polysaccharides from algae and their potential to control honeybee nosemosis. Carbohydrate Polymers 133: 213–220.44 44 Huang, J., Liu, L., Yu, Y. et al. (2006). Reduction in the blood glucose level of exopolysaccharide of Porphyridium cruentum in experimental diabetic mice. Journal of Fujian Normal University 22 (3): 77–80.
45 45 Raposo, M.F.J., Morais, A.M.M.B., and Morais, R.M.S.C. (2014). Influence of sulfate on the composition and antibacterial and antiviral properties of the exopolysaccharide from Porphyridium cruentum. Life Sciences 101 (1–2): 56–63.
46 46 Villay, A., Laroche, C., Roriz, D. et al. (2013). Optimisation of culture parameters for exopolysaccharides production by the microalga Rhodella violacea. Bioresource Technology 146: 732–735.
47 47 Chen, B., You, W., Huang, J. et al. (2010). Isolation and antioxidant property of the extracellular polysaccharide from Rhodella reticulata. World Journal of Microbiology and Biotechnology 26 (5): 833–840.
48 48 Hasui, M., Matsuda, M., Okutani, K., and Shigeta, S. (1995). In vitro antiviral activities of sulfated polysaccharides from a marine microalga (Cochlodinium polykrikoides) against human immunodeficiency virus and other enveloped viruses. International Journal of Biological Macromolecules 17 (5): 293–297.
49 49 Hasui, M., Matsuda, M., Yoshimatsu, S., and Okutani, K. (1995). Production of a lactate‐associated galactan sulfate by a dinoflagellate Gymnodinium A3. Fisheries Science 61 (2): 321–326.
50 50 Umemura, K., Yanase, K., Suzuki, M. et al. (2003). Inhibition of DNA topoisomerases I and II, and growth inhibition of human cancer cell lines by a marine microalgal polysaccharide. Biochemical Pharmacology 66 (3): 481–487.
51 51 Bae, S.‐Y., Yim, J.H., Lee, H.K., and Pyo, S. (2006). Activation of murine peritoneal macrophages by sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03): involvement of the NF‐κB and JNK pathway. International Immunopharmacology 6 (3): 473–484.
52 52 Yim, J.H., Kim, S.J., Ahn, S.H. et al. (2004). Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03. Marine Biotechnology 6 (1): 17–25.
53 53 Yim, J.H., Kim, S.J., Ahn, S.H., and Lee, H.K. (2007). Characterization of a novel bioflocculant, p‐KG03, from a marine dinoflagellate, Gyrodinium impudicum KG03. Bioresource Technology 98 (2): 361–367.
54 54 Li, P., Liu, Z., and Xu, R. (2001). Chemical characterization of the released polysaccharide from the cyanobacterium Aphanothece halophytica GR02. Journal of Applied Phycology 13 (1): 71–77.
55 55 Ou, Y., Xu, S., Zhu, D., and Yang, X. (2014). Molecular mechanisms of exopolysaccharide from Aphanothece halophytica (EPSAH) induced apoptosis in HeLa cells. PLoS One 9 (1): e87223.
56 56 Zheng, W., Chen, C., Cheng, Q. et al. (2006). Oral administration of exopolysaccharide from Aphanothece halophytica (Chroococcales) significantly inhibits influenza virus (H1N1)‐induced pneumonia in mice. International Immunopharmacology 6 (7): 1093–1999.
57 57 Zhu, L., Zhang, F., Yang, L.‐J. et al. (2016). EPSAH, an exopolysaccharide from Aphanothece halophytica GR02, improves both cellular and humoral immunity as a novel polysaccharide adjuvant. Chinese Journal of Natural Medicines 14 (7): 541–548.
58 58 Di Pippo, F., Ellwood, N.T.W., Gismondi, A. et al. (2013). Characterization of exopolysaccharides produced by seven biofilm‐forming cyanobacterial strains for biotechnological applications. Journal of Applied Phycology 25 (6): 1697–1708.
59 59 Ahmed, M., Moerdijk‐Poortvliet, T.C.W., Wijnholds, A. et al. (2014). Isolation, characterization and localization of extracellular polymeric substances from the cyanobacterium Arthrospira platensis strain MMG‐9. European Journal of Phycology 49 (2): 143–150.
60 60 Challouf, R., Trabelsi, L., Ben Dhieb, R. et al. (2011). Evaluation of cytotoxicity and biological activities in extracellular polysaccharides released by cyanobacterium Arthrospira platensis. Brazilian Archives of Biology and Technology 54 (4): 831–838.
61 61 Majdoub, H., Mansour, M.B., Chaubet, F. et al. (2009). Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochimica et Biophysica Acta (BBA) ‐ General Subjects 1790 (10): 1377–1381.
62 62 Reichert, M., Bergmann, S.M., Hwang, J. et al. (2017). Antiviral activity of exopolysaccharides from Arthrospira platensis against koi herpesvirus. Journal of Fish Diseases 40 (10): 1441–1450.
63 63 Wang, B., Liu, Q., Huang, Y. et al. (2018). Extraction of polysaccharide from spirulina and evaluation of its activities. Evidence‐Based Complementary and Alternative Medicine 2018: 1–8.
64 64 Ge, H., Zhang, J., Zhou, X. et al. (2014). Effects of light intensity on components and topographical structures of extracellular polymeric substances from Microcoleus vaginatus (Cyanophyceae). Phycologia 53 (2): 167–173.
65 65 Ge, H., Xia, L., Zhou, X. et al. (2014). Effects of light intensity on components and topographical structures of extracellular polysaccharides from the cyanobacteria Nostoc sp. Journal of Microbiology 52 (2): 179–183.
66 66 Ahmadi, A., Zorofchian Moghadamtousi, S., Abubakar, S., and Zandi, K. (2015). Antiviral potential of algae polysaccharides isolated from marine sources: a review. BioMed Research International 2015: 1–10.
67 67 Kanekiyo, K., Hayashi, K., Takenaka, H. et al. (2007). Anti‐herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue‐green alga Nostoc flagelliforme. Biological and Pharmaceutical Bulletin 30 (8): 1573–1575.
68 68 Bafana, A. (2013). Characterization and optimization of production of exopolysaccharide from Chlamydomonas reinhardtii. Carbohydrate Polymers 95 (2): 746–752.
69 69 Guzmán, S., Gato, A., Lamela, M. et al. (2003). Anti‐inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum: anti‐inflammatory and immunomodulatory activities. Phytotherapy Research 17 (6): 665–670.
70 70 Gudmundsdottir, A.B., Omarsdottir, S., Brynjolfsdottir, A. et al. (2015). Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL‐10 secretion by human dendritic cells and their ability to reduce the IL‐17+RORγt+/IL‐10+FoxP3+ ratio in CD4+ T cells. Immunology Letters 163 (2): 157–162.
71 71 Halaj, M., Paulovičová, E., Paulovičová, L. et al. (2018). Biopolymer of Dictyosphaerium chlorelloides – chemical characterization and biological effects. International Journal of Biological Macromolecules 113: 1248–1257.
72 72 Mishra, A. and Jha, B. (2009). Isolation and characterization of extracellular polymeric substances from micro‐algae Dunaliella salina under salt stress. Bioresource Technology 100 (13): 3382–3386.
73 73 Goo, B.G., Baek, G., Jin Choi, D. et al. (2013). Characterization of a renewable extracellular polysaccharide from defatted microalgae Dunaliella tertiolecta. Bioresource Technology 129: 343–350.
74 74 Trabelsi, L., Chaieb, O., Mnari, A. et al. (2016). Partial characterization and antioxidant and antiproliferative activities of the aqueous extracellular polysaccharides from the thermophilic microalgae Graesiella sp. BMC Complementary and Alternative Medicine 16 (1): 210.
75 75 Liu, X., Zhang, M., Liu, H. et al. (2018). Preliminary characterization of the structure and immunostimulatory and anti‐aging properties of the polysaccharide fraction of Haematococcus pluvialis. RSC Advances 8 (17): 9243–9252.
76 76 Ishiguro,
