover Design: Wiley
Cover Image: © apomares/Getty Images
Preface
The successful practice of Medicine is predicated upon the ability to use drugs safely and effectively. This ability can be difficult to acquire and needs to be maintained as the range of drugs available to alleviate symptoms and to treat disease is constantly growing. As our understanding of the genome, and of the molecular basis of disease has increased, the development of new drugs with novel mechanisms of action has accelerated, expanding the available pharmacopeia for clinicians from all disciplines and therapeutic areas.
As our knowledge evolves, so must our textbooks. This tenth edition of Lecture Notes in Clinical Pharmacology has been extensively revised, refreshed and updated to provide the reader with an authoritative and modern insight into the use of drugs in the treatment of human disease.
Although
