H., Aleckovic, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., Garcia-Santos, G., Ghajar, C., Nitadori-Hoshino, A., Hoffman, C., Badal, K., Garcia, B.A., Callahan, M.K., Yuan, J., Martins, V.R., Skog, J., Kaplan, R.N., Brady, M.S., Wolchok, J.D., Chapman, P.B., Kang, Y., Bromberg, J., and Lyden, D. (2012). Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18: 883–891.97 Pu, C., Huang, H., Wang, Z., Zou, W., Lv, Y., Zhou, Z., Zhang, Q., Qiao, L., Wu, F., and Shao, S. (2018). Extracellular vesicle-associated miR-21 and miR-144 are markedly elevated in serum of patients with hepatocellular carcinoma. Front. Physiol. 9: 930.
98 Que, R., Ding, G., Chen, J., and Cao, L. (2013). Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma. World J. Surg. Oncol. 11: 219.
99 Rabinowits, G., Gercel-Taylor, C., Day, J.M., Taylor, D.D., and Kloecker, G.H. (2009). Exosomal microRNA: A diagnostic marker for lung cancer. Clin. Lung. Cancer 10: 42–46.
100 Raimondo, F., Morosi, L., Corbetta, S., Chinello, C., Brambilla, P., Della Mina, P., Villa, A., Albo, G., Battaglia, C., Bosari, S., Magni, F., and Pitto, M. (2013). Differential protein profiling of renal cell carcinoma urinary exosomes. Mol. Biosyst. 9: 1220–1233.
101 Rasanen, K. and Vaheri, A. (2010). Activation of fibroblasts in cancer stroma. Exp. Cell Res. 316: 2713–2722.
102 Rodriguez, M., Silva, J., Lopez-Alfonso, A., Lopez-Muniz, M.B., Pena, C., Dominguez, G., Garcia, J.M., Lopez-Gonzalez, A., Mendez, M., Provencio, M., Garcia, V., and Bonilla, F. (2014). Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer. Genes. Chromosomes Cancer 53: 713–724.
103 Sandfeld-Paulsen, B., Jakobsen, K.R., Baek, R., Folkersen, B.H., Rasmussen, T.R., Meldgaard, P., Varming, K., Jorgensen, M.M., and Sorensen, B.S. (2016). Exosomal proteins as diagnostic biomarkers in lung cancer. J. Thorac. Oncol. 11: 1701–1710.
104 Sato, S., Vasaikar, S., Eskaros, A., Kim, Y., Lewis, J.S., Zhang, B., Zijlstra, A., and Weaver, A.M. (2019). EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling. JCI Insight 4.
105 Sekita, Y., Wagatsuma, H., Nakamura, K., Ono, R., Kagami, M., Wakisaka, N., Hino, T., Suzuki-Migishima, R., Kohda, T., Ogura, A., Ogata, T., Yokoyama, M., Kaneko-Ishino, T., and Ishino, F. (2008). Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat. Genet. 40: 243–248.
106 Shan, T., Chen, S., Chen, X., Lin, W.R., Li, W., Ma, J., Wu, T., Ji, H., Li, Y., Cui, X., and Kang, Y. (2017). Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells. Int. J. Oncol. 50: 121–128.
107 Sharma, P. and Allison, J.P. (2015). The future of immune checkpoint therapy. Science 348: 56–61.
108 Shiga, K., Hara, M., Nagasaki, T., Sato, T., Takahashi, H., and Takeyama, H. (2015). Cancer-associated fibroblasts: Their characteristics and their roles in tumor growth. Cancers (Basel) 7: 2443–2458.
109 Shiino, S., Matsuzaki, J., Shimomura, A., Kawauchi, J., Takizawa, S., Sakamoto, H., Aoki, Y., Yoshida, M., Tamura, K., Kato, K., Kinoshita, T., Kitagawa, Y., and Ochiya, T. (2019). Serum miRNA-based prediction of axillary lymph node metastasis in breast cancer. Clin. Cancer Res. 25: 1817–1827.
110 Shimomura, A., Shiino, S., Kawauchi, J., Takizawa, S., Sakamoto, H., Matsuzaki, J., Ono, M., Takeshita, F., Niida, S., Shimizu, C., Fujiwara, Y., Kinoshita, T., Tamura, K., and Ochiya, T. (2016). Novel combination of serum microRNA for detecting breast cancer in the early stage. Cancer Sci. 107: 326–334.
111 Simons, M. and Raposo, G. (2009). Exosomes–vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 21: 575–581.
112 Skog, J., Wurdinger, T., Rijn, V.A.N., Meijer, S., Gainche, D.H., Sena-Esteves, L., Curry, W.T., Jr., Carter, B.S., Krichevsky, A.M., and Breakefield, X.O. (2008). Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10: 1470–1476.
113 Srivastava, A., Moxley, K., Ruskin, R., Dhanasekaran, D.N., Zhao, Y.D., and Ramesh, R. (2018). A non-invasive liquid biopsy screening of urine-derived exosomes for miRNAs as biomarkers in endometrial cancer patients. AAPS J. 20: 82.
114 Sruthi, T.V., Edatt, L., Raji, G.R., Kunhiraman, H., Shankar, S.S., Shankar, V., Ramachandran, V., Poyyakkara, A., and Kumar, S.V.B. (2018). Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis. J. Cell Physiol. 233: 3498–3514.
115 Subra, C., Grand, D., Laulagnier, K., Stella, A., Lambeau, G., Paillasse, M., De Medina, P., Monsarrat, B., Perret, B., Silvente-Poirot, S., Poirot, M., and Record, M. (2010). Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J. Lipid. Res. 51: 2105–2120.
116 Sun, B., Li, Y., Zhou, Y., Ng, T.K., Zhao, C., Gan, Q., Gu, X., and Xiang, J. (2019). Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer. J. Cell. Physiol. 234: 1416–1425.
117 Taylor, D.D. and Gercel-Taylor, C. (2008). MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 110: 13–21.
118 Thery, C., Witwer, K.W., Aikawa, E., Alcaraz, M.J., Anderson, J.D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G.K., Ayre, D.C., Bach, J.M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N.N., Baxter, A.A., Bebawy, M., Beckham, C., Bedina Zavec, A., Benmoussa, A., Berardi, A.C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borras, F.E., Bosch, S., Boulanger, C.M., Breakefield, X., Breglio, A.M., Brennan, M.A., Brigstock, D.R., Brisson, A., Broekman, M.L., Bromberg, J.F., Bryl-Gorecka, P., Buch, S., Buck, A.H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzas, E.I., Byrd, J.B., Camussi, G., Carter, D.R., Caruso, S., Chamley, L.W., Chang, Y.T., Chen, C., Chen, S., Cheng, L., Chin, A.R., Clayton, A., Clerici, S.P., Cocks, A., Cocucci, E., Coffey, R.J., Cordeiro da Silva, A., Couch, Y., Coumans, F.A., Coyle, B., Crescitelli, R., Criado, M.F., D’Souza-Schorey, C., Das, S., Datta Chaudhuri, A., De Candia, P., De Santana, E.F., De Wever, O., Del Portillo, H.A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L.C., Dolo, V., Dominguez Rubio, A.P., Dominici, M., Dourado, M.R., Driedonks, T.A., Duarte, F.V., Duncan, H.M., Eichenberger, R.M., Ekstrom, K., El Andaloussi, S., Elie-Caille, C., Erdbrugger, U., Falcon-Perez, J.M., Fatima, F., Fish, J.E., Flores-Bellver, M., Forsonits, A., Frelet-Barrand, A. et al. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J. Extracell Vesicles 7: 1535750.
119 Thery, C., Zitvogel, L., and Amigorena, S. (2002). Exosomes: Composition, biogenesis and function. Nat. Rev. Immunol. 2: 569–579.
120 Tian, Y., Ma, L., Gong, M., Su, G., Zhu, S., Zhang, W., Wang, S., Li, Z., Chen, C., Li, L., Wu, L., and Yan, X. (2018). Protein profiling and sizing of extracellular vesicles from colorectal cancer patients via flow cytometry. ACS Nano 12: 671–680.
121 Tommelein, J., Verset, L., Boterberg, T., Demetter, P., Bracke, M., and De Wever, O. (2015). Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer. Front. Oncol. 5: 63.
122 Topalian, S.L. (2017). Targeting immune checkpoints in cancer therapy. JAMA 318: 1647–1648.
123 Topalian, S.L., Drake, C.G., and Pardoll, D.M. (2015). Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 27: 450–461.
