Planning and Executing Credible Experiments. Robert J. Moffat

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and the input data. The basic mathematics have not changed since that first description, but the techniques have been elaborated and extended considerably. See references at the end of this chapter and chapters 10, 11.

      Uncertainty analysis is an essential element in experiment planning, before and during execution. Uncertainty analysis is a tool by which we can identify the significance of small changes in the output. If the observed difference is larger than the derived uncertainty, this is evidence that the process being studied is not well modeled by the equations used – in other words, something is going on that we don't know about. Chapters 10 and 11 are devoted to uncertainty analysis.

      Reporting the uncertainty of every reported value is essential for others to believe our science.

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      2 Baals, D.D. and Corliss, W.R. (1981). Wind Tunnels of NASA. NASA SP‐440.

      3 Baker, M. (2016). Is there a reproducibility crisis? Nature 533: 452–454.

      4 Button, K.S., Ioannidis, J.P.A., Mokrysz, C. et al. (2013). Power failure: why small sample size undermines the reliability of neuroscience.

      5 Feynman, R. (1963). The Feynman Lectures on Physics, Volumes 1–3. MA: Addison‐Wesley.

      6 International Astronomical Union (2006). IAU 2006 General Assembly: Result of the IAU Resolution votes. https://www.iau.org/news/pressreleases/detail/iau0603.

      7 Ioannidis, J.A. (2005a). Contradicted and initially stronger effects in highly cited clinical research. JAMA 294 (2): 218–228. https://doi.org/10.1001/jama.294.2.218. PMID 16014596.

      8 Ioannidis, J.P.A. (2005b). Why most published research findings are false. PLoS Medicine 2 (8): e124.

      9 Ioannidis, J.P.A. (2012). Why science is not necessarily self‐correcting. Perspectives on Psychological Science 7 (6): 645–654.

      10 Kline, S.J. and McClintock, F.A. (1953). Describing the uncertainties in single‐sample experiments. Mechanical Engineering 75: 3–8.

      11 Muller, R. (2016). Now: The Physics of Time. NY: W.W. Norton & Company Ltd. ISBN‐13: 978‐0393285239.

      12 Penrose, R. (2005). The Road to Reality: A Complete Guide to the laws of the Universe. Knopf. ISBN‐13: 978‐0679454434.

      13 Penrose, R. (2016). Fashion, Faith, and Fantasy in the New Physics of the Universe. NJ: Princeton University Press. ISBN‐13: 978‐0‐691‐11979‐3.

      14 Penzias, A.A. and Wilson, R.W. (1965). A Measurement of Excess Antenna Temperature at 4080 Mc/s. Astrophysical Journal 142: 419–421.

      15 Pomeroy, S.R. (2012). The key to science (and life) is being wrong. Scientific American. https://blogs.scientificamerican.com/guest‐blog/the‐key‐to‐science‐and‐life‐is‐being‐wrong/.

      16 Quantum Coffee (2014). Nobel Prizes in physics: Theorists vs. experimentalists. https://quantumcoffee.wordpress.com/2014/06/08/nobel‐prizes‐in‐physics‐theorists‐vs‐experimentalists

      17 Simera, I., Moher, D., Hoey, J. et al. (2010). A catalogue of reporting guidelines for health research. European Journal of Clinical Investigation 40 (1): 35–53.

      18 Skedung, L., Arvidsson, M., Chung, J.Y. et al. (2013). Feeling Small: Exploring the Tactile Perception Limits. Scientific Reports 3: 2617.

      19 Smolin, L. (2006). The Trouble with Physics: The Rise of String Theory, the Fall of a Science, and What Comes Next. Houghton Mifflin Harcourt. ISBN‐13: 978‐0618551057.

      20  Thomson, W. (1883). Wikiquote. https://en.wikiquote.org/wiki/William_Thomson

      21 Tinsley, J., Molodtsov, M., Prevedel, R. et al. (2016). Direct detection of a single photon by humans. Nature Communications 7: 12172.

      22 Woit, P. (2006). Not Even Wrong: The Failure of String Theory and the Continuing Challenge to Unify the Laws of Physics. Basic Books. ISBN‐13: 978‐0465092765.

      1 2.1 Prepare a lab computer for dual boot: Windows and the Linux operating system. Or …

      2 2.2 Prepare a dedicated lab computer for the Linux operating system. Or Exercise 2.1.

      3 2.3 Following the guide in Appendix D3, download and install Gosset, public domain, open source, and free. Please consider this software tool essential.

      Notes

      1 1 This quotation is from a Feynman lecture at Cornell in 1964. A select portion of the lecture can be viewed at https://youtu.be/OL6‐x0modwY. A lengthier quote is given in Pomeroy (2012).

      2 2 Rather than divide a complex number into real and imaginary parts, shall we describe it as revealed and concealed parts? Our reasoning is that both parts of a complex number have reality in our universe. For example, in dynamic systems, the revealed part corresponds to position and the concealed part corresponds to velocity. Is velocity just as real as location? Of course. We, you and us, can see the location of a car relative to its surroundings. The speed (scalar) is revealed to us via the speedometer. The change of velocity is revealed to us via our inner ear. For deeper insight, Roger Penrose has provided a most compelling motivation for complex numbers in his book Road to Reality (2005, chapters 1 through 14).

      3 3 The superiority of the cooking profile trajectory is such that I (RH) witnessed a 50-person block of Asian tourists who each traveled to Japan primarily to buy a rice cooker to bring home to their country. There was insufficient room in the overhead compartments for all the rice cookers, so the flight departure was delayed 40 minutes as all the cookers were relocated to the checked-baggage compartment.

      4 4 Dr. Loyd Withrow, GM Research Labs, ca. 1953. Personal communication.

      5 5 Thank you to Dr. Ioannidis for permission to include the lists from his articles.

      6 6 Penrose trained Stephen Hawking; together they wrote a number

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