Principles of Virology, Volume 2. S. Jane Flint

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       Books

      Brock T (ed). 1961. Milestones in Microbiology. American Society for Microbiology, Washington, DC.

      Mims CA, Nash A, Stephen J. 2001. Mims’ Pathogenesis of Infectious Disease, 5th ed. Academic Press, Orlando, FL.

      Nathanson N (ed). 2007. Viral Pathogenesis and Immunity, 2nd ed. Academic Press, London, United Kingdom.

      Notkins AL, Oldstone MBA (ed). 1984. Concepts in Viral Pathogenesis. Springer-Verlag, New York, NY.

      Richman DD, Whitley RJ, Hayden FG (ed). 2009. Clinical Virology, 3rd ed. ASM Press, Washington, DC.

       Review Articles

      Bieniasz PD. 2004. Intrinsic immunity: a front-line defense against viral attack. Nat Immunol 5:1109–1115.

      Cadwell K. 2015. The virome in host health and disease. Immunity 42:805–813.

      Collins PL, Graham BS. 2008. Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 82:2040–2055.

      Coyne CB, Lazear HM. 2016. Zika virus—reigniting the TORCH. Nat Rev Microbiol 14:707–715.

      Dickey BF. 2018. What it takes for a cough to expel mucus from the airway. Proc Natl Acad Sci U S A 115:12340–12342.

      Diefenbach RJ, Miranda-Saksena M, Douglas MW, Cunningham AL. 2008. Transport and egress of herpes simplex virus in neurons. Rev Med Virol 18:35–51.

      Esteban DJ, Buller RM. 2005. Ectromelia virus: the causative agent of mousepox. J Gen Virol 86:2645–2659.

      Keele BF, Estes JD. 2011. Barriers to mucosal transmission of immunodeficiency viruses. Blood 118:839–846.

      Kennedy PGE. 1992. Molecular studies of viral pathogenesis in the central nervous system: the Linacre Lecture 1991. J R Coll Physicians Lond 26:204–214.

      Ku CC, Besser J, Abendroth A, Grose C, Arvin AM. 2005. Varicella-zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model. J Virol 79:2651–2658.

      Lancaster KZ, Pfeiffer JK. 2012. Viral population dynamics and virulence thresholds. Curr Opin Microbiol 15:525–530.

      Malamud D, Abrams WR, Barber CA, Weissman D, Rehtanz M, Golub E. 2011. Antiviral activities in human saliva. Adv Dent Res 23:34–37.

      Pereira L, Maidji E, McDonagh S, Tabata T. 2005. Insights into viral transmission at the uterine-placental interface. Trends Microbiol 13:164–174.

      Samuel MA, Diamond MS. 2006. Pathogenesis of West Nile virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol 80:9349–9360.

      Tellinghuisen TL, Evans MJ, von Hahn T, You S, Rice CM. 2007. Studying hepatitis C virus: making the best of a bad virus. J Virol 81:8853–8867.

      Virgin HW. 2007. In vivo veritas: pathogenesis of infection as it actually happens. Nat Immunol 8:1143–1147.

      Wiens ME, Wilson SS, Lucero CM, Smith JG. 2014. Defensins and viral infection: dispelling common misconceptions. PLoS Pathog 10:e1004186.

      Yan N, Chen ZJ. 2012. Intrinsic antiviral immunity. Nat Immunol 13:214–222.

      Zampieri CA, Sullivan NJ, Nabel GJ. 2007. Immunopathology of highly virulent pathogens: insights from Ebola virus. Nat Immunol 8:1159–1164.

       Papers of Special Interest

      Ida-Hosonuma M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, Yoneyama M, Fujita T,Taya C, Yonekawa H, Koike S. 2005. The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol 79:4460–4469.

       Results from this paper show that the alpha/beta interferon system plays an important role in determining tissue tropism by protecting nontarget tissues that are potentially susceptible to infection.

      Maidji E, Genbacev O, Chang HT, Pereira L. 2007. Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta. J Virol 81:4701–4712.

       This paper shows that virus interactions with cytotrophoblasts expressing receptors in the placenta are impacted differentially during development and correlate with spatially distinct sites of viral replication in maternal and fetal compartments.

      Publicover J, Ramsburg E, Robek M, Rose JK. 2006. Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha. J Virol 80:7028–7036.

       Using viral mutants and knockoutmice, the authors show the role of tumor necrosis factor alpha in the pathogenesis of vesicular stomatitis virus.

      Rambaut A, Pybus OG, Nelson MI, Viboud C, Taubenberger JK, Holmes EC. 2008. The genomic and epidemiological dynamics of human influenza A virus. Nature 453:615–619.

       The conclusions from this viral ecology paper show that new influenza lineages are seeded from a persistent reservoir, which they hypothesize is located in the tropics.

      Rivers TM. 1937. Viruses and Koch’s postulates. J Bacteriol 33:1–12.

       This paper is a classic treatise on the application and challenges of Koch’s postulates to viral infections.

      Sacher T, Podlech J, Mohr CA, Jordan S, Ruzsics Z, Reddehase MJ, Koszinowski UH. 2008. The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host. Cell Host Microbe 3:263–272.

       In evaluating viral production and spread, these authors found that the cell type producing the most viruses was not necessarily the one responsible for virus dissemination within the host.

      Smith GA, Pomeranz L, Gross SP, Enquist LW. 2004. Local modulation of plus-end transport targets herpesvirus entry and egress

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