Understanding Clinical Papers. David Bowers

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they are still designed to answer a question. For example, in the study illustrated in Figure 3.3 the researchers were asking the question: ‘What do people with progressive life‐limiting illness want to know about their condition – for example about its consequences and its treatment?'

      Source: From Selman et al. (2009), © 2009 BMJ Publishing Group Ltd.

An illustration of the aim of the qualitative study.

      Source: From Jones et al. (2009), © 2009 Elsevier.

      Source: Reproduced from O'Connor et al. (2017). Licensed under CC BY 4.0.

      If you cannot find a mention of the study's objectives expressed as aims or specific questions, you may yet be able to find them expressed in less clear‐cut ways. Examples include ‘exploring associations' or (worse) ‘examining issues'. You will need to be particularly careful about studies with such vague objectives: because they are not asking a specific question, it is not easy to tell whether the results are meaningful. Quantitative studies with unclear prior questions can produce results that are due to chance – especially as a result of post‐hoc or multiple testing. Qualitative studies, when they start without a clear question, do not tend to produce misleading results as much as uninteresting ones.

      Suppose now you see another child whose mother is worried that he seems unhappy and withdrawn, but she does not understand why that should be. You are likely to want to undertake some qualitative research – asking him in a relaxed and unstructured but purposeful way whether he does indeed feel unhappy, and if so why? In other words you match the design of your inquiry to the question you are asking. Now, it would be possible to have a chat with the first boy and ask him his experiences of growing up and being (perhaps) on the short side, and you could give the second child an age‐appropriate standardized mood rating scale. You will have produced results but not answers because in neither case would your method of inquiry be appropriate to your (or the mother's) specific prior questions.

      These examples introduce another question often asked of researchers: where do the aims and objectives come from? Of course, the answer is often that they come from gaps in our knowledge or theories. However, another interesting possibility is that they come from, or at least are influenced by, the views and experiences of people with personal experience of the condition being researched. This is one of the main functions of what is often called Public and Patient Involvement (PPI for short) in research – making sure that the objectives of research and the way those objectives are met will be of relevance to the ultimate consumers of research findings.

      We hope that when you read research reports you will therefore have in mind your own queries: are the aims and objectives clear, and is the researchers' chosen method the best one to meet their aims and objectives?

PART II Design Matters: What Type of Study Is It?

      Once you are clear about the aims and objectives of a study, and any hypotheses that have been posed, the next important question to ask is: ‘What sort of study did the authors undertake?' The various kinds of study design that are commonly found in clinical journals form the subject of this chapter and Chapters 511 – starting here with qualitative studies. Quantitative research, and its subcategories of design, is described across Chapters 57. Chapter 8 goes on to describe so‐called mixed methods studies, where the qualitative and quantitative approaches are combined in various ways, and Chapter 9 singles out what are called complex intervention studies for particular attention. The last two chapters in this section (Chapters 10 and 11) deal with reviewing and combining primary research studies to form secondary reviews.

      Qualitative research has proliferated greatly since the 1990s as a method for investigating illness and healthcare, becoming a regular feature in most good clinical journals. In general, the method involves observation of people's experience of illness and of healthcare, or examines how they are managing ill‐health or diagnostic investigation, without attempts to manipulate or alter either health or its care – an approach sometimes called naturalistic research. The data collected, analysed, and described in the report of a qualitative study will be based

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