Understanding Clinical Papers. David Bowers

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of the title page rather than in the Acknowledgements, the other piece of information to look out for is advice from the journal on how to cite the paper you are reading. Typically this citation is presented in one of a number of formats that include title, authors, journal name, year, volume, and page numbers. Recently this approach has been supplemented by provision of a DOI (Digital Object Identifier) which is a standardized unique number given to many (but not all) articles, papers, and books, by some publishers, to identify a particular publication.

      Note

      1 1 You can check the impact factor of a journal at a number of websites, including, for example, the Thomson Reuters (formerly ISI) Journal Citation Reports http://isiknowledge.com/jcr (accessed 19.02.19).

      At or near the beginning of most papers you will find an Abstract and an Introduction.

      If the title of an article doesn't give you a clear enough idea of what it's about, then most papers reporting primary research data start with an Abstract – a brief summary of the whole paper that appears immediately below the title.

      The purpose of this brief summary is to help the reader decide if they want to go on to read the paper in detail, by outlining the content of the research and its main findings. A good Abstract should help the reader decide – if this study has been well conducted, then is it one about which I would be interested enough to read further?

An illustration of an example of a structured Abstract from a trial of two treatment programmes for patients with eating disorders.

      Source: From Kong (2005) with permission from John Wiley & Sons.

An illustration of an unstructured Abstract that is accompanied by a list of Keywords indicating the article's content.

      Source: From Buston (2010), © 2010, with permission from Elsevier.

      A list of Keywords may accompany the Abstract, if the journal requires it. Their purpose is to assist readers who are searching for articles on particular topics. For such a list the words may come from a standard source decided by the journal or they may be chosen by the authors themselves.

      After the Abstract comes an introductory section. Its aim is to provide some background information that makes it clear why the study described in the paper has been undertaken. The general topic area of the paper may be very familiar, but even so (perhaps especially so) the authors will probably give some summary of its importance, possibly along the lines of:

       Is it clinically important? Is it about a symptom that affects quality of life or causes major treatment difficulties?

       Is there a public health importance? Is it about an illness that represents a big burden for the community – in terms of chronic handicap, or costs to health or social services?

       Is the interest theoretical? Will further study help us to understand the causes of a condition or its consequences?

An illustration of the explanation of the background to a research study.

      Source: From Graham et al. (2000), © 2000, with permission from BMJ Publishing Group Ltd.

       Is there reference to a systematic review (see Chapters 10 and 11)? Or if not, to a search strategy which the authors used to identify relevant evidence? For an example, see Figure 2.4, taken from a study of the association between birthweight and adult blood pressure.

       Is the evidence mainly from the authors' own group or do the authors quote a range of evidence, even if it is not in support of their own views?

An illustration of an introduction explaining the rationale for the study.

      Source: Reproduced from: Shanahan et al. (2019).

       Many clinical studies are carried out because the evidence is ambiguous or contradictory. Is there a dilemma which is posed by the evidence and is it clearly spelled out in the Introduction?

      Generally speaking, the justification for a new study is that the existing evidence is unsatisfactory and a typical Introduction summarizes why, as in Figure 2.4 from a study on the use of social media to post about self‐harm. The commonest justifications for new research are that:

       Different studies have come to different conclusions about the topic and it isn't possible to come to an answer without new work.

       The evidence cannot be applied

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