Medical Statistics. David Machin

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Medical Statistics - David  Machin

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‘bell‐shaped’ curve or ‘Normal’ distribution shown. We presume that if we were able to look at the entire population of new‐born babies then the distribution of birthweight would have exactly the Normal shape. The Normal distribution has the properties summarised in Figure 4.10.

Graph depicts the Normal probability distribution. Graphs depict the probability distribution functions of the Normal distributions with different means and standard deviations. (a) Effect of changing mean. (b) Effect of changing standard deviation.
Standardised deviate Probability of greater deviation
Z = (Xμ)/σ (i) Area in one direction (ii) Area both directions
0 0.5000 1.0000
1.000 0.1590 0.3170
1.645 0.0500 0.0100
1.960 0.0250 0.0500
2.000 0.0230 0.0460
2.576 0.0050 0.0100
3.000 0.0013 0.0027
Graphs depict areas under the standard Normal curve. (a) 31.7-percent of observations lie outside the mean plus or minus 1 SD. (b) 4.6-percent of observations lie outside the mean plus or minus 2SD.

      As can be seen from Table 4.1, using Z values of 1.96 (that is, 1.96 SD away from the mean) then exactly 95% of the Normal distribution lies between

      Changing the multiplier 1.96 to 2.58, exactly 99% of the Normal distribution lies in the corresponding interval.

       How Do We Use the Normal Distribution?

      The Normal probability distribution can be used to calculate the probability of different values occurring. We could be interested in the probability of being within 1 SD of the mean (or outside it). We can use a Normal distribution table, which tells us the probability of being outside this value.

       Illustrative Example – Normal Distribution – Birthweights

      Using the birthweight data from the O'Cathain et al. (2002) study let us assume that the birthweight for new born babies has a Normal distribution with a mean of 3.4 kg and a standard deviation of 0.6 kg. So, what is the probability of giving birth to baby with a birthweight of 4.5 kg or higher?

Graph depicts the normal distribution curve for birthweight with a mean of 3.4 kg and SD of 0.6 kg.

      First

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