Bacterial Pathogenesis. Brenda A. Wilson

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      Bacterial

      Pathogenesis

      Fourth Edition

      Bacterial

      Pathogenesis

      A Molecular Approach

      Brenda A. Wilson

      Department of Microbiology

      University of Illinois at Urbana-Champaign

      Urbana-Champaign, Illinois

      Malcolm E. Winkler

      Department of Biology

      Indiana University

      Bloomington, Indiana

      Brian T. Ho

      Institute of Structural and Molecular Biology

      University College London and Birkbeck, University of London

      London, United Kingdom

      Washington, DC

      Copyright © 2019 American Society for Microbiology. All rights reserved. No part of this publication may be reproduced or transmitted in whole or in part or reused in any form or by any means, electronic or mechanical, including photocopying and recording, or by any information storage and retrieval system, without permission in writing from the publisher.

      Disclaimer: To the best of the publisher’s knowledge, this publication provides information concerning the subject matter covered that is accurate as of the date of publication. The publisher is not providing legal, medical, or other professional services. Any reference herein to any specific commercial products, procedures, or services by trade name, trademark, manufacturer, or otherwise does not constitute or imply endorsement, recommendation, or favored status by the American Society for Microbiology (ASM). The views and opinions of the author(s) expressed in this publication do not necessarily state or reflect those of ASM, and they shall not be used to advertise or endorse any product.

      Library of Congress Cataloging-in-Publication Data

      Names: Wilson, Brenda A., author. | Winkler, Malcolm E, author. | Ho, Brian T. (Brian Thomas), author. | Salyers, Abigail A. Bacterial pathogenesis.

      Title: Bacterial pathogenesis : a molecular approach / Brenda A. Wilson, Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, Malcolm E. Winkler, Department of Biology, Indiana University, Bloomington, Indiana, Brian T. Ho, Institute of Structural and Molecular Biology, University College London and Birkbeck, University of London, London, United Kingdom.

      Description: Fourth edition. | Washington, DC : ASM Press, [2019] | Revised and updated edition of the work originally authored by Abigail Salyers and Dixie Whitt.

      Identifiers: LCCN 2019017126 (print) | LCCN 2019018854 (ebook) | ISBN 9781683672883 (eBook) | ISBN 9781555819408 (pbk.)

      Subjects: LCSH: Bacterial diseases—Pathogenesis. | Molecular microbiology.

      Classification: LCC QR201.B34 (ebook) | LCC QR201 .B34 S24 2019 (print) | DDC 579.3/165—dc23

      LC record available at https://lccn.loc.gov/2019017126

      All Rights Reserved

      Printed in Canada

      10 9 8 7 6 5 4 3 2 1

      doi:10.1128/9781555819415

      Address editorial correspondence to

      ASM Press, 1752 N St., N.W.,

      Washington, DC 20036-2904, USA

      Send orders to ASM Press, P.O. Box 605, Herndon, VA 20172, USA

      Phone: 800-546-2416; 703-661-1593

      Fax: 703-661-1501

      E-mail: [email protected]

      Online: http://www.asmscience.org

      Illustrations and illustration concepting: Patrick Lane, ScEYEnce Studios

      Cover and interior design: Debra Naylor, Naylor Design, Inc.

      Cover image: Antibiotic (streptomycin) molecules being expelled out of a bacterium through the TolC efflux-pump. 3d rendering. Image courtesy of Juan Gaertner/Science Photo Library, used with permission. Based on Murakami S, Nakashima R, Yamashita E, Yamaguchi A. 2002. Nature 419:587–593.

      To Abigail A. Salyers and Dixie D. Whitt

      In recognition of their intrepid vision and leadership that forged the foundation of this fascinating exploration of the field of bacterial pathogenesis

      Herein, their legacy lives on.

      Contents

       Preface

       In Memoriam

       About the Authors

       CHAPTER 1 The Power of Bacteria

       Why Are Bacteria So Much in the Public Health Spotlight Nowadays?

       Bacteria, a Formidable Ancient Life Form

       Pressing Current Infectious Disease Issues

       Emerging and Reemerging Infectious Diseases

       Foodborne and Waterborne Infections

       Modern Medicine as a Source of New Diseases

       Postsurgical and Other Wound Infections

       Bioterrorism

       A

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