and unremitting diarrhea comes into your clinic. You’ve seen these symptoms before, but not all at once, and not to this degree. You hydrate the child, provide fever-relieving drugs, and put the child under watchful surveillance.On Thursday, three more children appear with the same symptoms, and on Friday, one of the villagers who provides care to the children of the community also develops the same symptoms. The village leaders come to you for guidance.You have all the equipment for a modest molecular biology laboratory. You call the nearest clinic for help, and they are on the way, but because of your remote location, you are on your own for at least a week. What is your first step? Of all the things you could consider in this emergency, defend why this action is more paramount than others.
PUZZLE CLUES
He developed the postulates that prove causality between a microbe and disease…except perhaps for viruses (4 letters)
An animal used to assess potential outbreaks (8 letters)
Disease manifestation of a virus infection (12 letters)
The probability that a meaningful difference or effect would be detected if it occurred (5 letters)
The number of new cases in a population in a given period (9 letters)
Disease outbreak of worldwide proportions (8 letters)
The first human virus to be identified (11 letters)
Disease transmitted from other animals to humans (8 letters)
The percentage of deaths in a specified population of infected individuals (9 letters)
A virus transmitted by mosquitos, and associated with severe birth defects (4 letters)
The host population in which a viral population is maintained (9 letters)
The cause or causes of disease (8 letters)
The total number of infected individuals in a population or area (10 letters)
The founder of vaccination, with apologies to Jenner (7 letters)
The percentage of individuals in a specified population who show symptoms of infection within a given period (9 letters)
An event when a viral disease affects a greater number of people than is usual for the area, or when a disease spreads to a new area (8 letters)
2 Barriers to Infection
An Overview of Infection and Immunity A Game of Chess Played by Masters Initiating an Infection
Successful Infections Must Modulate or Bypass Host Defenses Skin Respiratory Tract Alimentary Tract Eyes Urogenital Tract Placenta
Viral Tropism Accessibility of Viral Receptors Other Host-Virus Interactions That Regulate the Infectious Cycle
Spread throughout the Host Hematogenous Spread Neural Spread
Organ Invasion Entry into Organs with Sinusoids Entry into Organs That Lack Sinusoids Organs with Dense Basement Membranes Skin
Shedding of Virus Particles Respiratory Secretions Saliva Feces Blood Urine Semen Milk Skin Lesions Tears
LINKS FOR CHAPTER 2
Video: Interview with Dr. Neal Nathanson http://bit.ly/Virology_Nathanson
Wookie viruses http://bit.ly/Virology_Twiv250
This earth of majesty, this seat of Mars This other Eden, demi-paradise This fortress built by Nature for herself Against infection and the hand of war.
WILLIAM SHAKESPEARE, RICHARD II (ACT 2, SCENE 1)
Introduction
Microbes
