Bacterial Pathogenesis. Brenda A. Wilson

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Inflammation and Collateral Damage

       Septic Shock: The Dark Side of the Innate Defenses

       Other Innate Defenses of the Body—Nutritional Immunity

       Selected Readings

       Questions

       CHAPTER 4 The Adaptive Defenses: Antibodies and Cytotoxic T Cells

       The Specialists: Adapting to a Particular Pathogen Challenge

       B Cells: Producers of Antibodies

       The Humoral (Antibody) Immune Response

       Characteristics of Antibodies and Their Diverse Roles in Preventing Infection

       Serum Antibodies

       Secretory Antibodies: Antibodies That Protect Mucosal Surfaces

       Pathogen and Toxin Neutralization by Antibodies

       Affinity and Avidity

       Cytotoxic T Cells, Also Known as Cytotoxic T Lymphocytes (CTLs)

       Cytotoxic T Lymphocytes: Critical Defense against Intracellular Pathogens

       Antigen Presentation to the Immune System

       Processing of Protein Antigens by Dendritic Cells

       Interaction between APCs and T Cells: The T-Cell-Dependent Response

       Th-(Th1/Th2/Th17)-Cell-Mediated Immunity

       Production of Antibodies by B Cells

       Links between the Innate and Adaptive Defense Systems

       T-Cell-Independent Antibody Responses

       Mucosal Immunity: IgA/sIgA Antibodies

       Development of the Adaptive Immune System from Infancy to Adulthood

       Adaptive Defense Systems in Nonmammals

       The Dark Side of the Adaptive Defenses: Autoimmune Disease

       Selected Readings

       Questions

       Solving Problems in Bacterial Pathogenesis

       CHAPTER 5 The Microbiota of the Human Body: Microbiomes and Beyond

       Importance of the Normal Resident Microbial Populations (Microbiota) of the Human Body

       Characterization of the Body’s Microbiota

       Taking a Microbial Census by Using Microbial rRNA Gene Sequence Analysis

       Characterizing Microbiomes by Using Metagenomic Analysis

       Beyond the Metagenome

       Overview of the Human Microbiota

       Skin Microbiota

       Oropharyngeal Microbiota

       Microbiota of the Small Intestine and Colon

       Microbiota of the Vaginal Tract

       The Other Microbiota: The Forgotten Eukaryotes

       Selected Readings

       Questions

       Solving Problems in Bacterial Pathogenesis

       CHAPTER 6 Microbes and Disease: Establishing a Connection

       History

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