142, 339–347.55 Fristad, I., Kvinnsland, I. H., Jonsson, R. and Heyeraas, K. J. (1997) Effect of intermittent long‐lasting electrical tooth stimulation on pulpal blood flow and immunocompetent cells: A hemodynamic and immunohistochemical study in young rat molars. Experimental Neurology 146, 230–239.
56 Funakoshi, M., Yamaguchi, M., Asano, M. et al. (2013) Effect of compression force on apoptosis in human periodontal ligament cells. Journal of Hard Tissue Biology 22, 41–50.
57 Garlet, T. P., Coelho, U., Repeke, C. E. et al. (2008) Differential expression of osteoblast and osteoclast chemmoatractants in compression and tension sides during orthodontic movement. Cytokine 42, 330–335.
58 Garlet, T. P., Coelho, U., Silva, J. S. and Garlet, G.P. (2007) Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. European Journal of Oral Sciences 115, 355–362.
59 Goodwin, G. H. and Johns, E. W. (1977) The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteins. Methods in Cell Biology 16, 257–267.
60 Guyton, A. C. and Hall, J.E. (2000) Somatic sensations: II pain, headache, and thermal sensations, in Textbook of Medical Physiology, 10th edn. Elsevier Sciences, Singapore.
61 Hamersky, P., Weimar, A. and Taintor, J. (1980) The effect of orthodontic force application on the pulpal tissue respiration rate in the human premolar. American Journal of Orthodontics 77, 368–378.
62 Harris, E. F., Boggan, B. W. and Wheeler, D. A. (2001) Apical root resorption in patients treated with comprehensive orthodontics. Journal of the Tennessee Dental Association 81, 30–33.
63 Harris, E. F., Kineret, S. E. and Tolley, E. A. (1997) A heritable component for external apical root resorption in patients treated orthodontically. American Journal of Orthodontics and Dentofacial Orthopedics 111, 301–309.
64 Hatano, K., Ishida, Y., Yamaguchi, H. et al. (2018) The chemokine receptor type 4 antagonist, AMD3100, interrupts experimental tooth movement in rats. Archives of Oral Biology 86, 35–39.
65 Hayashi, N., Yamaguchi, M., Nakajima, R. et al. (2012) T‐helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces. Oral Diseases 18, 375–388.
66 He, Y., Macarak, E. J., Korostoff, J. M. and Howard, P. S. (2004) Compression and tension: differential effects on matrix accumulation by periodontal ligament fibroblasts in vitro. Connective Tissue Research 45, 28–39.
67 Hendrick, J. P. and Hartl, F. U. (1993) Molecular chaperone functions of heat‐shock proteins. Annual Review of Biochemistry 62, 349–384.
68 Henry, J. L. and Weinmann, J. P. (1951) The pattern of resorption and repair of human cementum. Journal of the American Dental Association 42, 270–290.
69 Huang, Z., Ma, J., Chen, J. et al. (2015) The effectiveness of low‐level laser therapy for nonspecific chronic low back pain: a systematic review and meta‐analysis. Arthritis Research and Therapy 17, 360.
70 Hughes, S. R., Williams, T. J. and Brain, S. D. (1990) Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. European Journal of Pharmacology 191, 481–484.
71 Iglesias‐Linares, A., Yanez‐Vico, R. M., Ballesta, S. et al. (2012) Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post‐orthodontic root resorption in endodontic and their contralateral vital control teeth differently. International Endodontic Journal 45, 1018–1026.
72 Iglesias‐Linares, A. and Hartsfield, J.K. Jr. (2017) Cellular and molecular pathways leading to external root resorption. Journal of Dental Research 96, 145–152.
73 Ishizu, T., Osoegawa, M., Mei, F. J. et al. (2005) Intrathecal activation of the IL‐17/IL‐8 axis in opticospinal multiple sclerosis. Brain 128, 988–1002.
74 Johnson, R. B., Wood, N. and Serio, F. G. (2004) Interleukin‐11 and IL‐17 and the pathogenesis of periodontal disease. Journal of Periodontology 75, 37–43.
75 Jones, S. J. and Boyde, A. (1972) A study of human root cementum surfaces as prepared for and examined in the scanning electron microscope. Zeitschrift für Zellforschung und mikroskopische Anatomie 130, 318–337.
76 Kanaan, R. A. and Kanaan, L. A. (2006) Transforming growth factor beta1, bone connection. Medical Science Monitor 12, RA164–169.
77 Kanzaki, H., Chiba, M., Arai, K. et al. (2006) Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement. Gene Therapy 13, 678–685.
78 Kanzaki, H., Chiba, M., Shimizu, Y. and Mitani, H. (2002) Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up‐regulation via prostaglandin E2 synthesis. Journal of Bone and Mineral Research 17, 210–220.
79 Kanzaki, H., Chiba, M., Takahashi, I. et al. (2004) Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. Journal of Dental Research 83, 920–925.
80 Kato, J., Wakisaka, S. and Kurisu, K. (1996) Immunohistochemical changes in the distribution of nerve fibers in the periodontal ligament during experimental tooth movement of the rat molar. Acta Anatomica, 157, 53–62.
81 Killiany, D. M. (1999) Root resorption caused by orthodontic treatment: an evidence‐based review of literature. Seminars in Orthodontics 5, 128–133.
82 Kim, S. (1990) Neurovascular interactions in the dental pulp in health and inflammation. Journal of Endodontics 16, 48–53.
83 Kim, Y. S., Lee, Y. M., Park, J. S. et al. (2010) SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells. Journal of Cellular Biochemistry 111, 1310–1320.
84 Kobayashi, E.T., Hashimoto, F., Kobayashi, Y. et al. (1999) Force‐induced rapid changes in cell fate at midpalatal suture cartilage of growing rats. Journal of Dental Research 78, 1495–1504.
85 Kobayashi, Y., Hashimoto, F., Miyamoto, H. et al. (2000) Force‐induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor beta and osteoprotegerin expression. Journal of Bone and Mineral Research 15, 1924–1934.
86 Kojima, T., Yamaguchi, M. and Kasai, K. (2006) Substance P stimulates release of RANKL via COX‐2 expression in human dental pulp cells. Inflammation Research 55, 78–84.
87 Kotake, S., Udagawa, N., Takahashi, K. et al. (1999) IL‐17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. Journal of Clinical Investigation 103, 1345–1352.
88 Krishnan, V. (2007) Orthodontic pain: from causes to management – a review. European Journal of Orthodontics 29, 170–179.
89 Krishnan, V. and Davidovitch, Z. (2006a) Cellular, molecular, and tissue‐level reactions to orthodontic force. American Journal of Orthodontics and Dentofacial Orthopedics 129, 469.e1–32.
90 Krishnan, V. and Davidovitch, Z. (2006b) The effect of drugs on orthodontic tooth movement. Orthodontics and Craniofacial Research 9, 163–171.
91 Krukemeyer, A. M., Arruda, A. O. and Inglehart, M. R. (2009) Pain and orthodontic treatment. The Angle Orthodontist 79, 1175–1181.
92 Kvinnsland, I. and Kvinnsland, S. (1990) Changes in CGRP‐immunoreactive
