Basic Virology. Martinez J. Hewlett

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      In Memoriam

      Edward K. Wagner

      (May 4, 1940 to January 21, 2006)

      It was one of those telephone calls that you do not want to receive. Each of us, that weekend in late January, heard of the untimely passing of our colleague, co‐author, collaborator, mentor, and friend, Ed Wagner. Ed will be remembered for his many contributions to the teaching of virology and for his research contributing to our understanding of the intricacies of the herpesviruses. From his graduate work at MIT, through his postdoctoral research at the University of Chicago, and on to his professorship at the University of California, Irvine, Ed was a passionate champion for the most rigorous and critical thinking and the most dedicated teaching, setting a standard for the discipline of virology. Beyond the laboratory and the classroom, Ed loved life to the fullest, with his family and friends. The last time we were together as a writing team, in the fall of 2005, we all remember an intense day of work in a conference room at UCI, followed by an evening of touring some of Ed’s favorite haunts in the Southern California coastal towns he called home. It is with those thoughts etched into our memories that we dedicate this edition of Basic Virology to Edward K. Wagner.

      Basic Virology

      Fourth Edition

      Martinez “Marty” Hewlett

       University of New Mexico Taos, NM, USA

      David Camerini

       Center for Virus Research University of California, Irvine Irvine, CA, USA

      David C. Bloom

       Department of Molecular Genetics and Microbiology University of Florida Gainesville, FL, USA

      This fourth edition first published 2021

      © 2021 John Wiley & Sons, Inc.

      Edition History:

      1e; (1999, Wiley‐Blackwell) 2e; (2003, John Wiley & Sons), 3e; (2007, Wiley‐Blackwell).

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Marty Hewlett, David Camerini, and David Bloom to be identified as the authors of this work has been asserted in accordance with law.

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      While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

      Library of Congress Cataloging‐in‐Publication Data Names: Hewlett, Martinez “Marty”, author. | Camerini, David, author. | Bloom, David (David C.), author. Title: Basic virology / Marty Hewlett, David Camerini, David Bloom. Description: Fourth edition. | Hoboken, NJ: Wiley‐Blackwell, 2021. | Preceded by: Basic virology / Edward K. Wagner … [et al.]. 3rd ed. 2008. | Includes bibliographical references and index. Identifiers: LCCN 2020026463 (print) | LCCN 2020026464 (ebook) | ISBN 9781119314059 (paperback) | ISBN 9781119314042 (adobe pdf) | ISBN 9781119314066 (epub) Subjects: MESH: Virus Diseases–virology | Viruses–pathogenicity | Virus Replication | Genome, Viral Classification: LCC QR360 (print) | LCC QR360 (ebook) | NLM WC 500 | DDC 579.2–dc23 LC record available at https://lccn.loc.gov/2020026463 LC ebook record available at https://lccn.loc.gov/2020026464

      Cover Design: Wiley Blackwell

      Cover Image: © Wah Chiu

      Preface to the First Edition

      Viruses have historically flickered in and out of the public consciousness. In the eight years since we finished the first edition of Basic Virology much has happened, both in the world and in virology, to fan the flames of this awareness.

      In

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