Principles of Virology. Jane Flint

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of Antiviral Drugs Expanding Targets for Antiviral Drug Development Two Stories of Antiviral Success Perspectives References 9 Therapeutic Viruses Introduction Phage Therapy Oncolytic Animal Viruses Gene Therapy Vaccine Vectors Perspectives References 10 Virus Evolution Virus Evolution How Do Virus Populations Evolve? The Origin of Viruses Host-Virus Relationships Drive Evolution Lessons from Paleovirology Perspectives References 11 Emergence The Spectrum of Host-Virus Interactions Encountering New Hosts: Humans Constantly Provide New Venues for Infection Common Sources for Animal-to-Human Transmission Viral Diseases That Illustrate the Drivers of Emergence The Contribution to Emergence of Mutation, Recombination, or Reassortment New Technologies Uncover Previously Unrecognized Viruses Perceptions and Possibilities Perspectives References 12 Human Immunodeficiency Virus Type I Pathogenesis Introduction HIV-1 Is a Lentivirus Entry and Transmission The Course of Infection Virus Reproduction Immune Responses to HIV-1 HIV-1 and Cancer Prospects for Treatment and Prevention Perspectives References 13 Unusual Infectious Agents Introduction Viroids Satellite Viruses and RNAs Prions and Transmissible Spongiform Encephalopathies Perspectives References APPENDIX: Epidemiology and Pathogenesis of Selected Human Viruses Adenoviruses Arenaviruses Bunyaviruses Caliciviruses Coronaviruses Filoviruses Flaviviruses Flaviviruses Flaviviruses Hepadnaviruses Herpesviruses Herpesviruses Herpesviruses Orthomyxoviruses Papillomaviruses Paramyxoviruses Paramyxoviruses Picornaviruses Picornaviruses Picornaviruses Polyomaviruses Poxviruses Reoviruses Reoviruses Retroviruses Retroviruses Rhabdoviruses Togaviruses Togaviruses Glossary Index

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