New Respect for Prevention
Surveillance: An Early Warning System
Making Hospitals Safe for Patients
And Now for Some Good News: You’ve Got a Bacterial Infection!
The Helicobacter pylori Revolution
A Brave New World of Pathogenesis Research
Insights into Pathogen Evolution
Modeling the Host-Pathogen Interaction in Experimental Animals
CHAPTER 2 Skin and Mucosa: The First Lines of Defense against Bacterial Infections
The Best Defense: Avoid, Reduce, and Prevent Exposure!
Barriers: Skin and Mucosal Membranes
The Layers of Cells That Protect the Body
Normal Microbiota of the Skin and Mucosa
Special Defenses of the Gastrointestinal Tract
Special Defenses of the Urogenital Tract
Special Defenses of the Respiratory Tract
Immune Defenses of the Skin and Mucosa
Models for Studying Breaches of Barrier Defenses
CHAPTER 3 The Innate Immune System: Always on Guard
Triggering Innate Immune Defenses
Innate Immune Cells That Defend Blood and Tissue
Monocytes, Macrophages, and Dendritic Cells (DCs)
Granulocytes: Basophils, Mast Cells, and Eosinophils
Transmigration—How Do Phagocytes Know When and Where to Go?
How Phagocytes Recognize and Respond to Bacteria
Oxidative Burst in Phagolysosomes
Autophagy—Another Pathway for the Killing of Intracellular Pathogens
Overview of Complement Pathways and Their Function
Steps in Complement Activation
Controlling Complement Activation
Cytokines and Chemokines—Mediators of Immune Responses
Roles of Cytokines and Chemokines in Directing Innate Immune Responses
