Biological Mechanisms of Tooth Movement. Группа авторов

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and angiogenesis response to orthodontic forces

      Blood flowing through the tooth is confronted with a unique environment. The dental pulp is encased within a rigid, noncompliant shell and its survival is dependent on the blood vessels that access the interior of the tooth through the apical foramen. As a consequence of these unusual environmental constraints, changes in pulpal blood flow or vascular tissue pressure can have serious implications for the health of the dental pulp (Kim, 1990).

      OTM causes inflammatory reactions in the periodontium and dental pulp, which will stimulate release of various biochemical mediators. The perception of orthodontic pain is the result of a hyperalgesic response elicited by these mediators. Periodontal pain is caused by a process involving the development of pressure, ischemia, inflammation, and edema. Burstone (1964) identified both immediate and delayed pain responses, which begin a few hours after the application of an orthodontic force and last for approximately 5 days (Scheurer et al., 1996). Krukemeyer et al. (2009) concluded from a survey conducted on 118 patients that 58.5% indicated that they experienced pain for a few days after their appointment, out of which only 26.5% of the patients used pain medication immediately following and 1 day after the last appointment.

In vitro studies (stimulated by substance P) In vivo studies
Prostaglandin E2 (PGE2) CGRP and SP
IL‐1α and β Blood flow
IL‐6 Apoptosis
TNF‐α Angiogenesis
RANKL Aspartate amino transferase activity

      Painful sensations result, in part, from the stretching and distortion of tissues by the mechanical loads (Stephenson, 1992), as well as from interactions of multiple inflammatory mediators with local pain receptors (Davies and MacIntyre, 1992). According to a review by Krishnan (2007), the perception of orthodontic pain is due to the changes in blood flow caused by the appliances, correlated with the release and presence of various substances, such as SP, histamine, enkephalin, dopamine, serotonin, glycine, glutamate, gamma‐aminobutyric acid, PGs, leukotrienes, and cytokines (Yamasaki et al., 1984; Davidovitch et al., 1988; Davidovitch, 1991; Alhashimi et al., 2001).

      Processing of complex information arising from mechanical force application induces recruitment of neurons, which act by way of chemical mediators as modulators of the effector response to the stimulus. The neurogenic inflammation, which evolves following activation of an orthodontic appliance, starts with the release of neuropeptides from strained afferent nerve endings in and around the treated teeth, as well as in the central nervous system. The simultaneous release of neuropeptides, peripherally and centrally, elicits a painful response (Vandevska‐Radunovic, 1999). Kato et al. (1996) examined the distribution of nerve fibers containing NFP, CGRP, VIP, and NPY in the PDL of the rat first molar after mechanical force application. They observed an increase in the number of NFP‐ and CGRP‐containing nerve fibers at both the stretched and the compressed sides of the PDL after 3 days of force application, which returned to normal after 14 days. They concluded that NFP‐, CGRP‐, VIP‐, and NPY‐containing nerve fibers play an important role in blood flow regulation, tissue remodeling, and modulation of pain perception during tooth movement. This finding was in accordance with earlier reports. Norevall et al. (1995) also agreed about the role of CGRP and SP in tooth movement but contradicted the role of other neuropeptides such as VIP and NPY.

      Currently, several treatment modalities have been applied for the relief of orthodontic pain, such as mechanical and behavioural approaches, and low‐level laser therapy (Long et al., 2016). Mechanical approaches have been proposed to relieve orthodontic pain including vibration, chewing gums, biting wafers, and acupuncture. The proposed mechanism for vibration, chewing gum, and biting wafers lies in the fact that mechanical stimuli activate mechanoreceptors that transmit tactile signals while suppressing the transmission of painful signals (Guyton and Hall, 2000). However, its mechanism remains large unknown.

      Behavioural approaches that are applied to relieve orthodontic pain include cognitive behavioral therapy (CBT), physical activity, and music therapy. CBT, a form of psychotherapy, uses several treatment sessions to correct the patient’s negative attitude and decrease their anxiety. As a result, orthodontic pain is relieved in clinical practice (Wang et al., 2015). Music therapy and physical activity distract patient’s attention via the insular cortex‐mediated neural pathway (Xu et al., 2013; Sandhu and Sandhu 2015). However, the mechanisms are not convincing.

      Low‐level laser therapy has been extensively applied for pain relief in both medical and dental practice (Huang et al., 2015; Landucci et al., 2016). A large body of evidence has confirmed the effectiveness of low‐level laser therapy in alleviating orthodontic pain (Tortamano et al., 2009; Artés‐Ribas et al., 2013; Eslamian et al., 2014). PGE2 and IL‐1β production in stretched human PDL cells was inhibited by laser irradiation in vitro (Shimizu et al., 1995). Therefore, it is concluded that low‐energy laser irradiation may be useful in reducing the levels of inflammation and pain, as well as decreasing orthodontic treatment time by accelerating the pace of tooth movement, without causing any side effects.

      Many

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