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Successful Drug Discovery
Volume 5
Edited by
János Fischer Christian Klein Wayne E. Childers
Editors
János Fischer
Richter Co., Plc.
Pharma Research
Gyömröi ut 19/21
1103 Budapest
Hungary
Christian Klein
Roche Innovation Center Zurich
Cancer Immunotherapy Discovery
Wagistrasse 10
8952 Schlieren
Switzerland
Wayne E. Childers
Temple University School of Pharmacy
Moulder Ctr. for Drug Discovery Res.
3307 N Broad Street
PA
United States
Cover
Supported by the
International Union of Pure and Applied Chemistry (IUPAC)
Chemistry and Human Health Division
PO Box 13757
Research Triangle Park, NC 2770‐3757
USA
All books published by Wiley‐VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.
Library of Congress Card No.:
applied for
British Library Cataloguing‐in‐Publication Data
A catalogue record for this book is available from the British Library.
Bibliographic information published by the Deutsche Nationalbibliothek
The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at <http://dnb.d-nb.de>.
© 2021 WILEY‐VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany
All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.
Print ISBN: 978‐3‐527‐34754‐4
ePDF ISBN: 978‐3‐527‐82685‐8
ePub ISBN: 978‐3‐527‐82686‐5
oBook ISBN: 978‐3‐527‐82687‐2
Advisory Board Members
Jonathan Baell
(Monash University)
Gabriele Costantino
(University of Parma)
Jagath Reddy Junutula
(ModMab Therapeutics)
Kazumi Kondo
(Otsuka)
Roberto Pellicciari
(TES Pharma S.r.l.)
David Rotella
(Montclair State University)
Preface
The International Union of Pure and Applied Chemistry (IUPAC) supports the publication of the book series Successful Drug Discovery as projects. In these books, experts and key inventors describe and analyze different aspects of drug discovery.
The fifth volume of Successful Drug Discovery has the same structure as the previous volumes. New drug discoveries will be discussed in three parts: Part I: General Aspects, Part II: Drug Class Studies, and Part III: Case Studies encompassing both small‐molecule drugs and biologics.
The editors thank the advisory board members: Jonathan Baell (Monash University), Gabriele Costantino (University of Parma), Jagath R. Junutula (ModMab Therapeutics), Kazumi Kondo (Otsuka Pharmaceutical), Roberto Pellicciari (TES Pharma), and David Rotella (Montclair State University). Special thanks go to the following reviewers who helped both the authors and the editors: John M. Beals, András Kern, Béla Kiss, Thomas Luebbers, Gerd Schnorrenberg, William N. Washburn, and Peng Wu. Special thanks are due to Juergen Stohner for his review from the viewpoint of the IUPAC Interdivisional Committee on Terminology, Nomenclature, and Symbols (ICTNS).
Part
