Acceptor copolymers P5 and P6 were obtained by RAFT polymerization of BMA with methyl methacrylate (MAA) and subsequent treatment with TBAOH.
Source: From Tepper et al. [187]. © 2017 John Wiley & Sons
.
1.5.5 Materials Conclusion
Despite the early stage of development, materials scientists have used the halogen bond to construct a diverse range of LCs, ionic liquids, self‐healing polymers, and macroscopic self‐assembled gels. These initial materials provide perspective for the detailed discussions of solution‐based halogen bonding found in subsequent chapters. However, halogen bond‐based materials are still largely inspired and derived from hydrogen bond‐based materials. Surely, combining the ingenuity of the chemist with the directionality, tunability, solvent resistance, and lipophilicity of the halogen bond will produce unique materials for a variety of exciting applications. Future studies will improve the properties of halogen bonding materials and will be used to gain a greater understanding of the noncovalent interactions available to the chemist.
1.6 Conclusion
From intellectual curiosity to versatile supramolecular tool, the ascension of the halogen bond has been significant. In less than 20 years since the “rediscovery” concept article, the works of many scientists have produced a solid foundational understanding of the halogen bond. The wide breadth of fundamental studies of the halogen bond across all phases (solid, solution, gas, and in silico) has resulted in extensive (and growing) application across diverse fields. Furthermore, the success of the halogen bond has inspired a renaissance of other σ‐hole‐type interactions (e.g. chalcogen, pnictogen, and tetrel bonds) that have developed rapidly, as concepts, nomenclature, and fundamentals parallel the halogen bond.
The rise of these noncovalent forces has expanded the supramolecular landscape. As such, readers should continue to expect comparative investigations on how the halogen bond “stacks up” against other noncovalent interactions – some of which will be discussed in later chapters. These and other fundamental studies will continue to refine our understanding of the halogen bond. As the field advances, enriched understanding and computational models will lead to improved molecular designs – the prospects of which are vast. The intent of this introduction has been to provide a deeper understanding of the halogen bond that can be used to contextualize the solution discussions found in later chapters. The following chapters highlight fundamental and functional studies of the halogen bond in solution.
Acknowledgments
O.B.B., D.A.D., and E.A.J. are thankful for the support from National Science Foundation (NSF) CAREER CHE‐1555324. O.B.B., D.A.D., and E.A.J. are thankful for X‐ray core facility support by the Center for Biomolecular Structure and Dynamics CoBRE (NIH NIGMS grant P20GM103546) and the University of Montana (UM).
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