characteristic features, exposure effects, hazard mechanisms, risk assessment and management.
This book focuses on current trends to deliver therapeutic agents into targeted specific cells, cellular compartments, tissues, and organs by using nanoparticulate carriers; applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano‐nutraceuticals, dermatology, gene therapy, etc.; nanotoxicology with focus on nanomedicine, landscapes of in vitro and in vivo toxicological testing; regulatory framework in nanotechnology and medicine; future aspects in toxicity and safety assessment of nanotechnology, etc. Also, the book identifies the knowledge gaps related to nanomaterials’ safety which tends to be the greatest hurdle in obtaining benefits of nanomedicine in healthcare. Now that we are entering a new phase from academic development to proven clinical value, it is very important for specialists in the field to find all the information on these aspects together in a book, to see what the current stage is, what the problems are and what viable solutions are being proposed for the future in this field.
This book contains valuable chapters written by professionals and experts on the diverse aspects of nanotechnology in medicine with insights into the toxicological and safety issues owing to interaction with biological systems and the environment. The chapters have been divided into four different parts. Part I: Nanomedicine: Nanotoxicological Insights – aims to enrich the understandings of nanotoxicological features of nanomedicine. It provides an introductory overview of nanomedicine and nanotoxicology progressing further toward recent advances in research and development dealing with microbial biopolymers and their derivatives as nanotechnological instruments for medicine. Part II deals with Nanoparticles: Toxicity and Safety. The recent technological and manufacturing innovations have led to the enhanced use of nanoparticles for diverse applications. However, this has also preceded the risks allied with its exposure. This part imparts the perceptions of toxicity and safety aspects of selenium nanoparticles, the impact of nanoparticles on protozoa, moving ahead in the direction of toxicity and safety facets of metallic, polymeric, and mesoporous silica nanoparticles. Part III is focused on Nanotoxicology and Drug delivery. Augmenting the mechanistic insights for risk assessment of employing nanomaterials in drug delivery is the need of the hour. Consequently, this part targets the toxicity and safety aspects of incorporating nanocarriers for gene delivery, brain delivery, parenteral delivery, dermatological delivery, etc. Lastly, it encompasses the current scenario and future road map for nanotoxicity and nanosafety assessment of nanocarriers. The last part (Part IV: Nanotechnology, Ethics and Regulatory Framework) emphasizes harmonizing the procedures for safety evaluation globally and ascertaining unambiguous regulations as well as standard protocols. The part thus delivers the perceptions of nanoethics and the regulatory framework of nanotechnology in medicine.
This book has been planned, authored, and structured for the wide spectrum of multisectoral audiences of scholars, students, practitioners, and policymakers with adequate coverage. It is intended to be a reference resource that will meet the needs of academicians, clinicians, as well as graduate and postgraduate students from nearly every field of science and engineering – toxicology, biotechnology, chemistry, physics, genetics, medical science, material science and engineering, environmental science and environmental engineering. For researchers working in the fields of nanotechnology, nanomaterials and nanocarriers, nanoengineering, nanobiotechnologies, nanomedicine and biopharmaceuticals, and other similar fields, it would be very useful.
We are highly thankful to the authors for their excellent work in providing cutting‐edge information on the subject of their respective chapters. Their efforts will certainly enhance and update the readers' knowledge of the toxicity and safety aspects of nanomedicine. Further, we would like to express our sincere thanks to the publishers and authors of the chapters whose research work has been mentioned in the book. We are also thankful to Dr. Julia Squarr, Sarah Mellor, Rosie Hayden, Tom Marriott, and the Wiley team for their substantial cooperation and efforts in producing this book.
Last but not the least, we believe that this edited book would inspire engagement and intervention by concerted and collaborative action by appropriate bodies to shape the nanoworld and deliver innovative solutions to address daunting medical challenges.
25 April 2021
Mahendra Rai
Amravati, MH, India
Mrunali Patel
Anand, GJ, India
Rashmin Patel
Anand, GJ, India
List of Contributors
Nayelen Sayuri Aizawa Department of Biotechnology Engineering School of Lorena (EEL) São Paulo University (USP) Lorena, São Paulo, Brazil
Amit Alexander National Institute of Pharmaceutical Education and Research (NIPER GUWAHATI) Department of Pharmaceuticals Ministry of Chemicals & Fertilizers Near Dr. Bhupen Hazarika Regional Govt. Film & Television Institute Sila Village, Nizsundarighopa Changsari, Kamrup (R) Guwahati, Assam, India
Thais Francine Ribeiro Alves Laboratory of Biomaterials and Nanotechnology (LaBNUS) University of Sorocaba Sorocaba, Brazil Sorocaba Technology Park, Innovation Agency Sorocaba, Brazil
Mansi Athalye Department of Pharmaceutics and Pharmaceutical Technology L. M. College of Pharmacy Ahmedabad, GJ, India
Fernando Batain Laboratory of Biomaterials and Nanotechnology (LaBNUS) University of Sorocaba Sorocaba, Brazil
Bappaditya Chatterjee Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management (SPPSPTM) NMIMS University Mumbai, MH, India
Marco Vinícius Chaud Laboratory of Biomaterials and Nanotechnology (LaBNUS) University of Sorocaba Sorocaba, Brazil Sorocaba Technology Park, Innovation Agency Sorocaba, Brazil
Iti Chauhan Department of Pharmaceutics I.T.S College of Pharmacy, Muradnagar Ghaziabad, UP, India
Namdev Dhas Department of Pharmaceutics Institute of Pharmacy Nirma University Ahmedabad, GJ, India
Nataliya N. Dremina Irkutsk Scientific Center of Surgery and Traumatology Irkutsk, Russia
Nidhi Dubey School of pharmacy Devi Ahilya Vishwavidyalaya Indore, MP, India
Nitin Dubey IPS Academy College of Pharmacy Indore, MP, India
Wilson Engelmann Graduate Program in Public Law University of Vale do Rio dos Sinos – UNISINOS São Leopoldo, Brazil Corporate Law and Business University of Vale do Rio dos Sinos – UNISINOS São Leopoldo, Brazil
Anuradha Ketan Gajjar L. M. College of Pharmacy Ahmedabad, GJ, India
Fernanda Gonçalves Department of Biotechnology Engineering School of Lorena (EEL) São Paulo University (USP) Lorena, São Paulo, Brazil
Kartik Hariharan Department of Pharmaceutics Institute of Pharmacy Nirma University Ahmedabad, GJ, India
Raquel Von Hohendorff Graduate Program in Public Law University of
