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Library of Congress Cataloging-in-Publication Data
Names: Flint, S. Jane, author. | Racaniello, V. R. (Vincent R.), author. | Rall, Glenn F., author. | Hatziioannou, Theodora, author. | Skalka, Anna Marie, author.
Title: Principles of virology / Jane Flint, Department of Molecular Biology, Princeton University, Princeton, New Jersey, Vincent R. Racaniello, Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, Glenn F. Rall, Fox Chase Cancer Center, Philadelphia, Pennsylvania, Theodora Hatziioannou, The Rockefeller University, New York, New York, Anna Marie Skalka, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Description: Fifth edition. | Washington, DC : American Society for Microbiology [2020] ; Hoboken, NJ : Wiley, [2020] | Includes bibliographical references and index. | Contents: volume 1. Molecular biology—volume 2. Pathogenesis and control.
Identifiers: LCCN 2020013722 (print) | LCCN 2020013723 (ebook) | ISBN 9781683670322 (set) | ISBN 9781683672845 (v. 1 ; paperback) | ISBN 9781683672852 (v. 2 ; paperback) | ISBN 9781683672821 (v. 1 ; adobe pdf) | ISBN 9781683673606 (v. 1 ; epub) | ISBN 9781683672838 (v. 2 ; adobe pdf) | ISBN 9781683673590 (v. 2 ; epub) | ISBN 9781683670339 (adobe pdf) | ISBN 9781683673583 (epub)
Subjects: LCSH: Virology.
Classification: LCC QR360 .P697 2020 (print) | LCC QR360 (ebook) | DDC 616.9/101—dc23
LC record available at https://lccn.loc.gov/2020013722
LC ebook record available at https://lccn.loc.gov/2020013723
Illustrations and illustration concepting: Patrick Lane, ScEYEnce Studios
Cover image: Visual Science
Cover and interior design: Susan Brown Schmidler
We dedicate this book to the students, current and future scientists, physicians, and all those with an interest in the field of virology, for whom it was written.We kept them ever in mind.
We also dedicate it to our families:Jonn, Gethyn, and Amy LeedhamDoris, Aidan, Devin, and NadiaEileen, Kelsey, and AbigailPaul, Stefan, and EveRudy, Jeannie, and Chris
Oh, be wiser thou!Instructed that true knowledge leads to love.WILLIAM WORDSWORTHLines left upon a Seat in a Yew-tree1888
About the Instructor Companion Website
This book is accompanied by a companion website:
www.wiley.com/go/flint/pov5
The website includes:
PowerPoints of figures
Author podcasts
Study Questions and Answers
Preface
The enduring goal of scientific endeavor, as of all human enterprise, I imagine, is to achieve an intelligible view of the universe. One of the great discoveries of modern science is that its goal cannot be achieved piecemeal, certainly not by the accumulation of facts. To understand a phenomenon is to understand a category of phenomena or it is nothing. Understanding is reached through creative acts.
A. D. HERSHEY
Carnegie Institution Yearbook 65
All five editions of this textbook have been written according to the authors’ philosophy that the best approach to teaching introductory virology is by emphasizing shared principles. Studying the common steps of the viral reproductive cycle, illustrated with a set of representative viruses, and considering mechanisms by which these viruses can cause disease provides an integrated overview of the biology of these infectious agents. Such knowledge cannot be acquired by learning a collection of facts about individual viruses. Consequently, the major goal of this book is to define and illustrate the basic principles of virus biology.
In this information-rich age, the quantity of data describing any given virus can be overwhelming, if not indigestible, for student and expert alike. The urge to write more and more about less and less is the curse of reductionist science and the bane of those who write textbooks meant to be used by students. In the fifth edition, we continue to distill information with the intent of extracting essential principles, while providing descriptions of how the information was acquired and tools to encourage our readers’ exploration of the primary literature. Boxes are used to emphasize major principles and to provide supplementary material of relevance, from explanations of terminology to descriptions of trailblazing experiments. Our goal is to illuminate
