the knowledge of action of electrical signaling inside the cells is inadequate and warrants further research into cellular behavior in response to applied mechanical forces.
It is evident from the ongoing discussion that neither of these hypotheses could provide conclusive evidence on the detailed nature of the biological mechanism of OTM. Histological, histochemical, and immunohistochemical studies performed in the twentieth century, as well as early in the twenty‐first century, have demonstrated that multiple phenomena, both physical and chemical, are involved in the process of tooth movement. When mechanical forces are applied, cells, as well as the ECM of the PDL and alveolar bone, respond concomitantly, resulting in tissue remodeling activities. During early phases of tooth movement, PDL fluids are shifted, producing cell and matrix distortions as well as interactions between these tissue elements. In response to these physicochemical events and interactions, cytokines, growth factors, colony stimulating factors, and vasoactive neurotransmitters are released, initiating and sustaining the remodeling activity, which facilitates the movement of teeth. A detailed discussion on these molecules along with the mechanisms of their operation is provided in Chapter 3.
Concluding remarks
Our ancestors noticed, two or three millennia ago, that malposed teeth can be straightened by the application of mechanical force to the crowns of those teeth. With the passage of time, a large variety of devices had been designed in order to correct malocclusions, and were usually claimed to be superior to other appliances aiming at the same targets. The inability to determine which of those gadgets would be best for clinical use was limited by the paucity of biological information that could support most of the claims made by their inventors. However, there was a breakthrough with the introduction of histology into orthodontics at the start of the twentieth century. The visualization of the response of tissues and cells to mechanical forces opened the gate to thoughtful proposals of hypotheses, to explain the reason for tooth movement. The two prevailing dogmas during the following decades were the “pressure–tension” and the “bone‐bending” hypotheses. Other hypotheses stemming from these two focused on the roles of the dynamics of tissue fluids and evoked electric potentials in the strained tissues in OTM. Altogether, each of these hypotheses improves our understanding of the fundamental principles of OTM. Additional building blocks to assist in crafting a unified theory based on biological evidence have been derived from research at the cellular and molecular levels, which is reviewed in the next chapter.
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