Evidence in Medicine. Iain K. Crombie
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Evidence in Medicine
The Common Flaws, Why They Occur and How to Prevent Them
Iain K Crombie
University of Dundee
Dundee, Scotland, UK
This edition first published 2021
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Library of Congress Cataloging‐in‐Publication Data
Names: Crombie, I. K., author.
Title: Evidence in medicine : the common flaws, why they occur and how to prevent them / Iain K. Crombie.
Description: First edition. | Hoboken, NJ : John Wiley & Sons, Inc., 2021. | Includes bibliographical references and index.
Identifiers: LCCN 2020051750 (print) | LCCN 2020051751 (ebook) | ISBN 9781119794141 (paperback) | ISBN 9781119794189 (adobe pdf) | ISBN 9781119794196 (epub)
Subjects: MESH: Research Design–standards | Randomized Controlled Trials as Topic | Systematic Reviews as Topic | Evidence‐Based Practice–standards | Treatment Outcome
Classification: LCC R852 (print) | LCC R852 (ebook) | NLM W 20.5 | DDC 610.72–dc23
LC record available at https://lccn.loc.gov/2020051750 LC ebook record available at https://lccn.loc.gov/2020051751
Cover Design: Wiley
Cover Image: © Govindanmarudhai/DigitalVision Vectors/Getty Images
Preface
Evidence is central to the practice of medicine. The amount of published medical evidence is immense, but there are widespread concerns about the quality of many studies. Deficiencies in the conduct of research studies often result in misleading estimates of the benefits of treatments, so that ineffective treatments may be used in clinical practice. In addition, many studies are wasted because they have been so poorly designed and conducted.
This book explores the nature of the deficiencies and flaws in the evidence about the effectiveness of treatments. It is the result of a career‐long interest in medical evidence. A recent career change provided an opportunity to read the extensive literature on research quality that has emerged in recent years.